DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mef2 and Mef2a

DIOPT Version :9

Sequence 1:	NP_001260842.1	Gene:	Mef2 / 36032	FlyBaseID:	FBgn0011656	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001344253.1	Gene:	Mef2a / 17258	MGIID:	99532	Length:	500	Species:	Mus musculus

Alignment Length:	476	Identity:	189/476 - (39%)
Similarity:	248/476 - (52%)	Gaps:	115/476 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|||||:||||||||:|
Mouse     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQ 130
            |||||||||||||.||.:|:|..||......|||:.:|.|.|||.||.||.||:|||.|||:.::
Mouse    66 LLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHK 130

  Fly   131 MAIGGAGAPRQLPNSSYTLPVSVPV----------PGS-------------YGDNLLQASPQMSH 172
            :|.|       ||..::::.|:|||          |||             ...::|...|...|
Mouse   131 IAPG-------LPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLADSSMLSPPPATLH 188

  Fly   173 TNISP----RPSS--------SETDSVYPSGS-MLEMSNGYPHSH-SP-LVGS----------PS 212
            .|:||    ||.|        |.||...|:|: ...:.||:.:|. || |:|:          |:
Mouse   189 RNVSPGAPQRPPSTGSASGMLSTTDLTVPNGAGNSPVGNGFVNSRASPNLIGNTGANSLGKVMPT 253

  Fly   213 PGPSPGIAHHLSIKQQSPG----SQNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QS 269
            ..|.|            ||    ..|.|..:|||||||:...:.|.:|..:::....||    |:
Mouse   254 KSPPP------------PGGGSLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNAQRISSSQA 306

  Fly   270 QTSLNTPVVTLQTP-----------IPAL--TSYSFGAQDFSSSGVMNSADIMSL---NTWHQGL 318
            ...|.||||::.||           :|..  |.||..:.|.|:.....|..::||   :.|.|..
Mouse   307 TQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHH 371

  Fly   319 VPHSSLSHLA----VSNSTPPPATSPVSIKVKAEPQSPPRD-LSASGHQQNSN------------ 366
            :..::||.|.    :|..:.....:..:|.:|:||.||||| ::.||.||...
Mouse   372 LGQAALSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFQQQQQQPQQQPPPQPPQ 436

  Fly   367 -------GSTGSGGSSSSTSS 380
                   |.:.....|||:||
Mouse   437 PQPRQEMGRSPVDSLSSSSSS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
Mef2	NP_001260842.1	HJURP_C	95..155	CDD:289143	26/59 (44%)
Mef2a	NP_001344253.1	MADS_MEF2_like	2..78	CDD:238165	68/75 (91%)
Mef2a	NP_001344253.1	HJURP_C	97..151	CDD:403531	28/60 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7664
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3301
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D320201at33208
OrthoFinder	1	1.000	-	-		FOG0000108
OrthoInspector	1	1.000	-	-		otm42703
orthoMCL	1	0.900	-	-		OOG6_103662
Panther	1	1.100	-	-	O	PTHR11945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1041
SonicParanoid	1	1.000	-	-		X116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860