DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eve and Evx2

DIOPT Version :9

Sequence 1:	NP_523670.2	Gene:	eve / 36039	FlyBaseID:	FBgn0000606	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_031993.1	Gene:	Evx2 / 14029	MGIID:	95462	Length:	475	Species:	Mus musculus

Alignment Length:	339	Identity:	124/339 - (36%)
Similarity:	163/339 - (48%)	Gaps:	82/339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GSRGSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIKVWFQNRR 122
            |..||...|| .||||||||||:|:.|||||||:||||||||||||||.|||||:||||||||||
Mouse   180 GGSGSGSGAD-QVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRR 243

  Fly   123 MKDKRQRIAVAWPYAAVYSDPAFAASILQAAANSVGMPYP----------PY----APAAAAAAA 173
            |||||||:|::||:.|   ||:|...::..||.:..:|||          |:    |.||||||:
Mouse   244 MKDKRQRLAMSWPHPA---DPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAAS 305

  Fly   174 AAAAVATNPMMATGMPPMGMPQMPTMQMPGHSGHAGHPSPYGQ------YRYTP-YHIPARPAPP 231
            .|||.|::| .||.:.|     :.|.:...|        ||.:      :|:.. |..||..|..
Mouse   306 GAAAAASSP-FATSIRP-----LDTFRALSH--------PYSRPELLCSFRHPGLYQAPAAAAGL 356

  Fly   232 HPAGPHMHHPHMMGSSATGSSYSAGAAGLLGALP---SATCYTGLGVGVPKTQTPPLDLQSSSSP 293
            :.|.       ...::|..::.:|.:|...||.|   ||.|                   |..|.
Mouse   357 NSAA-------SAAAAAAAAAAAASSAAAAGAPPSGSSAPC-------------------SCLSC 395

  Fly   294 HSSTLSLSPVGSDHAKVFDR-------------SPVAQSAPSVPAPAPLTTTSPLP-APGLLMPS 344
            |||..:.:...:..|.:..|             .....|.....|.||.:.:..|| :..:|..:
Mouse   396 HSSQSAAAAAAAAAAALGSRGGGGSGGGGGGGAGTAGGSDFGCSAAAPRSESGFLPYSAAVLSKT 460

  Fly   345 AKRPASDMSPPPTT 358
            |..|.......|.|
Mouse   461 AVSPPDQRDEAPLT 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eve	NP_523670.2	Homeobox	74..126	CDD:278475	45/51 (88%)
Evx2	NP_031993.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..189		3/8 (38%)
		Homeobox	195..248	CDD:365835	46/52 (88%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6237
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002730
OrthoInspector	1	1.000	-	-		otm42727
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46294
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2896
SonicParanoid	1	1.000	-	-		X2525
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.180