DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mef2 and mef2ca

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_005169286.1	Gene:	mef2ca / 30575	ZFINID:	ZDB-GENE-980526-253	Length:	473	Species:	Danio rerio

Alignment Length:	442	Identity:	184/442 - (41%)
Similarity:	241/442 - (54%)	Gaps:	83/442 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
Zfish     1 MGRKKIQIARIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAET-DYTLTPRTEAKYNKIDEEFQNMMQRN 129
            |||||||||||||.||.:|:|...|.|:...|||:.:. |...:|.:|.||.||:|:...|:.|.
Zfish    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDIDAEDSGHSPESEDKYRKINEDIDLMISRQ 130

  Fly   130 QMAIGGAGAPRQLPNSSYTLPVSVPV--PGS--YG--------DNLLQAS-PQMSHTNISP---- 177
            ::.        .:|.|:|.:|||:||  |.|  ||        .|||..: |.:...::||
Zfish   131 RLC--------AIPQSNYDMPVSIPVSNPNSLIYGHPGASLGNPNLLPLTHPSLQRNSMSPGVTH 187

  Fly   178 -RPSSSETDSVYP----SGSMLEMSNGY-PHSHSP--LVGSPSPGPSPGIAHHLSIKQQSPGSQN 234
             .||:..|..:..    ||:.....||| .|.:||  ||   |||   .::.:|..|  ||.|.|
Zfish   188 RPPSAGNTGGLMAADLGSGAGTSTGNGYGNHRNSPGLLV---SPG---NMSKNLQAK--SPPSMN 244

  Fly   235 ---GRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQTSLNTPVVTLQTP--------- 283
               .|..:|||:|||......|::|...|: ..:||    ||..||:||||::.||
Zfish   245 MSLSRKPDLRVLIPPGAKNTMPSISEDVDM-LLNQRISSSQSAQSLSTPVVSVATPTLPGEVMGG 308

  Fly   284 IPAL------TSYSFGAQDFSSSGVMNSA---DIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATS 339
            .|:.      |.||..:.|.||....||:   .:.|:..|.|.: .||.|.||...:|.....:|
Zfish   309 YPSAINTSYGTEYSLSSGDLSSLSAFNSSASLHLGSMTGWPQNM-QHSGLGHLGNCSSAQLCQSS 372

  Fly   340 PVS------IKVKAEPQSPPRDLSASGHQQNSNGSTGSGGSSSSTSSNASGG 385
            .:|      :.:|:||.|||||        .::|:.|..|....|......|
Zfish   373 ALSLPSNQNLHIKSEPVSPPRD--------RASGTPGLYGVPQQTPLRQDSG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	19/60 (32%)
mef2ca	XP_005169286.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
mef2ca	XP_005169286.1	HJURP_C	98..152	CDD:289143	20/61 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7654
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3261
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm24702
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.100