DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pal1 and NHLRC3

DIOPT Version :9

Sequence 1:	NP_001137630.2	Gene:	Pal1 / 36033	FlyBaseID:	FBgn0283510	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001012772.1	Gene:	NHLRC3 / 387921	HGNCID:	33751	Length:	347	Species:	Homo sapiens

Alignment Length:	446	Identity:	92/446 - (20%)
Similarity:	152/446 - (34%)	Gaps:	154/446 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLGSKSLAICCLLLHLLLCIRPAV-----SQTQSPQRYLHNVDSNSNNNERLHQILKGSGAGSGA 68
            |:......:..|:||...|..|.:     :.:...::.|:.:|
Human     7 CVAGAGFFLAFLVLHSRFCGSPVLRNFTFAVSWRTEKILYRLD---------------------- 49

  Fly    69 TQLNWPQPPKQ-TVPNVKTELAKLNN-TYVYQNAWPANNVKLGAVTAVSFDKAGNVVIFHRVN-- 129
              :.||:.|:. |.......:..||. .|:.|..                |....:::|....
Human    50 --VGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRG----------------DNIPKILVFTEDGYF 96

  Fly   130 -RVWGQTTFDNRNQYQEKYRGPIRESTILALEPATGKVQYDWGKNFFYMPHGLTVDP---EDNVW 190
             |.|..|. |.                                      |||:....   |.:||
Human    97 LRAWNYTV-DT--------------------------------------PHGIFAASTLYEQSVW 122

  Fly   191 LTDVAM----HQVFKFPPRGGDGKPALTLGDAFQ----PG------SGRKFCKPTSVAVLDNGDF 241
            :|||..    |.|.|:.          :.||..|    ||      :..:|..|..:.|.|.||.
Human   123 ITDVGSGFFGHTVKKYS----------SFGDLVQVLGTPGKKGTSLNPLQFDNPAELYVEDTGDI 177

  Fly   242 FV--ADGYCNARILKYSRKGELILFW--GQNTFSGISYDVAPQNFFAIPHALTLVPELQLLCAAD 302
            ::  .||..|.|::|.|:  :.::.|  |:|       ...|.. |.|||::|| .....:..||
Human   178 YIVDGDGGLNNRLIKLSQ--DFMILWLHGEN-------GTGPAK-FNIPHSVTL-DSAGRVWVAD 231

  Fly   303 RENGRVQCFLSSNGTFHSQYHNQLIGDRLFSMAYTPAAGGQLVIVNGPTAELGIHPEHYNEVHGF 367
            |.|.|:|.|....|.:...::|....:...|:.:||  .|:.:||    |:|.:..
Human   232 RGNKRIQVFDKDTGEWLGAWNNCFTEEGPSSVRFTP--DGKYLIV----AQLNLSR--------- 281

  Fly   368 VLSMRSKQLVSKFGP----NNLQFQN---PHDVAVTADGNEIYVAELNPMRIHKFV 416
             ||:.:...|...|.    :.:|..:   ||.:.|......:||||:...::.|:|
Human   282 -LSVVAAPPVGSIGECSVISTIQLADQVLPHLLEVDRKTGAVYVAEIGAKQVQKYV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pal1	NP_001137630.2	NHL_PAL_like	97..416	CDD:271328	76/349 (22%)
		NHL repeat	111..172	CDD:271328	6/63 (10%)
		NHL repeat	178..220	CDD:271328	14/48 (29%)
		NHL repeat	230..267	CDD:271328	12/40 (30%)
		NHL repeat	283..321	CDD:271328	14/37 (38%)
		NHL repeat	330..382	CDD:271328	11/51 (22%)
		NHL repeat	388..415	CDD:271328	7/29 (24%)
NHLRC3	NP_001012772.1	NHL 1	47..93		11/85 (13%)
		NHL	66..336	CDD:302697	79/361 (22%)
		NHL repeat	107..153	CDD:271320	16/55 (29%)
		NHL 2	150..196		14/47 (30%)
		NHL repeat	166..205	CDD:271320	12/40 (30%)
		NHL 3	200..243		17/51 (33%)
		NHL repeat	213..250	CDD:271320	14/37 (38%)
		NHL repeat	258..295	CDD:271320	11/52 (21%)
		NHL 4	294..338		11/43 (26%)
		NHL repeat	308..335	CDD:271320	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7690
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860