DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12133 and F11

DIOPT Version :10

Sequence 1:NP_610540.2 Gene:CG12133 / 36036 FlyBaseID:FBgn0033469 Length:340 Species:Drosophila melanogaster
Sequence 2:XP_005262878.1 Gene:F11 / 2160 HGNCID:3529 Length:626 Species:Homo sapiens


Alignment Length:334 Identity:93/334 - (27%)
Similarity:139/334 - (41%) Gaps:85/334 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 KILHPRNMTNDQKSQYRNKLCNINPFAHELVHMVFTCCPMVAGDKLPDSRVCGQSPPSSYIVGGM 66
            ||||.|...    |.|..:||.:                        |:....:..|.  ||||.
Human   359 KILHGRGGI----SGYTLRLCKM------------------------DNECTTKIKPR--IVGGT 393

  Fly    67 EAQSNQFPWTVLLGYEAYTAKQRPSPMCAGSLIASRYVLTAAHCLNVNDFY------VARVR--- 122
            .:...::||.|.|    :|.......:|.||:|.::::||||||     ||      :.||.   
Human   394 ASVRGEWPWQVTL----HTTSPTQRHLCGGSIIGNQWILTAAHC-----FYGVESPKILRVYSGI 449

  Fly   123 LGEHDTENDPDYTWLPNGAKIWAPAHVDIDVDLRVPHEQYYTRNGRHYNDIALLRLKSRVKYTLQ 187
            |.:.:.:.|..:                ..|...:.|:||......:  |||||:|::.|.||..
Human   450 LNQSEIKEDTSF----------------FGVQEIIIHDQYKMAESGY--DIALLKLETTVNYTDS 496

  Fly   188 IRPICIWPGIELSTSSFKNFPFQ---IAGWGDSGLQQK-STVLRQGTISGMSPDECLNRYPTLLV 248
            .||||      |.:...:|..:.   :.|||...|:.| ...|::..|..::.:||..||....:
Human   497 QRPIC------LPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKI 555

  Fly   249 DKDIQICAMGW--DGTDTGLGDSGSPLMASVGRGADQFYYLAGITSYGGGPSSYGYGPAVYTKTS 311
            ...: ||| |:  .|.|...||||.||...    .::.::|.||||:|.| .:....|.|||...
Human   556 THKM-ICA-GYREGGKDACKGDSGGPLSCK----HNEVWHLVGITSWGEG-CAQRERPGVYTNVV 613

  Fly   312 SYYEWIKKK 320
            .|.:||.:|
Human   614 EYVDWILEK 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12133NP_610540.2 Tryp_SPc 62..317 CDD:214473 79/269 (29%)
F11XP_005262878.1 APPLE 20..103 CDD:128519
APPLE 110..193 CDD:128519
APPLE 200..283 CDD:128519
APPLE 291..375 CDD:128519 7/19 (37%)
Tryp_SPc 389..619 CDD:238113 79/269 (29%)
Blue background indicates that the domain is not in the aligned region.

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