DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mef2 and mbx2

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_596507.1	Gene:	mbx2 / 2540350	PomBaseID:	SPBC317.01	Length:	372	Species:	Schizosaccharomyces pombe

Alignment Length:	408	Identity:	107/408 - (26%)
Similarity:	155/408 - (37%)	Gaps:	104/408 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||.|:.|||:|:|.|||.|||.|:.||||||:||.|||:|:.:.....:|:.:.|:|..|.
pombe     1 MGRKKISIAPITDDRSRSVTFVKRKQGLYKKAYELAVLADCEVAVTVIDRKGRLHVFCSSDYQRT 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEA--------KYNKIDEEF 122
            |          :.|...:|.|.:|::...|  ||..|:. |::|.|..        |:.|..::
pombe    66 L----------QQLNTLSIYELKNRSHFSS--SPVEESS-TVSPETTTGSFTPLNNKHLKSQDQ- 116

  Fly   123 QNMMQRNQMAIGGAGAPRQLPNSSYTLPV-SVPVPGSYGDNLLQASPQM---SHTNISPRPSSSE 183
              .:..:|:..|.:.|..:.....|...| |...|.....|.:::.|..   .|.:...||..
pombe   117 --PLSDSQLDTGDSPATSETTVQDYNPQVQSYCRPEPLSSNHVRSCPPFPPTQHHHPHTRPPH-- 177

  Fly   184 TDSVYPSGSMLEMSNGYPHSHSPLVGSP-------SPGPSPGIAHHLSIKQQSP-GSQNG----- 235
                :|.         :||.|:.....|       |||.:..:.||      || .|.||
pombe   178 ----HPP---------HPHFHNNNYPPPYCFQSPVSPGATVPLQHH------SPYPSDNGFPGHR 223

  Fly   236 RASNLRVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPIPALTSYSFGAQDFSSS 300
            |.::......|..|..|.....|..:|....:|.|::.:..|  |..|    .||......::..
pombe   224 RQTHFAPYYYPQRATSPSLKQVPTYLGTHVLQQDQSTYDQKV--LMPP----ASYLSSPNQYTLK 282

  Fly   301 GVM--NSADIMSLNTWHQGLVPHSSLSHLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQ 363
            .|.  |.|            .|.....|       |.|..:|....||.....||
pombe   283 NVSPGNPA------------CPPFLYEH-------PNPQLTPEMFDVKQGSPIPP---------- 318

  Fly   364 NSNGSTGSGGSSSSTSSN 381
                 |...|||..||.:
pombe   319 -----TAYSGSSCETSQH 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	35/75 (47%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	15/68 (22%)
mbx2	NP_596507.1	ARG80	1..372	CDD:227400	107/408 (26%)
mbx2	NP_596507.1	MADS_SRF_like	2..82	CDD:238166	39/89 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	81	1.000	Inparanoid score	I1852
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		oto100717
orthoMCL	1	0.900	-	-		OOG6_103662
Panther	1	1.100	-	-	LDO	PTHR11945
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.940