Protein Alignment eve and ARX

DIOPT Version :10

• Sequence 1: NP_523670.2
• Gene: eve / 36039
• FlyBaseID: FBgn0000606
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_620689.1
• Gene: ARX / 170302
• HGNCID: 18060
• Length: 562
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 89/263 - (33%)
• Similarity: 115/263 - (43%)
• Gaps: 45/263 - (17%)

  Fly    48 CLSSPDNSLNGSRGSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPES 112
            |||:      ||...|.......|||||.||..||..||:.|.|.:|.....|.|||.:|:|.|:
Human   312 CLSA------GSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEA 370

  Fly   113 TIKVWFQNRRMK-DKRQRI-AVAWPYAAVYSDPAFAASILQAAANSVGMPYPPYAPA-----AAA 170
            .::|||||||.| .||::. |...|....:..|..|...|....::  .|:||:.||     .||
Human   371 RVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDA--SPFPPHHPALDSAWTAA 433

  Fly   171 AAAAAAAVATNPMMATGMPPMGMPQMPTMQMP-GHSGHAG-----HP---SP-YGQYRYTPYHIP 225
            |||||||..:.|      ||.|...:|....| |.|...|     ||   || :|:...|  ..|
Human   434 AAAAAAAFPSLP------PPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFST--MAP 490

  Fly   226 ARPAPPHPAGPHMHHPHMMGSSATGS-----------SYSAGAAGLLGALPSATCYTGLGVGVPK 279
            ...|....|......|.:.|:.|:|:           ..|:.||..|.|...|...|.|.: :|.
Human   491 LTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNI-LPG 554

  Fly   280 TQT 282
            |.|
Human   555 TST 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eve	NP_523670.2	Homeodomain	71..127	CDD:459649	29/56 (52%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..255
		Homeodomain	329..385	CDD:459649	29/55 (53%)
		OAR	526..544	CDD:461067	5/17 (29%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	530..543		5/12 (42%)