DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12134 and WDR89

DIOPT Version :9

Sequence 1:	NP_001369072.1	Gene:	CG12134 / 36038	FlyBaseID:	FBgn0033471	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_011534685.1	Gene:	WDR89 / 112840	HGNCID:	20489	Length:	425	Species:	Homo sapiens

Alignment Length:	417	Identity:	124/417 - (29%)
Similarity:	191/417 - (45%)	Gaps:	62/417 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DIGDEDTCSAQDLAAEFQLKYKPQDE-------VSVSL---QREYVL----SLAADQGFSRMAAG 74
            :.|...|||...|..:..:..:..:|       |..||   :..|:|    |.....|...:.|.
Human    19 EAGASLTCSRVLLPLDAAVDMEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVAV 83

  Fly    75 L-SNSAVHIYNLDSGAGKLENFSYLPPTDSPQSVSICGVRFLDEGPHNILVGTTDGYVRLYDLRL 138
            | ||.::.||:.:. ...|..||..|..       :.||||.: ...::....|||.|:.:|.|:
Human    84 LCSNGSIRIYDKER-LNVLREFSGYPGL-------LNGVRFAN-SCDSVYSACTDGTVKCWDARV 139

  Fly   139 RGEQARFKYTQHPNVPPVPKSLSCFDRNANGRIICCGTEQFHSNAFLVFFDVRERQQ-------- 195
            ..|:....:..:|:     .....||.|.|..|||.|||:...:|.|||:|.|...|
Human   140 AREKPVQLFKGYPS-----NIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKDS 199

  Fly   196 MGVYFESHEDDITSLRFHAQNPDLLATGSVDGLVNVFDVKEPDEDEALLNTFNTESSVARLAWHR 260
            :|.|.|:|.||:|.:|||..||:::.:||.||||||||:...:|::||:.|.|:.|||:.:.|..
Human   200 LGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISSVSCIGWSG 264

  Fly   261 NVYDKDIISCVTTTGDFKSYECE--EGDE-VASFERPDVTAAIRRKKAANFNLINA-HNQEDGGV 321
            ..|.:  |.|:|....|..::..  :.|| |......||...:..|:.|...||.. ::::...:
Human   265 KGYKQ--IYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDYLIGGLYHEKTDTL 327

  Fly   322 FLLAGTNFNKGEI-LRSVS---VTSKNSLQPLANFQGNKQIVRDSLFDSKRSLLFTGGESGIVTV 382
            .::.||  |||.| |.:.|   :|...|||     .|:...||...::.:...|.||||...:.:
Human   328 HVIGGT--NKGRIHLMNCSMSGLTHVTSLQ-----GGHAATVRSFCWNVQDDSLLTGGEDAQLLL 385

  Fly   383 WAQDASGTAFSSEKLKARKEKKSRKQA 409
            |...|....|:        :|:|.|.|
Human   386 WKPGAIEKTFT--------KKESMKIA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12134	NP_001369072.1	WD40	56..384	CDD:421866	108/348 (31%)
		WD40 repeat	59..101	CDD:293791	13/46 (28%)
		WD40 repeat	108..146	CDD:293791	11/37 (30%)
		WD40 repeat	153..201	CDD:293791	19/55 (35%)
		WD40 repeat	207..248	CDD:293791	20/40 (50%)
		WD40 repeat	300..353	CDD:293791	16/57 (28%)
		WD40 repeat	359..390	CDD:293791	9/30 (30%)
WDR89	XP_011534685.1	WD40	69..>387	CDD:225201	106/340 (31%)
		WD40	79..387	CDD:295369	104/330 (32%)
		WD40 repeat	112..150	CDD:293791	11/38 (29%)
		WD40 repeat	156..198	CDD:293791	17/41 (41%)
		WD40 repeat	212..250	CDD:293791	19/37 (51%)
		WD40 repeat	257..297	CDD:293791	10/41 (24%)
		WD40 repeat	305..355	CDD:293791	14/51 (27%)
		WD40 repeat	362..386	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43791
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4672
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54464
OrthoDB	1	1.010	-	-		D1546666at2759
OrthoFinder	1	1.000	-	-		FOG0005225
OrthoInspector	1	1.000	-	-		oto90016
orthoMCL	1	0.900	-	-		OOG6_103591
Panther	1	1.100	-	-	LDO	PTHR22889
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910