Protein Alignment Mef2 and Mef2c

DIOPT Version :9

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_011242797.1
• Gene: Mef2c / 17260
• MGIID: 99458
• Length: 484
• Species: Mus musculus
• Alignment Length: 597
• Identity: 206/597 - (34%)
• Similarity: 275/597 - (46%)
• Gaps: 201/597 - (33%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
Mouse     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIE---KENKNGVMSPD-----------------SPEAETDYTLTPR 110
            |||||||||||||.||.:|:|   |:..||..|||                 ||:.::.|.||||
Mouse    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSALNKKENKGSESPDPDSSYALTPR 130

  Fly   111 TEAKYNKIDEEFQNMMQRNQMAIGGAGAPRQLPNSSYTLPVSVPVP-----------GSYGD-NL 163
            ||.||.||:|||.||::.:::.        .:|..|:.:||::||.           .:.|: ||
Mouse   131 TEEKYKKINEEFDNMIKSHKIP--------AVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNL 187

  Fly   164 LQ-ASPQMSHTNISP-----RPSSSETDSV----YPSGSMLEMSNGYPHSHSPLVGSP--SPG-- 214
            |. |.|.:...::||     .||:..|..:    ..||:.....|||        |:|  |||
Mouse   188 LPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGY--------GNPRNSPGLL 244

  Fly   215 PSPGIAHHLSIKQQSPG----SQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQT 271
            .|||..:. :|:.:||.    ..|.|..:|||:|||......|::         :||    ||..
Mouse   245 VSPGNLNK-NIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSV---------NQRINNSQSAQ 299

  Fly   272 SLNTPVVTLQTP-IPAL--------------TSYSFGAQDFSSSGVMNSADIMSLNT---W---H 315
            ||.||||::.|| :|..              |.||..:.|.||....|:|..:.|.:   |   |
Mouse   300 SLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQH 364

  Fly   316 QGLVPHSSLS--------HLAVSNSTPPPATSPVSIKVKAEPQSPPRDLSASGHQQNSNGSTGSG 372
            ...:|.|:||        ||:.|::...|:|.  |:.:|:||.|||||.:.:..:...:.:....
Mouse   365 LHNMPPSALSQLGACTSTHLSQSSNLSLPSTQ--SLSIKSEPVSPPRDRTTTPSRYPQHTTRHEA 427

  Fly   373 GSS-----SSTSSNASGGAGGGGAVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATN 432
            |.|     ||.||:..|
Mouse   428 GRSPVDSLSSCSSSYDG------------------------------------------------ 444

  Fly   433 LSVLSHAQQHHLGMPNSRPSSTGHITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPN 497
                |..:.|.    |...|..|...|:|       |.|                      ::|:
Mouse   445 ----SDREDHR----NEFHSPIGLTRPSP-------DER----------------------ESPS 472

  Fly   498 HKRPRISGGWGT 509
            .||.|:|.||.|
Mouse   473 VKRMRLSEGWAT 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	95..155	CDD:289143	25/76 (33%)
Mef2c	XP_011242797.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	116..170	CDD:372061	24/61 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7664
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31087
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3301
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm42703
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.960