DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pal1 and pam

DIOPT Version :9

Sequence 1:	NP_001137630.2	Gene:	Pal1 / 36033	FlyBaseID:	FBgn0283510	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001184164.1	Gene:	pam / 100170159	XenbaseID:	XB-GENE-950935	Length:	985	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	192/565 - (33%)
Similarity:	285/565 - (50%)	Gaps:	98/565 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VSQTQSP----QRYLHNVDSNSNN---NERLHQILKGSGAGSGATQLNWPQPPKQTVPNVK---- 85
            |.|.:.|    .|.:...|...|.   .:|:|:..|....         .:||..|:|.|:
Frog   430 VVQKKDPGWYYDRQVLGHDKQPNTVLVRDRIHKFHKLEST---------LRPPGNTLPQVQQGRP 485

  Fly    86 -----TELAKLNNTYVYQNA-WPANNVKLGAVTAVSFDKAGNVVIFHRVNRVWGQTTFDNRNQYQ 144
                 .|...|.:.::.::. ||..|:|:|.|:.::.|...|:|||||.:.||.:.:||....||
Frog   486 AGADTREKQHLGDVHLEEDTDWPGVNLKVGQVSGLALDPKNNLVIFHRGDHVWDENSFDRNFVYQ 550

  Fly   145 EKYRGPIRESTILALEPATGKVQYDWGKNFFYMPHGLTVDPEDNVWLTDVAMHQVFKFPPRGGDG 209
            ::..|||:|||||.::|.|.||....|||.|::|||||:|.:.|.|:||||:|||||.   |.:.
Frog   551 QRGIGPIQESTILVVDPNTSKVLKSAGKNLFFLPHGLTIDRDGNYWVTDVALHQVFKL---GAEK 612

  Fly   210 K-PALTLGDAFQPGSGRK-FCKPTSVAVLD--NGDFFVADGYCNARILKYSRKGELILFWGQNTF 270
            : |.|.||.||||||.|| ||:||.||| |  .|:|||:|||||:||:::|..|..|:.||..|.
Frog   613 ETPLLVLGKAFQPGSDRKHFCQPTDVAV-DPITGNFFVSDGYCNSRIMQFSPNGMFIMQWGDETS 676

  Fly   271 SGISYDVAPQ-NFFAIPHALTLVPELQLLCAADRENGRVQCFLSSNGTFHSQYHNQLIGDRLFSM 334
            |.|     |: ..|.|||:||:||:...||.|||||||:|||.:..|.|..|..::..|..:|::
Frog   677 STI-----PKPGQFRIPHSLTMVPDHGQLCVADRENGRIQCFHAETGKFVKQIKHREFGREVFAV 736

  Fly   335 AYTPAAGGQLVIVNGPTAELGIHPEHYNE---VHGFVLSMRSKQLVSKFGPNNLQFQNPHDVAVT 396
            :|.|  ||.|..|||        ..:|.:   |.||:|:..:.:::..|.|....|:.|||:|..
Frog   737 SYAP--GGVLYAVNG--------KPYYGDSAPVQGFMLNFSNGEILDTFIPARKNFEMPHDIAAA 791

  Fly   397 ADGNEIYVAELNPMRIHKF-----VHRSLAKP-----------------MSLSASKDSRDSAISQ 439
            .||. :||.:.:...:.||     .|||:.|.                 .|...:.::.....:|
Frog   792 DDGT-VYVGDAHANAVWKFSPSRAEHRSVKKAGIEVEEIKEIEIFETHMRSRPKTNETTTEKQAQ 855

  Fly   440 AVGGDQVPAVAVHHPSGKA-ILVASLMLLFAGSTFALALIFARRRKRGCLPFGARGRRHAWEKSD 503
            .....:..:|.....:|.: :|:.:|:::......|:| ||.|.||  ...:|. ...|..|.|.
Frog   856 EKQTQEKQSVVQESSAGVSFVLIITLLIIPIVVLIAIA-IFIRWRK--VRMYGG-DIDHKSESSS 916

  Fly   504 GFKLGGLLDR-----------------DRNGFEKLDQQASDEEQE 531
            |..||.|..:                 .|.||::|..:.||:|::
Frog   917 GGILGKLRGKGSGGLNLGTFFATHKGYSRKGFDRLSTEGSDQEKD 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pal1	NP_001137630.2	NHL_PAL_like	97..416	CDD:271328	144/332 (43%)
		NHL repeat	111..172	CDD:271328	26/60 (43%)
		NHL repeat	178..220	CDD:271328	23/42 (55%)
		NHL repeat	230..267	CDD:271328	21/38 (55%)
		NHL repeat	283..321	CDD:271328	22/37 (59%)
		NHL repeat	330..382	CDD:271328	15/54 (28%)
		NHL repeat	388..415	CDD:271328	8/26 (31%)
pam	NP_001184164.1	Cu2_monooxygen	60..169	CDD:366454
		Cu2_monoox_C	197..343	CDD:367618
		NHL_PAL_like	503..810	CDD:271328	143/326 (44%)
		NHL repeat	517..578	CDD:271328	26/60 (43%)
		NHL repeat	584..624	CDD:271328	23/42 (55%)
		NHL repeat	635..673	CDD:271328	21/38 (55%)
		NHL repeat	685..723	CDD:271328	22/37 (59%)
		NHL repeat	731..777	CDD:271328	15/55 (27%)
		NHL repeat	783..809	CDD:271328	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I2968
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224754at33208
OrthoFinder	1	1.000	-	-		FOG0002923
OrthoInspector	1	1.000	-	-		oto105063
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5001
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060