DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mef2 and Mef2d

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_006232833.1	Gene:	Mef2d / 81518	RGDID:	621489	Length:	514	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	168/507 - (33%)
Similarity:	227/507 - (44%)	Gaps:	151/507 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||.||||||||||||.|||||:||||||||||||||||||||:.||||:||||||||:|
  Rat     1 MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTL--TPRTEAKYNKIDEEFQNMMQR 128
            |||||||||||||.||.:|||...|.|....||||.:.:.:|  :|..|.||.:..||...:.:|
  Rat    66 LLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRR 130

  Fly   129 NQMAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTN------------------I 175
            .     |:..|  .||  :.:||:|||..       |:|.|.|:.:                  :
  Rat   131 Y-----GSSVP--APN--FAMPVTVPVSN-------QSSMQFSNPSSSLVTPSLVTSSLTDPRLL 179

  Fly   176 SPRPSSSETDSVYP--------SGSML-------------EMSNGYPHSHSPLVGSPSPGPSP-- 217
            ||:..:.:.:||.|        :|:||             .:.|||..:.:      |||..|
  Rat   180 SPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARA------SPGLLPVA 238

  Fly   218 ---GIAHHLSIKQQSPGSQN------GRASNLRVVIPPTIAPIPPNMSAPD-DVGYADQ---RQS 269
               |:...:..|...|.:.|      .|..:|||:.......:..:::... |:..|.:   .||
  Rat   239 NGNGLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLTEDHLDLNNAQRLGVSQS 303

  Fly   270 QTSLNTPVVTLQTP-----------IPAL--TSYSFGAQDFSSSGVMNSADIMSL---NTWHQ-- 316
            ..||.||||::.||           :|..  |.|...:.:.||....:|...::|   ..|.|
  Rat   304 THSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPSAELSSLPAFSSPAGLALGNVTAWQQPQ 368

  Fly   317 --------------------------------------GLVPHSSLSHL--AVSNSTPPPATSPV 341
                                                  .|:|.|.|.|:  |::.:|.|
  Rat   369 QPQQPQPPQPPQSQPQPPQPQPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAALTVTTHP------ 427

  Fly   342 SIKVKAEPQSPPRDLS---------ASGHQQNSNGSTGSGGSSSSTSSNASG 384
            .|.:|:||.||.|:.|         .:...:...|.:...|.|..|.....|
  Rat   428 HISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	19/61 (31%)
Mef2d	XP_006232833.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
Mef2d	XP_006232833.1	HJURP_C	97..151	CDD:403531	21/69 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7504
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3108
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm44768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970