DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3j and Eif3j2

DIOPT Version :9

Sequence 1:	NP_001286260.1	Gene:	eIF3j / 36037	FlyBaseID:	FBgn0027619	Length:	236	Species:	Drosophila melanogaster
Sequence 2:	NP_001242984.1	Gene:	Eif3j2 / 100042807	MGIID:	3704486	Length:	263	Species:	Mus musculus

Alignment Length:	249	Identity:	100/249 - (40%)
Similarity:	149/249 - (59%)	Gaps:	15/249 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADDWESAADS-EVVIRPTA---AASVNKWEGEDEDEDIKDSWEDEEEKKDEEKPTKTEA--PAKP 60
            :|.|::...| |..:|..|   .|..::|||||||||:||:|:|::::..||...|.|.  ..|.
Mouse    16 SDSWDADTFSMEDPVRKVAGGGTAGGDRWEGEDEDEDVKDNWDDDDDENKEEAEVKPEVKISEKK 80

  Fly    61 KPNKALKAKLEQQALLEEEAEAKRLAN------LSPAEKLAEKLRLQKIQEASDLKHAQEAFGVT 119
            |..:.:|.|..||...:||.: |||..      |:|.|:||:||||:|:||.|||:.|:|.|||.
Mouse    81 KIAEKIKEKERQQKKRQEEIK-KRLEEPEESKVLTPEEQLADKLRLKKLQEESDLELAKETFGVN 144

  Fly   120 STCGGLDAFNPETKEEFKEFGATLSWKVGQFRESEHFPQFVEDLVRSLCVNLSAADIKKVKMNVE 184
            :|..|:||.||.::::|.|||..|..|:.|:.:|.::..|:|.|||.:|::|...|:||:..::.
Mouse   145 NTVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEALVRDVCISLEIDDLKKITNSLT 209

  Fly   185 ILHSEKLKLEKANAKKPAGKG--KGKVTLRTENDDIDGYQKYGNDFTEDYDDFM 236
            :|.|||.|.||.:..|...||  .|.....|..||:..|..|...:.:||:|||
Mouse   210 VLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYEGGYVQDYEDFM 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3j	NP_001286260.1	eIF3_subunit	3..236	CDD:285763	98/246 (40%)
Eif3j2	NP_001242984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115		36/99 (36%)
		Sufficient for interaction with EIF3B. /evidence=ECO:0000255\|HAMAP-Rule:MF_03009	6..74		23/57 (40%)
		eIF3_subunit	17..263	CDD:285763	98/246 (40%)
		Promotes stable association with the 40S ribosome. /evidence=ECO:0000255\|HAMAP-Rule:MF_03009	248..263		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849122
Domainoid	1	1.000	172	1.000	Domainoid score	I3710
eggNOG	1	0.900	-	-		E1_KOG4813
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37845
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4071
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55542
OrthoDB	1	1.010	-	-		D1565510at2759
OrthoFinder	1	1.000	-	-		FOG0004066
OrthoInspector	1	1.000	-	-		otm43556
orthoMCL	1	0.900	-	-		OOG6_103515
Panther	1	1.100	-	-	LDO	PTHR21681
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4553
SonicParanoid	1	1.000	-	-		X5085
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800