Protein Alignment Mef2 and RLM1

DIOPT Version :9

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_015236.1
• Gene: RLM1 / 856016
• SGDID: S000006010
• Length: 676
• Species: Saccharomyces cerevisiae
• Alignment Length: 672
• Identity: 167/672 - (24%)
• Similarity: 261/672 - (38%)
• Gaps: 206/672 - (30%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            |||:||:|.||:|:|||.|||.|||.|:.|||:||||||..:||:||..|:|..|:::|.|.:.:
Yeast     1 MGRRKIEIQRISDDRNRAVTFIKRKAGLFKKAHELSVLCQVDIAVIILGSNNTFYEFSSVDTNDL 65

  Fly    66 LLKY-------------TEYNEPHES--------LTNKNIIEKENKNGVMSPDSPEAETDYTLTP 109
            :..|             ::|.:.|:|        |...::..|.:|:.|...:..|.:.|
Yeast    66 IYHYQNDKNLLHEVKDPSDYGDFHKSASVNINQDLLRSSMSNKPSKSNVKGMNQSENDDD----- 125

  Fly   110 RTEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTL--PVSV--PVPGS-----YGDNLLQ 165
               ...::.|::..|..:.:.|......:.:.:|::...|  |.::  .:.||     :.:|.|
Yeast   126 ---ENNDEDDDDHGNFERNSNMHSNKKASDKNIPSAHMKLLSPTALISKMDGSEQNKRHPENAL- 186

  Fly   166 ASPQMSH--------TNISPRPSSSETDSV---YPSGSMLEMSNGYPHSHSPLVGSPSPGPSPGI 219
              |.:.|        ..||..|...:..::   |.| ||..::.  |.|.|   .|||....|
Yeast   187 --PPLQHLKRLKPDPLQISRTPQQQQQQNISRPYHS-SMYNLNQ--PSSSS---SSPSTMDFP-- 241

  Fly   220 AHHLSIKQQSPGSQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPI 284
              .|...|.|  |.|||        ||.|:..|...|.|         .:..|..||
Yeast   242 --KLPSFQNS--SFNGR--------PPPISISPNKFSKP---------FTNASSRTP-------- 277

  Fly   285 PALTSYSFGAQD--FSSSGVMNSADIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATS---PVSIK 344
                     .|:  .::||..|:.:                      ||.|..|:.|   .:...
Yeast   278 ---------KQEHKINNSGSNNNDN----------------------SNYTQSPSNSLEDSIQQT 311

  Fly   345 VKAEPQSPPRDLSASG----HQQNSNGSTGS---GGSSSSTSSNASGGAGGGGAVSAANVITHLN 402
            |||.     |.|||..    ...|:|.|:.|   ...||::|::|:|.:.|...:...|..:..:
Yeast   312 VKAR-----RKLSARPVLRVRIPNNNFSSNSAIPSEPSSASSTSANGNSMGSSQIMKENKTSRSS 371

  Fly   403 NVSVLAGGPSG----QGGGGG------------GGGSNGNVEQATN--------LSVLSHAQQHH 443
            .:|.|:...||    |.|..|            .|.:|||.....|        .|.|..|.|.:
Yeast   372 KISPLSASASGPLTLQKGNNGRMVIKLPNANAPNGSNNGNGSNNNNHPYPFGSGSSPLFSATQPY 436

  Fly   444 LGMPNSRPSSTGHITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQ--------LGDYDAPNHKR 500
            :..| .:||:      .||.|.......||....||.||...::|.        |..........
Yeast   437 IATP-LQPSN------IPGGPFQQNTSFLAQRQTQQYQQMSFKKQSQTVPLTTTLTGRPPSTFSG 494

  Fly   501 PRISGG--WGTXPAR---------------------AAGSSHYKPHHNNNTGC-----SSINGSN 537
            |..|.|  .|:.|::                     :.|.:..||.:.||.|.     :::|..|
Yeast   495 PETSNGPPTGSLPSKFVHDLMSNSPNVSSISMFPDWSMGPNSAKPGNTNNPGTFPPVQTAVNNGN 559

  Fly   538 TS--CSTNNTITSSSNSSSSSN 557
            :|  .|||||..:::|::::|:
Yeast   560 SSNISSTNNTNNNNNNNNNNSS 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	39/88 (44%)
		HJURP_C	95..155	CDD:289143	8/63 (13%)
RLM1	NP_015236.1	MADS_MEF2_like	2..77	CDD:238165	37/74 (50%)
		ARG80	146..673	CDD:227400	117/519 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344600
Domainoid	1	1.000	63	1.000	Domainoid score	I2467
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1566
Isobase	1	0.950	-	0	Normalized mean entropy	S2674
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm46595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830