DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mef2 and SRF

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_003122.1	Gene:	SRF / 6722	HGNCID:	11291	Length:	508	Species:	Homo sapiens

Alignment Length:	388	Identity:	94/388 - (24%)
Similarity:	155/388 - (39%)	Gaps:	100/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRVL 66
            ||.||::..|.::..|..||:|||.|:||||||||.|...::.|::.|.:..:|.:|:..:..::
Human   142 GRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMI 206

  Fly    67 LKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAK-YNKIDEEFQNMMQRNQ 130
                      .|.|.|.:|:    ..:.||||| ..:|.|...|..|. :.:.|..:|      .
Human   207 ----------TSETGKALIQ----TCLNSPDSP-PRSDPTTDQRMSATGFEETDLTYQ------V 250

  Fly   131 MAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHT-NISPRPSSSETD-------SV 187
            .....:|..:.....::|:   ..:||:  .:.:|.:|..|.| .:|..||...|:       ||
Human   251 SESDSSGETKDTLKPAFTV---TNLPGT--TSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASV 310

  Fly   188 YPS------GSMLEMSNGYPHSHSPLVGSPS-----PG-------PSPGIAHHLSIKQQSPGSQN 234
            .||      |::|:.:...|.|...|:..|:     ||       |...|..|.:.:|.||...:
Human   311 SPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDS 375

  Fly   235 G-----RASNLRVVIPPTI--APIPPNMS------APDDVGYA---------------------- 264
            .     .:|:..|.:|.||  :.:|..:.      :|..|.||
Human   376 STDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPST 440

  Fly   265 ---DQRQSQTSLNTPVV-------TLQTPIPALTSYSFG--AQDFSSSGVMNSADIMSLNTWH 315
               ...|.|.....|.|       |:|.|:.|:..:...  .|...||..:....:::|:|.|
Human   441 MQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	25/75 (33%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	13/60 (22%)
SRF	NP_003122.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		MADS_SRF_like	142..223	CDD:238166	30/94 (32%)
		Involved in dimerization	168..222		17/67 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..240		9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..385		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810