DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12134 and SPCC63.06

DIOPT Version :9

Sequence 1:	NP_001369072.1	Gene:	CG12134 / 36038	FlyBaseID:	FBgn0033471	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_587980.1	Gene:	SPCC63.06 / 2538796	PomBaseID:	SPCC63.06	Length:	331	Species:	Schizosaccharomyces pombe

Alignment Length:	366	Identity:	89/366 - (24%)
Similarity:	162/366 - (44%)	Gaps:	59/366 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGDEDTCSAQDLAAEFQLKYKPQDEVSVSLQREYVLSLAADQGFSRMAAGLSNSAVHIYNLDSGA 89
            :.:||.|...|:.   |||    |.|.||      .|..:...|.:      .:.:.|:.:....
pombe    10 VSNEDECFIYDIE---QLK----DNVVVS------YSTGSWSCFDK------GTLLEIFKVPKAH 55

  Fly    90 GKLENFSYLPPTDSPQSVSICGVRFLDEGPHNILVGTTDGYVRLYDLRLRGEQARFKYTQHPNVP 154
               .|.:.:...|....|..||               ::|.:.|:|:|.:.:.|...:||. :.|
pombe    56 ---TNITGIISCDQLNGVITCG---------------SEGEIHLWDIRSQAKSAVRSWTQQ-STP 101

  Fly   155 PVPKSLSCFDRNANGRIICCGTEQFHSNAFLVFFDVRERQQM-GVYFESHEDDITSLRFHAQNPD 218
                 .:|...|...: ...|:|...|.|.:..:|||..|:: ..:.::|.||||.|:||.::.:
pombe   102 -----FTCIALNKKNQ-FATGSELTRSLASVQLWDVRSEQKLIRQWNDAHNDDITHLQFHPKDNE 160

  Fly   219 LLATGSVDGLVNVFD-VKEPD----EDEALLNTFNTESSVARLAWHRNVYDKDIISCVTTTGDFK 278
            ||.||||||||::.| .||.|    |::.||:..|..:|: .||   ....|..:..::....:.
pombe   161 LLLTGSVDGLVSLLDTTKEEDSTDPEEDPLLHVINHGASI-HLA---KFVSKKRVMVLSHMESYA 221

  Fly   279 SYECEEGDEVASFERPDVTAA--IRRKKAANFNLINAHNQEDGGVFLLAGTNFNKGEILRSVSVT 341
            .|:.:...:..::...::.:.  :|.:.:.:: :||..:..|.....||..:|:..|....:..|
pombe   222 MYKLKRDKDEKTWSSNELFSIDDLRAELSCSY-VINEVSTSDKQFCALAFGDFSNHETKFVLVDT 285

  Fly   342 SKNSL--QPLANFQGNKQIVRDSLFDSKRSLLFTGGESGIV 380
            |...|  :|....:.:::|.|...||.|..:.::|||.|::
pombe   286 STGELKKEPTKLERASEEICRAISFDVKNDVYYSGGEDGLL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12134	NP_001369072.1	WD40	56..384	CDD:421866	78/335 (23%)
		WD40 repeat	59..101	CDD:293791	4/41 (10%)
		WD40 repeat	108..146	CDD:293791	7/37 (19%)
		WD40 repeat	153..201	CDD:293791	11/48 (23%)
		WD40 repeat	207..248	CDD:293791	22/45 (49%)
		WD40 repeat	300..353	CDD:293791	12/54 (22%)
		WD40 repeat	359..390	CDD:293791	8/22 (36%)
SPCC63.06	NP_587980.1	WD40	5..>331	CDD:225201	89/366 (24%)
		WD40	47..>180	CDD:295369	44/157 (28%)
		WD40 repeat	59..97	CDD:293791	9/52 (17%)
		WD40 repeat	102..142	CDD:293791	10/40 (25%)
		WD40 repeat	150..185	CDD:293791	18/34 (53%)
		WD40 repeat	200..241	CDD:293791	4/44 (9%)
		WD40 repeat	255..298	CDD:293791	11/42 (26%)
		Salt_tol_Pase	<261..330	CDD:302929	18/66 (27%)
		WD40 repeat	305..329	CDD:293791	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1188
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43791
Inparanoid	1	1.050	76	1.000	Inparanoid score	I1889
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005225
OrthoInspector	1	1.000	-	-		oto101270
orthoMCL	1	0.900	-	-		OOG6_103591
Panther	1	1.100	-	-	LDO	PTHR22889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4240
TreeFam	1	0.960	-	-
	11	10.820