Protein Alignment Mef2 and MEF2C

DIOPT Version :9

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001180276.1
• Gene: MEF2C / 4208
• HGNCID: 6996
• Length: 483
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 208/595 - (34%)
• Similarity: 275/595 - (46%)
• Gaps: 198/595 - (33%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
Human     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIE---KENKNGVMSPD-----------------SPEAETDYTLTPR 110
            |||||||||||||.||.:|:|   |:..||..|||                 ||:.::.|.||||
Human    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGCESPDPDSSYALTPR 130

  Fly   111 TEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVP-----------GSYGD-NL 163
            ||.||.||:|||.||::.:::.        .:|..::.:|||:||.           .|.|: ||
Human   131 TEEKYKKINEEFDNMIKSHKIP--------AVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNL 187

  Fly   164 LQ-ASPQMSHTNISP-----RPSSSETDSV----YPSGSMLEMSNGYPHSHSPLVGSP--SPG-- 214
            |. |.|.:...::||     .||:..|..:    ..||:.....|||        |:|  |||
Human   188 LPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGY--------GNPRNSPGLL 244

  Fly   215 PSPG-IAHHLSIKQQSPGS--QNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQTS 272
            .||| :..::..|...|.:  .|.|..:|||:|||......|::         :||    ||..|
Human   245 VSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSV---------NQRINNSQSAQS 300

  Fly   273 LNTPVVTLQTP-IPAL--------------TSYSFGAQDFSSSGVMNSADIMSLNT---W---HQ 316
            |.||||::.|| :|..              |.||..:.|.||....|:|..:.|.:   |   |.
Human   301 LATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHL 365

  Fly   317 GLVPHSSLS--------HLAVSNSTPPPATSPVSIKVKAEPQSPPRD--LSASGHQQNSNGSTGS 371
            ..:|.|:||        ||:.|::...|:|.  |:.:|:||.|||||  .:.|.:.|::....|.
Human   366 HNMPPSALSQLGACTSTHLSQSSNLSLPSTQ--SLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGR 428

  Fly   372 G--GSSSSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATNLS 434
            .  .|.||.||:..|
Human   429 SPVDSLSSCSSSYDG-------------------------------------------------- 443

  Fly   435 VLSHAQQHHLGMPNSRPSSTGHITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPNHK 499
              |..:.|.    |...|..|...|:|       |.|                      ::|:.|
Human   444 --SDREDHR----NEFHSPIGLTRPSP-------DER----------------------ESPSVK 473

  Fly   500 RPRISGGWGT 509
            |.|:|.||.|
Human   474 RMRLSEGWAT 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	95..155	CDD:289143	25/76 (33%)
MEF2C	NP_001180276.1	ARG80	1..263	CDD:227400	131/277 (47%)
		MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	117..170	CDD:403531	24/60 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7673
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31087
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3106
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm40628
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.960