DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FMRFa and RBM12B

DIOPT Version :9

Sequence 1:	NP_523669.2	Gene:	FMRFa / 36030	FlyBaseID:	FBgn0000715	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001364889.1	Gene:	RBM12B / 389677	HGNCID:	32310	Length:	1001	Species:	Homo sapiens

Alignment Length:	371	Identity:	97/371 - (26%)
Similarity:	132/371 - (35%)	Gaps:	137/371 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PPQDNDLVDALLGNDQTERAELEFRHPISVIGIDYSKNAVVLHFQKHGRKPRYKYD---PELEAK 103
            ||:|                  :||||                .::..|:| .:.|   |..|..
Human   606 PPED------------------DFRHP----------------REEDWRRP-LEEDWRRPLEEDF 635

  Fly   104 RRSVQDNFMH-----FGKRQAEQL----------PPEGSYAESDE------LEGMAKRAAMDRYG 147
            |||..::|..     |.:...|.|          |||..:....|      |:|..:|...|.:.
Human   636 RRSPTEDFRQLPEEDFRQPPEEDLRWLPEEDFRRPPEEDWRRPPEEDFRRPLQGEWRRPPEDDFR 700

  Fly   148 RDPKQDFMRFGRDPKQDFMR-----FGRDPKQDFMR-----FGRDPKQDFMR-----FGRDPKQD 197
            |.|::||.   ..|::||.:     |.|.|::.|.|     |.|.|.:.|.|     |.|.|.:.
Human   701 RPPEEDFR---HSPEEDFRQSPQEHFRRPPQEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEH 762

  Fly   198 FMR-----FGRTPAEDFMR-----FGRTPAEDFMRFGRSDNFMR-------------FGRSPHEE 239
            |.|     |.|.|.|.|.|     |.|.|.|.|.| .|.::|..             |...|.|:
Human   763 FRRPPPEHFRRPPPEHFRRPPQEHFRRPPQEHFRR-SREEDFRHPPDEDFRGPPDEDFRHPPDED 826

  Fly   240 LRSPK---------QDFMRFGR-------------PDNFMRFG---RSAPQD------FVRSGKM 273
            .|||:         :||.:...             ||||...|   ||.|.|      ||..|:.
Human   827 FRSPQEEDFRCPSDEDFRQLPEEDLREAPEEDPRLPDNFRPPGEDFRSPPDDFRSHRPFVNFGRP 891

  Fly   274 DSNFIRFGKSLKPAAPESK---PVKSNQGNPGERSPVDKAMTELFK 316
            :.....|||....:.||.:   ..|.|.|: |..:|: |.|...||
Human   892 EGGKFDFGKHNMGSFPEGRFMPDPKINCGS-GRVTPI-KIMNLPFK 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FMRFa	NP_523669.2	None
RBM12B	NP_001364889.1	RRM1_RBM12B	2..80	CDD:410139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..147
		RRM2_RBM12B	153..238	CDD:410140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..278
		RRM3_RBM12B	284..363	CDD:409935
		RRM4_RBM12B	400..475	CDD:410142
		PTZ00121	<449..680	CDD:173412	22/108 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..882		69/254 (27%)
		PHA03321	<689..915	CDD:223041	64/229 (28%)
		RRM5_RBM12B	925..1001	CDD:410144	5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910