DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mef2 and BORCS8-MEF2B

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_005910.1	Gene:	BORCS8-MEF2B / 4207	HGNCID:	39979	Length:	365	Species:	Homo sapiens

Alignment Length:	433	Identity:	152/433 - (35%)
Similarity:	189/433 - (43%)	Gaps:	110/433 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            |||||||||||.|:|||||||.|||||:||||||||||||||||||||:|:|:|:||||||||||
Human     1 MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQ 130
            |||||||:|||||.||.:|:|...:.|: ..|.||.|.|            :..||.....:|
Human    66 LLKYTEYSEPHESRTNTDILETLKRRGI-GLDGPELEPD------------EGPEEPGEKFRR-- 115

  Fly   131 MAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTNISPRPSSSETDSVY------- 188
              :.|.|....||.                ..|..|:|.|      |.|     |.||
Human   116 --LAGEGGDPALPR----------------PRLYPAAPAM------PSP-----DVVYGALPPPG 151

  Fly   189 --PSGSMLEMSNGYPHSHSP---LVGSPSPGPSPGIAH------HLSIKQQSP--GSQNGRASNL 240
              |||    :....|....|   ...:|..|| ||:.|      ||:.|...|  ....||.|:|
Human   152 CDPSG----LGEALPAQSRPSPFRPAAPKAGP-PGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDL 211

  Fly   241 RVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPIPALTSYSF-------GAQDFS 298
                       |..::.|.. |....|...:.|..|..| .||.|.|.|:.|       ||:.::
Human   212 -----------PGGLAGPRG-GLNTSRSLYSGLQNPCST-ATPGPPLGSFPFLPGGPPVGAEAWA 263

  Fly   299 SSGVMNSADIMSLNTWHQGLVPHSSLSHLAVSNSTP-PPAT----SPVSIKVKAEPQS-----PP 353
            ......:|....         |..|.|.|:.|...| .|||    ||:........||     ||
Human   264 RRVPQPAAPPRR---------PPQSASSLSASLRPPGAPATFLRPSPIPCSSPGPWQSLCGLGPP 319

  Fly   354 RDLSASGHQQNSNGSTGSGGSSSSTSSNASGGAGGGGAVSAAN 396
              .:.........|....||:|...|...:...|...::.|::
Human   320 --CAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASS 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	66/75 (88%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	12/59 (20%)
BORCS8-MEF2B	NP_005910.1	MADS_MEF2_like	2..78	CDD:238165	66/75 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..124		10/45 (22%)
		Atrophin-1	<123..364	CDD:331285	68/294 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..309		48/193 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..365		7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7673
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840