Protein Alignment Mef2 and MEF2D

DIOPT Version :10

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_005911.1
• Gene: MEF2D / 4209
• HGNCID: 6997
• Length: 521
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 170/525 - (32%)
• Similarity: 226/525 - (43%)
• Gaps: 180/525 - (34%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||.||||||||||||.|||||:||||||||||||||||||||:.||||:||||||||:|
Human     1 MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTL--TPRTEAKYNKIDEEFQNMMQR 128
            |||||||||||||.||.:|||...|.|....||||.:.:.:|  :|..|.||.:..||...:.:|
Human    66 LLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRR 130

  Fly   129 NQMAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTN------------------I 175
            ....:         |..::.:||:|||..       |:|.|.|:.:                  :
Human   131 YGSTV---------PAPNFAMPVTVPVSN-------QSSLQFSNPSGSLVTPSLVTSSLTDPRLL 179

  Fly   176 SPRPSSSETDSVYP--------SGSM----LEMSNGYPHSHSPLVGSPSPGPSPGIAHHLSIKQQ 228
            ||:..:.:.:||.|        :|:|    |..:||         ..|||     :.:.....:.
Human   180 SPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANG---------ACPSP-----VGNGYVSARA 230

  Fly   229 SPG---SQNGRASNLRVVIPPTIAPIPPNMSA--------PD---------------------DV 261
            |||   ..||.:.| :|:  |..:|.||..|.        ||                     |:
Human   231 SPGLLPVANGNSLN-KVI--PAKSPPPPTHSTQLGAPSRKPDLRVITSQAGKGLMHHLTEDHLDL 292

  Fly   262 GYADQ---RQSQTSLNTPVVTLQTP-----------IPAL--TSYSFGAQDFSSSGVMNSADIMS 310
            ..|.:   .||..||.||||::.||           :|..  |.|...:.:.||....:|...:|
Human   293 NNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLTSAELSSLPAFSSPGGLS 357

  Fly   311 L---NTWHQ-----------------------------------------------GLVPHSSLS 325
            |   ..|.|                                               .|:|.|.|.
Human   358 LGNVTAWQQPQQPQQPQQPQPPQQQPPQPQQPQPQQPQQPQQPPQQQSHLVPVSLSNLIPGSPLP 422

  Fly   326 HL--AVSNSTPPPATSPVSIKVKAEPQSPPRDLS---------ASGHQQNSNGSTGSGGSSSSTS 379
            |:  |::.:|.|      .|.:|:||.||.|:.|         .:...:..:|.:...|.|..|.
Human   423 HVGAALTVTTHP------HISIKSEPVSPSRERSPAPPPPAVFPAARPEPGDGLSSPAGGSYETG 481

  Fly   380 SNASG 384
            ....|
Human   482 DRDDG 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	ARG80	1..>203	CDD:227400	110/233 (47%)
		MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
MEF2D	NP_005911.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
		HJURP_C	97..154	CDD:463543	19/72 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..207		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..266		7/24 (29%)
		Beta domain	286..292		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..407		4/49 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..521		12/50 (24%)