Protein Alignment Mef2 and MEF2B

DIOPT Version :10

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001139257.1
• Gene: MEF2B / 100271849
• HGNCID: 6995
• Length: 368
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 146/392 - (37%)
• Similarity: 180/392 - (45%)
• Gaps: 107/392 - (27%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            |||||||||||.|:|||||||.|||||:||||||||||||||||||||:|:|:|:||||||||||
Human     1 MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTLTPRTEAKYNKIDEEFQNMMQRNQ 130
            |||||||:|||||.||.:|:|...:.|: ..|.||.|.|            :..||.....:|
Human    66 LLKYTEYSEPHESRTNTDILETLKRRGI-GLDGPELEPD------------EGPEEPGEKFRR-- 115

  Fly   131 MAIGGAGAPRQLPNSSYTLPVSVPVPGSYGDNLLQASPQMSHTNISPRPSSSETDSVY------- 188
              :.|.|....||.                ..|..|:|.|      |.|     |.||
Human   116 --LAGEGGDPALPR----------------PRLYPAAPAM------PSP-----DVVYGALPPPG 151

  Fly   189 --PSGSMLEMSNGYPHSHSP---LVGSPSPGPSPGIAH------HLSIKQQSP--GSQNGRASNL 240
              |||    :....|....|   ...:|..|| ||:.|      ||:.|...|  ....||.|:|
Human   152 CDPSG----LGEALPAQSRPSPFRPAAPKAGP-PGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDL 211

  Fly   241 RVVIPPTIAPIPPNMSAPDDVGYADQRQSQTSLNTPVVTLQTPIPALTSYSF---GAQDFS---- 298
                       |..::.|.. |....|...:.|..|..| .||.|.|.|:.|   |..::.
Human   212 -----------PGGLAGPRG-GLNTSRSLYSGLQNPCST-ATPGPPLGSFPFLPGGPPEYGLGDP 263

  Fly   299 --SSGVMNSADIMSLNTWH--QGLVPHSSLSH----LAVSNSTPP-----PATSPVSIKVKAEPQ 350
              ..|::...   :|..|.  :|..|.:..|.    .::....||     |.|.||||  |:|..
Human   264 PPPPGLLQPP---TLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSI--KSERL 323

  Fly   351 SP 352
            ||
Human   324 SP 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	ARG80	1..>203	CDD:227400	99/210 (47%)
		MADS_MEF2_like	2..78	CDD:238165	66/75 (88%)
MEF2B	NP_001139257.1	MADS_MEF2_like	2..78	CDD:238165	66/75 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..124		10/45 (22%)
		PHA03247	<97..364	CDD:223021	71/295 (24%)