Protein Alignment Mef2 and mef2c

DIOPT Version :10

• Sequence 1: NP_001260842.1
• Gene: Mef2 / 36032
• FlyBaseID: FBgn0011656
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_012823888.1
• Gene: mef2c / 100127198
• XenbaseID: XB-GENE-486958
• Length: 472
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 205/574 - (35%)
• Similarity: 274/574 - (47%)
• Gaps: 167/574 - (29%)

  Fly     1 MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDRV 65
            ||||||||:||.|||||||||.|||||:||||||||||||||||||||:|:|||:||||||||:|
 Frog     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65

  Fly    66 LLKYTEYNEPHESLTNKNIIEKENKNGVMSPDSPEAETDYTL--TPRTEAKYNKIDEEFQNMMQR 128
            |||||||||||||.||.:|:|...|.|:...|||:.:.|.::  :|.:|.||.||:|:...|:.|
 Frog    66 LLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISR 130

  Fly   129 NQMAIGGAGAPRQLPNSSYTLPVSVPV--PGS--YGD--------NLLQAS-PQMSHTNISP--- 177
            .::.        .:|..::.:|||:||  |.|  |.:        |||..| |.:...::||
 Frog   131 QRLC--------AVPPPNFEMPVSIPVSNPNSLAYSNPAVSLGNHNLLPLSHPSLHRNSMSPGVT 187

  Fly   178 --RPSSSETDSV----YPSGSMLEMSNGY-PHSHSP--LVGSPSPGPSPGIAHHLSIKQQSPGS- 232
              .||:..|..:    ..:|:.....||| .|.:||  ||   |||   .:..::..|...|.:
 Frog   188 HRPPSAGNTGGLMGGDLTTGAGTSAGNGYGNHRNSPGLLV---SPG---NLNKNMQTKSPPPMNL 246

  Fly   233 -QNGRASNLRVVIPPTIAPIPPNMSAPDDVGYADQR----QSQTSLNTPVVTLQTP-IPAL---- 287
             .|.|..:|||:|||......|::|...|: ..:||    ||..||.||||.:.|| :|..
 Frog   247 GMNNRKPDLRVLIPPGSKNTMPSVSEDVDL-LLNQRINNSQSAQSLATPVVPVATPTLPGQGMGG 310

  Fly   288 ----------TSYSFGAQDFSS-SGVMNSA-DIMSLNTW---HQGLVPHSSLS--------HLAV 329
                      |.||..:.|.|| ||...|| .:.|:..|   |...:|||:||        ||:.
 Frog   311 YPTAISTTYGTEYSLSSADLSSLSGFNTSALHLGSVTGWQQHHLHNMPHSALSQLGACTSTHLSQ 375

  Fly   330 SNSTPPPATSPVSIKVKAEPQSPPRD--LSASGHQQNSNGSTGSG--GSSSSTSSNASGGAGGGG 390
            |::...|:|.  |:.:|:||.|||||  .:.||:.|::....|..  .|.||.||:..|
 Frog   376 SSNLSLPSTQ--SLHIKSEPVSPPRDRTTTPSGYPQHTRHEAGRSPVDSLSSCSSSYDG------ 432

  Fly   391 AVSAANVITHLNNVSVLAGGPSGQGGGGGGGGSNGNVEQATNLSVLSHAQQHHLGMPNSRPSSTG 455
                                                          |..:.|.    |...|..|
 Frog   433 ----------------------------------------------SDREDHR----NDFHSPIG 447

  Fly   456 HITPTPGAPSSDQDVRLAAVAVQQQQQQPHQQQQLGDYDAPNHKRPRISGGWGT 509
            ...|:|       |.|                      ::|:.||.|:|.||.|
 Frog   448 LTRPSP-------DER----------------------ESPSVKRMRLSEGWAT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mef2	NP_001260842.1	ARG80	1..>203	CDD:227400	112/226 (50%)
		MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
mef2c	XP_012823888.1	MADS_MEF2_like	2..78	CDD:238165	67/75 (89%)
		HJURP_C	<107..155	CDD:463543	16/55 (29%)