Protein Alignment IL16 and CG15803

DIOPT Version :9

• Sequence 1: NP_001339615.1
• Gene: IL16 / 3603
• HGNCID: 5980
• Length: 1382
• Species: Homo sapiens
• Sequence 2: NP_001287388.1
• Gene: CG15803 / 42206
• FlyBaseID: FBgn0038606
• Length: 880
• Species: Drosophila melanogaster
• Alignment Length: 1098
• Identity: 217/1098 - (19%)
• Similarity: 352/1098 - (32%)
• Gaps: 368/1098 - (33%)

Human   414 GVGLG---IGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTI 475
            |.|||   :|..|       :|:.:..|:||.||..||||:.||.:::|.:..:...:..:|.|:
  Fly    19 GNGLGFILVGGRS-------TGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATV 76

Human   476 LSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLE 540
            |.... ..|.:||:|..:|...:.|.....|..:. ||...:..:                  |.
  Fly    77 LRQTG-AQVRLIVARPVEPTAIDYQTLACQAPIIP-TKLLSDPEE------------------LS 121

Human   541 KEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAE----------KPSSDVDISTHSP 595
            :...:|   |......|...:::.::..|||.|...|.|..:          .|:...::|...|
  Fly   122 RHLFQN---PSFATAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEP 183

Human   596 SLPLAREPVVLSIASSRLPQES-----------PPLP----------ESRDSHPPLRLKKS---F 636
                  :|   |.|..:|.|.|           ||:|          .:....|..||...   |
  Fly   184 ------QP---SAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPF 239

Human   637 EILVRKPMSSKPKPPPRKYFKS-DSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDT 700
            .||         .||||...:. ..:.|....:.:|.     |.........|:    ||..||
  Fly   240 SIL---------SPPPRPALQMLPLETQWRCVQDQNR-----HIETVIADSKRK----LLANED- 285

Human   701 AGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPW 765
             |.|.|||.               .|.|.....||.|:|..::   |.:..   |....|.....
  Fly   286 -GGSASASG---------------SGSPDSYMDSPETETYVVE---LHKNV---YGLGITVAGYV 328

Human   766 VRISDC----IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSAD 826
            ....|.    :|::.....:|..|.  :|.|..:...:|
  Fly   329 CEEEDLSGIFVKSIIEGSAAETSGQ--IQINDRIVAVDG-------------------------- 365

Human   827 SSTVKKGPPVAPKPAWFRQSLKGLRN-------RASD----------PRGLPDPALSTQPAPASR 874
                              :||.|:.|       |.:|          .||            ...
  Fly   366 ------------------RSLSGVTNHQAVELLRNTDIVVHLTLERFLRG------------RKY 400

Human   875 EHLG---SHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLS----LQPSSGEAAKPLGKHEEG 932
            |||.   :.|:.:|:.|.: .|....:....|||...|:..::    |.|.|.:|
  Fly   401 EHLQVALTEIKGTSAPSGL-DRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDA---------- 454

Human   933 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLS 997
                               :.:.:.|..|. :|...|:|.:               .|..:.|.|
  Fly   455 -------------------DSIATEGDEAV-DAEYVGISGA---------------EDEFIELPS 484

Human   998 TQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISC 1062
            ....||.           .|..|.||........|:    :..||..|.....:||:.
  Fly   485 RDTVESN-----------MSHVLDRSDHSGGLTKDQ----VPRISPIVPLTNGRSLIL------- 527

Human  1063 AQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQ 1127
                      |..:.:..::..|....||:....|.......:::    |.:.|.|.|.| ..|.
  Fly   528 ----------ADDSGNDTDEQCAEPETETAQARKGSKPETERVKD----LGDTKTDTDPD-PDLD 577

Human  1128 SGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT- 1191
            .||....                .:||.:|.......::  :.....||.||.|..|:|..:..
  Fly   578 PGQMPTP----------------TNEAPVKAASPTAASL--RVAWKSLGISLEGTVDVECGIEKR 624

Human  1192 ----VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQ---------AREPRQAV 1243
                :..:..:|...::|.::.|:|:|.:|...|:|..|.:.:.||::         ||......
  Fly   625 PHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPS 689

Human  1244 IVTRKLTPEA------MPDLNSS----------------------TDSAASA--------SAASD 1272
            ::.....|||      :|..:.|                      ||:.|:|        ..|..
  Fly   690 VINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARS 754

Human  1273 VSVESTEATV---CTVT---LEKMSAGLGFSLEGGKGSLHGD-KPLTINRIFKGAASEQSETVQP 1330
            .|:|:.....   |.||   :||...|.|||:...:..|..: ..:.|..:.:|.|:|.:..:.|
  Fly   755 KSLENVSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYP 819

Human  1331 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR------KSLQSKETTAAGDS 1382
            ||.::.:|...:|||...||.:|:||:|.|...:.|.|      .:..|...:..|||
  Fly   820 GDRLMSVGDRLLQGLELDEAVSILKAMPPGLTRLGICRPLSASDSNSNSNIASPLGDS 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL16	NP_001339615.1	PDZ_signaling	268..351	CDD:238492
		PDZ_signaling	406..488	CDD:238492	23/76 (30%)
		COG1615	<911..1006	CDD:332639	14/98 (14%)
		PDZ_signaling	1162..1239	CDD:238492	20/90 (22%)
		PDZ	1284..1370	CDD:214570	29/95 (31%)
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	24/77 (31%)
		PDZ	307..393	CDD:214570	17/137 (12%)
		PDZ_signaling	605..680	CDD:238492	18/74 (24%)
		PDZ	773..858	CDD:214570	26/84 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960