DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Etf-QO and etfdh

DIOPT Version :9

Sequence 1:	NP_001246231.1	Gene:	Etf-QO / 36031	FlyBaseID:	FBgn0286783	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001004598.1	Gene:	etfdh / 447859	ZFINID:	ZDB-GENE-040912-168	Length:	617	Species:	Danio rerio

Alignment Length:	601	Identity:	405/601 - (67%)
Similarity:	479/601 - (79%)	Gaps:	12/601 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HRVRRLFSPALARSISDVAKYPRITTHYTLNPREKDERWTEVDMERCVEEVDLVIVGGGPAGMSA 72
            |...:::|   .|..|.|   ||||||||:.||:||.||..|:|||..:|.|:||:||||||:||
Zfish    25 HVAPQIYS---TRWFSSV---PRITTHYTVYPRDKDSRWEGVEMERFADEADVVIIGGGPAGLSA 83

  Fly    73 AIRAKQLAAEKDQEIRVCVVEKAAEVGGHILSGAVIDPISLNELIPDWQEQGAPLNTPVTKDTFS 137
            |||.||||.:.::|:||||||||:::|.|.||||.::|.:||||||||:|:|||||||||:|.||
Zfish    84 AIRLKQLANQHEKELRVCVVEKASQIGAHTLSGACLEPTALNELIPDWKERGAPLNTPVTEDKFS 148

  Fly   138 FLTGSGRISIPVFKGWPMDNHGNYVVRLGHLVKWLGDQAEALGVEIYPGCAASEVLFHEDGSVKG 202
            .||...||.:|:..|.||:|||||:|||||.|:|||:|||.||||:|||.||:||||||||||||
Zfish   149 ILTEKYRIPVPILPGLPMNNHGNYLVRLGHFVRWLGEQAEELGVELYPGYAAAEVLFHEDGSVKG 213

  Fly   203 IATNDVGIAKSGAPKDTFARGMELHAKTTIFAEGCRGHLTKQIMQKFGLNEGSEPQAYGIGLKEV 267
            ||||||||||.|:|||.|.||||||||.|:|.|||.|||.||:.::|.|.|..|||.|.|||||:
Zfish   214 IATNDVGIAKDGSPKDVFERGMELHAKVTMFGEGCHGHLAKQLYKQFNLREKCEPQTYAIGLKEL 278

  Fly   268 WEIAPEKHQPGLVEHTIGWPLDRFTYGGSFLYHLNEPTPTIAVGFVVGLNYKNPWLSPFQEFQRF 332
            |.|..:|.:||..||::||||:|.||||:|||||||..|.:|:||||||:|.||::|||:||||:
Zfish   279 WVIDEKKWRPGRAEHSVGWPLNRNTYGGTFLYHLNEGEPLVALGFVVGLDYTNPYMSPFREFQRW 343

  Fly   333 KTHPKVRDVFEGATRIAYGARAINEGGFQSLPQKLSFPGGCLVGCSAGFLNVPRIKGSHYAMKSG 397
            |.||.|....||..||||||||:|||||||:|| |:||||.|:|||.||:|||:|||:|.|||||
Zfish   344 KHHPSVMSTLEGGNRIAYGARALNEGGFQSIPQ-LTFPGGMLIGCSPGFMNVPKIKGTHTAMKSG 407

  Fly   398 MLAAESAFEAI---NADAQSTAGVEPTGYAEKIKDSFVWKDLYSVRNVHPSFHNPLGLYGGLVLS 459
            |||||:||..|   |..:|:| |:....|.|.:|.|:|||:|.||||:.||||...|||||:|.:
Zfish   408 MLAAETAFSKITDENLQSQTT-GLYIPEYEEALKKSWVWKELRSVRNIRPSFHTYFGLYGGMVYT 471

  Fly   460 G-FSIFMGGREPWTLKHGPQDHESLKPASSCPPIVYPKPDGKISFDLLSSVALTGTNHEGDQPAH 523
            | |.....|:|||||||...|:..||||..|.||.||||||||||||||||||:|||||.|||||
Zfish   472 GIFYWIFRGKEPWTLKHSGSDYAQLKPAKDCSPIEYPKPDGKISFDLLSSVALSGTNHEHDQPAH 536

  Fly   524 LTLKDDRIPVDHNLALYEGPEQRFCPAGVYEYVPNEEGGNMKLQINAQNCIHCKTCDIKDPKQNI 588
            ||||||.|||..|||:|:||||||||||||||||.|.|..|:||||||||:||||||||||.|||
Zfish   537 LTLKDDSIPVSKNLAIYDGPEQRFCPAGVYEYVPLETGDGMRLQINAQNCVHCKTCDIKDPSQNI 601

  Fly   589 NWVVPEGGGGPAYNGM 604
            |||||||.||||||||
Zfish   602 NWVVPEGSGGPAYNGM 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Etf-QO	NP_001246231.1	NADB_Rossmann	44..>206	CDD:304358	110/161 (68%)
		FixC	56..516	CDD:223717	306/463 (66%)
		ETF_QO	499..602	CDD:282972	87/102 (85%)
etfdh	NP_001004598.1	FixC	67..529	CDD:223717	306/463 (66%)
		NADB_Rossmann	73..>199	CDD:304358	85/125 (68%)
		ETF_QO	512..615	CDD:282972	87/102 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594609
Domainoid	1	1.000	520	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	841	1.000	Inparanoid score	I424
OMA	1	1.010	-	-		QHG54178
OrthoDB	1	1.010	-	-		D180808at33208
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto40119
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800