DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mef2 and MEF2A

DIOPT Version :9

Sequence 1:NP_001260842.1 Gene:Mef2 / 36032 FlyBaseID:FBgn0011656 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_001352130.1 Gene:MEF2A / 4205 HGNCID:6993 Length:511 Species:Homo sapiens


Alignment Length:437 Identity:187/437 - (42%)
Similarity:244/437 - (55%) Gaps:86/437 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|||||:||||||||:|
Human     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQ 130
            |||||||||||||.||.:|:|..||......|||:.:|.|.|||.||.||.||:|||.|||:.::
Human    66 LLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHK 130

  Fly   131 MAIG-GAGAPRQLPNSSYTLPVSVPVPGSY---GDNLLQAS---------------PQMS-HTNI 175
            :|:. ..|.|.|..:.|.|:||:.|...||   |.:|:..|               ||.: |.|:
Human   131 IAVSTKPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSPPQTTLHRNV 195

  Fly   176 SP----RPSS--------SETDSVYPSGS-MLEMSNGYPHSH-SP-LVGS----------PSPGP 215
            ||    ||.|        |.||...|:|: ...:.||:.:|. || |:|:          |:..|
Human   196 SPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSP 260

  Fly   216 SPGIAHHLSIKQQSPG----SQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQTS 272
            .|            ||    ..|.|..:|||||||:...:.|.:|..:::....||    |:...
Human   261 PP------------PGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQRISSSQATQP 313

  Fly   273 LNTPVVTLQTP-----------IPAL--TSYSFGAQDFSSSGVMNSADIMSL---NTWHQGLVPH 321
            |.||||::.||           :|..  |.||..:.|.|:....||..::||   :.|.|..:..
Human   314 LATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQ 378

  Fly   322 SSLSHLA----VSNSTPPPATSPVSIKVKAEPQSPPRD-LSASGHQQ 363
            ::||.|.    :|..:.....:..:|.:|:||.||||| ::.||.||
Human   379 AALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQ 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mef2NP_001260842.1 MADS_MEF2_like 2..78 CDD:238165 68/75 (91%)
HJURP_C 95..155 CDD:289143 28/60 (47%)
MEF2ANP_001352130.1 MADS_MEF2_like 2..78 CDD:238165 68/75 (91%)
HJURP_C 97..156 CDD:315100 28/58 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..233 15/55 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..274 6/38 (16%)
Required for interaction with MAPKs 270..287 9/16 (56%)
Beta domain 293..300 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..511 13/25 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I7673
eggNOG 1 0.900 - - E1_COG5068
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 261 1.000 Inparanoid score I3106
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D320201at33208
OrthoFinder 1 1.000 - - FOG0000108
OrthoInspector 1 1.000 - - otm40628
orthoMCL 1 0.900 - - OOG6_103662
Panther 1 1.100 - - O PTHR11945
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1041
SonicParanoid 1 1.000 - - X116
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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