DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pal1 and Nhlrc3

DIOPT Version :9

Sequence 1:	NP_001137630.2	Gene:	Pal1 / 36033	FlyBaseID:	FBgn0283510	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_766089.1	Gene:	Nhlrc3 / 212114	MGIID:	2444520	Length:	347	Species:	Mus musculus

Alignment Length:	437	Identity:	97/437 - (22%)
Similarity:	154/437 - (35%)	Gaps:	136/437 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLGSKSLAICCLLLHLLLCIRPAVSQTQSPQRYLHNVDSNSNNNERLHQILKGSGAGSGATQLNW 73
            ||...:..:.||:||...| ...||:|.|                 .|              ::|
Mouse     7 CLAGAAFFLSCLVLHSRFC-GSLVSRTFS-----------------FH--------------VSW 39

  Fly    74 PQPPKQTVPNVKTELAKLNNTYVYQNAWPANNVKL-GAVTAVSFDKA-GNVVIFHRVNRVWGQTT 136
                :...|..:.:|           .||.|:... ||...|:.|.. |.|.:..|.:.:.....
Mouse    40 ----RMEDPLFRLDL-----------GWPKNSEYFTGATFCVAVDSLNGLVYVAQRGDNIPKVLV 89

  Fly   137 FDNRNQYQEKYRGPIRESTILALEPATGKVQYDWGKNFFYMPHGLTVDP---EDNVWLTDVAMHQ 198
            |.....:...:...:.                        .|||:.|..   |.:||:|||..
Mouse    90 FSEDGYFLRAWNYTVD------------------------TPHGMFVSGTPFEQSVWITDVGS-- 128

  Fly   199 VFKFPPRGGDGKPALTLGDAFQ----PG------SGRKFCKPTSVAVLDNGDFFV--ADGYCNAR 251
                .|.|...|...:|||..|    ||      :..:|..|..:.|.|.|:.::  .||..|.|
Mouse   129 ----GPYGHTVKKYNSLGDLVQVLGTPGKKGTGLNPLQFDNPAELYVDDTGEMYIVDGDGGLNNR 189

  Fly   252 ILKYSRKGELILFW--GQNTFSGISYDVAPQNFFAIPHALTLVPELQLLCAADRENGRVQCFLSS 314
            ::|.|:  :.::.|  |:|       ...|.. |.|||::|| ..:..:..|||.|.|:|.|...
Mouse   190 LVKLSQ--DFMILWLRGEN-------GTGPAK-FNIPHSVTL-DAVGRVWVADRGNKRLQVFDKD 243

  Fly   315 NGTFHSQYHNQLIGDRLFSMAYTPAAGGQLVIVNGPTAELGIHPEHYNEVHGFVLSMRSKQLVSK 379
            .|.:...:.|....:...::.:||  .|:.:||    |:|.             ||..|..|...
Mouse   244 TGEWLGAWDNCFTEEGPSAVRFTP--DGKYLIV----AQLN-------------LSRLSVLLAPP 289

  Fly   380 FGP-------NNLQFQN---PHDVAVTADGNEIYVAELNPMRIHKFV 416
            .|.       :.:|..:   ||.:.|......:||||:...:|.|::
Mouse   290 SGSIGDCSVVSTIQLADQVLPHLLEVDRKTGAVYVAEIGAKQIQKYI 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pal1	NP_001137630.2	NHL_PAL_like	97..416	CDD:271328	82/347 (24%)
		NHL repeat	111..172	CDD:271328	6/61 (10%)
		NHL repeat	178..220	CDD:271328	16/44 (36%)
		NHL repeat	230..267	CDD:271328	11/40 (28%)
		NHL repeat	283..321	CDD:271328	14/37 (38%)
		NHL repeat	330..382	CDD:271328	11/51 (22%)
		NHL repeat	388..415	CDD:271328	8/29 (28%)
Nhlrc3	NP_766089.1	NHL 1	47..93		12/56 (21%)
		NHL	66..336	CDD:302697	77/329 (23%)
		YncE	<66..308	CDD:225926	68/301 (23%)
		NHL repeat	107..153	CDD:271320	18/51 (35%)
		NHL 2	150..196		13/47 (28%)
		NHL repeat	166..205	CDD:271320	11/40 (28%)
		NHL 3	200..243		17/51 (33%)
		NHL repeat	213..250	CDD:271320	14/37 (38%)
		NHL repeat	258..299	CDD:271320	12/59 (20%)
		NHL 4	294..338		10/43 (23%)
		NHL repeat	308..335	CDD:271320	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7690
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860