DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mef2 and Mef2c

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_038959332.1	Gene:	Mef2c / 499497	RGDID:	1563119	Length:	483	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	208/596 - (34%)
Similarity:	276/596 - (46%)	Gaps:	200/596 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
  Rat     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIE---KENKNGVMSPD-----------------SPEAETDYTLTPR 110
            |||||||||||||.||.:|:|   |:..||..|||                 ||:.::.|.||||
  Rat    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGSESPDPDSSYALTPR 130

  Fly   111 TEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVP-----------GSYGD-NL 163
            ||.||.||:|||.||::.:::.        .:|..::.:||::||.           .|.|: ||
  Rat   131 TEEKYKKINEEFDNMIKSHKIP--------AVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNL 187

  Fly   164 LQ-ASPQMSHTNISP-----RPSSSETDSV----YPSGSMLEMSNGYPHSHSPLVGSP--SPG-- 214
            |. |.|.:...::||     .||:..|..:    ..||:.....|||        |:|  |||
  Rat   188 LPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGY--------GNPRNSPGLL 244

  Fly   215 PSPGIAHHLSIKQQSPG----SQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQT 271
            .|||..:. :|:.:||.    ..|.|..:|||:|||......|::         :||    ||..
  Rat   245 VSPGNLNK-NIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSV---------NQRINNSQSAQ 299

  Fly   272 SLNTPVVTLQTP-IPAL--------------TSYSFGAQDFSSSGVMNSADIMSLNT---W---H 315
            ||.||||::.|| :|..              |.||..:.|.||....|:|..:.|.:   |   |
  Rat   300 SLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQH 364

  Fly   316 QGLVPHSSLS--------HLAVSNSTPPPATSPVSIKVKAEPQSPPRD--LSASGHQQNSNGSTG 370
            ...:|.|:||        ||:.|::...|:|.  |:.:|:||.|||||  .:.|.:.|::....|
  Rat   365 LHNMPPSALSQLGACTSTHLSQSSNLSLPSTQ--SLNIKSEPVSPPRDRTTTPSRYPQHTRHEAG 427

  Fly   371 SG--GSSSSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATNL 433
            ..  .|.||.||:..|
  Rat   428 RSPVDSLSSCSSSYDG------------------------------------------------- 443

  Fly   434 SVLSHAQQHHLGMPNSRPSSTGHITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPNH 498
               |..:.|.    |...|..|...|:|       |.|                      ::|:.
  Rat   444 ---SDREDHR----NEFHSPIGLTRPSP-------DER----------------------ESPSV 472

  Fly   499 KRPRISGGWGT 509
            ||.|:|.||.|
  Rat   473 KRMRLSEGWAT 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	24/76 (32%)
Mef2c	XP_038959332.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
Mef2c	XP_038959332.1	HJURP_C	116..170	CDD:403531	23/61 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7504
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31087
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3108
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm44768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.970