Protein Alignment CG12134 and WDR89

DIOPT Version :10

• Sequence 1: NP_610542.1
• Gene: CG12134 / 36038
• FlyBaseID: FBgn0033471
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: XP_011534685.1
• Gene: WDR89 / 112840
• HGNCID: 20489
• Length: 425
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 124/417 - (29%)
• Similarity: 191/417 - (45%)
• Gaps: 62/417 - (14%)

  Fly    24 DIGDEDTCSAQDLAAEFQLKYKPQDE-------VSVSL---QREYVL----SLAADQGFSRMAAG 74
            :.|...|||...|..:..:..:..:|       |..||   :..|:|    |.....|...:.|.
Human    19 EAGASLTCSRVLLPLDAAVDMEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAV 83

  Fly    75 L-SNSAVHIYNLDSGAGKLENFSYLPPTDSPQSVSICGVRFLDEGPHNILVGTTDGYVRLYDLRL 138
            | ||.::.||:.:. ...|..||..|..       :.||||.: ...::....|||.|:.:|.|:
Human    84 LCSNGSIRIYDKER-LNVLREFSGYPGL-------LNGVRFAN-SCDSVYSACTDGTVKCWDARV 139

  Fly   139 RGEQARFKYTQHPNVPPVPKSLSCFDRNANGRIICCGTEQFHSNAFLVFFDVRERQQ-------- 195
            ..|:....:..:|:     .....||.|.|..|||.|||:...:|.|||:|.|...|
Human   140 AREKPVQLFKGYPS-----NIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDS 199

  Fly   196 MGVYFESHEDDITSLRFHAQNPDLLATGSVDGLVNVFDVKEPDEDEALLNTFNTESSVARLAWHR 260
            :|.|.|:|.||:|.:|||..||:::.:||.||||||||:...:|::||:.|.|:.|||:.:.|..
Human   200 LGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSG 264

  Fly   261 NVYDKDIISCVTTTGDFKSYECE--EGDE-VASFERPDVTAAIRRKKAANFNLINA-HNQEDGGV 321
            ..|.:  |.|:|....|..::..  :.|| |......||...:..|:.|...||.. ::::...:
Human   265 KGYKQ--IYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTL 327

  Fly   322 FLLAGTNFNKGEI-LRSVS---VTSKNSLQPLANFQGNKQIVRDSLFDSKRSLLFTGGESGIVTV 382
            .::.||  |||.| |.:.|   :|...|||     .|:...||...::.:...|.||||...:.:
Human   328 HVIGGT--NKGRIHLMNCSMSGLTHVTSLQ-----GGHAATVRSFCWNVQDDSLLTGGEDAQLLL 385

  Fly   383 WAQDASGTAFSSEKLKARKEKKSRKQA 409
            |...|....|:        :|:|.|.|
Human   386 WKPGAIEKTFT--------KKESMKIA 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12134	NP_610542.1	WD40	56..384	CDD:475233	108/348 (31%)
		WD40 repeat	59..101	CDD:293791	13/46 (28%)
		WD40 repeat	108..146	CDD:293791	11/37 (30%)
		WD40 repeat	153..201	CDD:293791	19/55 (35%)
		WD40 repeat	207..248	CDD:293791	20/40 (50%)
		WD40 repeat	300..353	CDD:293791	16/57 (28%)
		WD40 repeat	359..390	CDD:293791	9/30 (30%)
WDR89	XP_011534685.1	WD40	79..387	CDD:475233	104/330 (32%)
		WD40 repeat	112..150	CDD:293791	11/38 (29%)
		WD40 repeat	156..198	CDD:293791	17/41 (41%)
		WD40 repeat	212..250	CDD:293791	19/37 (51%)
		WD40 repeat	257..297	CDD:293791	10/41 (24%)
		WD40 repeat	305..355	CDD:293791	14/51 (27%)
		WD40 repeat	362..386	CDD:293791	7/23 (30%)