DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mef2 and mef2d

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001072927.1	Gene:	mef2d / 780389	XenbaseID:	XB-GENE-483879	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	188/489 - (38%)
Similarity:	235/489 - (48%)	Gaps:	135/489 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||.||||||||||||.|||||:||||||||||||||||||||:.||||:||||||||:|
Frog     1 MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTL--TPRTEAKYNKIDEEFQNMMQR 128
            |||||||||||||.||.:|||...|.|....||||.:.|.::  :|..|.||.|..|:...:.:|
Frog    66 LLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGDDSIDQSPLMEDKYRKASEDLDILFKR 130

  Fly   129 NQMAIGGAGAPRQLPNSSYTLPVSVPV----------PG-----------SYGDNLLQASPQ--M 170
            ...|:         |..::.:||:|||          ||           |..|..|.:.||  :
Frog   131 YGSAV---------PAPNFAMPVTVPVTNQNALQFSNPGGSLVTQSLMTSSLTDPRLLSPPQPAL 186

  Fly   171 SHTNISP----RPSSSETDSVYPSGSML--EMSNGYPHSHSPL-VGSPSPGPSPGIAHHLSIKQQ 228
            ....:||    ||:|        :|:||  |::|......||: .|..|...|||:.
Frog   187 QRNTVSPGLPQRPAS--------AGAMLGGELNNSNGTCPSPVGNGYISARASPGLI-------- 235

  Fly   229 SPGSQNGRASNLRVVIPPTIAPIPPNMSA--------PD-------------------DVGYADQ 266
             |.| ||  ::|..|||.. :|.|||.::        ||                   .:..:.|
Frog   236 -PVS-NG--NSLGKVIPAK-SPPPPNQNSQLGANSRKPDLRVITSQGGKGLMHHLTEEQLEMSAQ 295

  Fly   267 R-----QSQTSLNTPVVTLQTP------------IPAL--TSYSFGAQDFSSSGVMNSADIMSL- 311
            |     |:..||.||||::.||            :|..  |.|...:.|.||....:|...:||
Frog   296 RLGGVSQAAHSLTTPVVSVATPSLLSHHGLPFSAMPTAYNTDYQLTSADLSSLSTFSSPSSLSLG 360

  Fly   312 --NTW---------HQG--LVPHSSLSHLAVSNSTPPPATSPV----SIKVKAEPQSPPRD---- 355
              ..|         ||.  |:| .|||:|..|...|..||..|    :|.:|.||.||.|:
Frog   361 NVTAWQQQQQQQHHHQAQQLIP-VSLSNLVSSGQLPHTATLTVNTNPNISIKKEPPSPNRERSTG 424

  Fly   356 --LSASGHQQNSNGSTGSGGSSSSTSSNASGGAG 387
              ||:..||  |...........|.|||||...|
Frog   425 TPLSSFPHQ--SRHEVTGRSPVDSLSSNASSFEG 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	17/61 (28%)
mef2d	NP_001072927.1	ARG80	1..278	CDD:227400	135/306 (44%)
mef2d	NP_001072927.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7556
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm47806
Panther	1	1.100	-	-	O	PTHR11945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160