DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1418 and Rabac1

DIOPT Version :9

Sequence 1:	NP_610539.1	Gene:	CG1418 / 36035	FlyBaseID:	FBgn0033468	Length:	193	Species:	Drosophila melanogaster
Sequence 2:	NP_113962.1	Gene:	Rabac1 / 83583	RGDID:	621002	Length:	185	Species:	Rattus norvegicus

Alignment Length:	159	Identity:	56/159 - (35%)
Similarity:	92/159 - (57%)	Gaps:	4/159 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LPSLSNLPSPLQIFQMVRNSLRPWVVFFNINNFKTAISMQRLNSRVIRNLSYFQANYVFIFFVLM 93
            ||.|....:..:..:..|.::|||..|.:...|....::..|..|::||:.|:|:||||:|..|:
  Rat    22 LPKLIPSGAGREWLERRRATIRPWGTFVDQQRFSRPRNVGELCQRLVRNVEYYQSNYVFVFLGLI 86

  Fly    94 IYCLITAPCILLVILASAFG-CH--KLRVRNSNITIVGQQLTPSQQIIALNLATAPVLFLVGAGA 155
            :||::|:| :|||.||..|| |:  .||...|.:.:.|::::|:.|.......:.|..:|.|||:
  Rat    87 LYCVVTSP-MLLVALAVFFGACYILYLRTLQSKLVLFGREVSPAHQYALAGGVSFPFFWLAGAGS 150

  Fly   156 VLFWTLGASCFVIAMHAIFYNIDAIVTEE 184
            .:||.|||:..:|..||.|:.|:....||
  Rat   151 AVFWVLGATLVLIGSHAAFHQIEPADGEE 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1418	NP_610539.1	PRA1	48..178	CDD:281235	49/132 (37%)
Rabac1	NP_113962.1	Required for interaction with prenylated RAB3A and VAMP2	30..54		5/23 (22%)
		PRA1	38..170	CDD:397359	49/132 (37%)
		Required for interaction with GDI1. /evidence=ECO:0000269\|PubMed:10751420	165..185		6/15 (40%)
		Homodimerization. /evidence=ECO:0000250	175..185		2/5 (40%)
		Required for interaction with prenylated RAB3A and VAMP2	175..185		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353232
Domainoid	1	1.000	99	1.000	Domainoid score	I6937
eggNOG	1	0.900	-	-		E1_KOG3142
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38182
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4855
OMA	1	1.010	-	-		QHG52029
OrthoDB	1	1.010	-	-		D1344798at2759
OrthoFinder	1	1.000	-	-		FOG0006570
OrthoInspector	1	1.000	-	-		oto97596
orthoMCL	1	0.900	-	-		OOG6_102188
Panther	1	1.100	-	-	LDO	PTHR19317
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6316
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770