Protein Alignment IL16 and Patj

DIOPT Version :9

• Sequence 1: NP_001339615.1
• Gene: IL16 / 3603
• HGNCID: 5980
• Length: 1382
• Species: Homo sapiens
• Sequence 2: NP_477342.1
• Gene: Patj / 44100
• FlyBaseID: FBgn0067864
• Length: 871
• Species: Drosophila melanogaster
• Alignment Length: 1141
• Identity: 215/1141 - (18%)
• Similarity: 359/1141 - (31%)
• Gaps: 450/1141 - (39%)

Human   224 RKSLSQQLDCPAG--KAAGTSRPTRSLSTAQLVQPSGG-----LQASVISNI--VLMKGQAKGLG 279
            ::|.|.....|..  |:.|.....|..|     |.|.|     |.|:..:.|  :.:.....|||
  Fly   101 QRSSSHSHSAPGSPDKSGGVGEEPRPQS-----QNSKGAGVADLYATDYAQIQAIELVNDGTGLG 160

Human   280 FSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA--- 341
            |.|:|.::|     |:.||||..||.|..||||:.||.||::...::..:..:......:|:
  Fly   161 FGIIGARNS-----GVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSGTH 220

Human   342 --------------------KKGLLTLTVRTRLTAPPS-----LCSHLSPPLC--RSLSSSTCIT 379
                                :.|  |..|.||:...|:     |.|...|.:.  .|.:|:...|
  Fly   221 VRLVVARPVEQSVPTPQYALEPG--TAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTT 283

Human   380 KDSSSFALESPSAPISTAKPNYRI----------MVEVSLQKEAGVGLGIGLCSVPYFQC----I 430
            .:...|.....::.:  ..||..:          .::|.|:|:|. ||||   ::..:.|    :
  Fly   284 TEDDRFVYRGETSML--IDPNIDLEELLALPETEKLQVELKKDAN-GLGI---TIAGYVCEKEEL 342

Human   431 SGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 495
            |||||.::||||.|.|.||:|..|.|:|:....:      :.|               |.|
  Fly   343 SGIFVKSVSPGSAADLSGRIRVNDRIIEVDGQSL------QGY---------------SNH---- 382

Human   496 VSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIR 560
                       ||||..|  |.....:|    |||....|             |...:.|:.:
  Fly   383 -----------QAVELLK--KSGQVVNL----RLERYLRG-------------PKFEQLQQAI-- 415

Human   561 SSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPLPESRD 625
             :::....|.:| |:|.......|.:....:|.:||..:.||          |.:|:.|.||:..
  Fly   416 -AANDKLPSSAP-GTPSRAPMPTPVATTSSATTTPSRSITRE----------LEEEALPAPEAFM 468

Human   626 SHPPLRLKKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEAREL 690
            :.||     |...:....:||         |.:.    |.|....:|...|....||      |:
  Fly   469 TTPP-----SVTTMTTTTLSS---------FGAG----KQLVAVRDSLDGSTKIIPT------EV 509

Human   691 LPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDY 755
            :||       |.::.:.::|.                        :|              |..|
  Fly   510 VPL-------ADKTEAKNSGV------------------------IT--------------RHKY 529

Human   756 SFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPK 820
            ..|                                                            |:
  Fly   530 YTD------------------------------------------------------------PE 534

Human   821 VYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASS 885
            :...|::..::|         |                               ::.:||.:..
  Fly   535 LSDDAETEIIRK---------W-------------------------------QKIVGSDVEV-- 557

Human   886 SSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQ 950
                |..:|..|...|                        ||...||......||..       :
  Fly   558 ----IVAQIKKFAVGG------------------------LGISLEGTVDVEGGREV-------R 587

Human   951 PEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRA 1015
            |...:.|                          .||.||..:..:|.:..|
  Fly   588 PHHYIRS--------------------------ILPDGPVGVNGVLRSGDE-------------- 612

Human  1016 RSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGAS--PTSS 1078
                          ||:....:|..::.....|::|.   ||..:   :..|.....:|  |.|.
  Fly   613 --------------LLEVNGERLLGMNHLEVVAILKE---LPLDV---RMVCGRNRNSSLLPFSD 657

Human  1079 SNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDD-GDHSSLQSGQSVISLLSSEELK 1142
            ......:|              |...|...|:.|.:||.|.. ....|:..|.||.:..:|
  Fly   658 DTLKKLSN--------------NFENLLPATDRLVKAKSDGSLATAGSVADGDSVAAAAAS---- 704

Human  1143 KLIEEVKVLDEATLKQLDGIHV-----TILHKEEG-AGLGFSL---AGGADLENKVITVHRVFPN 1198
                 ...|...:|:.|.|:.:     .|:...:| .|||||:   ....|..:.:|.:..:.|.
  Fly   705 -----FSKLKSRSLEPLTGLAMWSSQPQIIELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPG 764

Human  1199 GLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDS 1263
            |:|..:|.:..|:.:|.:|..:|:..:...|:..|:.|.:.     |.|....:.:|..::|..:
  Fly   765 GVAQLDGRLIPGDRLLFVNSINLENASLDQAVQALKGASKG-----VVRIGVAKPLPMTDNSLKA 824

Human  1264 AASASAASDVSVES--TEATVCTVTLEKM--SAGLG 1295
            .::||..|:.::::  :...:.||....|  ||.:|
  Fly   825 CSNASTTSEETLDAQPSPPALPTVAPPAMPPSASMG 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL16	NP_001339615.1	PDZ_signaling	268..351	CDD:238492	27/107 (25%)
		PDZ_signaling	406..488	CDD:238492	27/85 (32%)
		COG1615	<911..1006	CDD:332639	14/94 (15%)
		PDZ_signaling	1162..1239	CDD:238492	20/85 (24%)
		PDZ	1284..1370	CDD:214570	6/14 (43%)
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	24/76 (32%)
		PDZ_signaling	318..400	CDD:238492	37/127 (29%)
		PDZ_signaling	557..643	CDD:238492	25/182 (14%)
		PDZ_signaling	726..807	CDD:238492	20/85 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960