DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IL16 and bbg

DIOPT Version :9

Sequence 1:NP_001339615.1 Gene:IL16 / 3603 HGNCID:5980 Length:1382 Species:Homo sapiens
Sequence 2:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster


Alignment Length:2015 Identity:383/2015 - (19%)
Similarity:622/2015 - (30%) Gaps:827/2015 - (41%)


- Green bases have known domain annotations that are detailed below.


Human     9 QNSSQLPNLR---------THEVAAKPCPVATRQPRARDQERKKGSFTSSLRMESHSRAGKSRKS 64
            :.|.:||.:.         |.:..|.....|||.. .||:      .|::...|..|.:..|.||
  Fly   788 EESKKLPKMEVNAGGLAQLTDDKIADHDASATRAD-TRDE------VTTNQTQEISSSSSSSVKS 845

Human    65 AKFRSISRSLMLCNAKTSDDGSS--------PDEKYP-DPFEIS---LAQGKEGIFHSSVQLADT 117
            .|..:.:|   :...|||...||        ||..:. .|:|..   |::....|......|::.
  Fly   846 QKTTTTTR---VTTTKTSSSSSSSSCSSTVIPDVAFKLQPYEERDDILSEPITTIHEERRVLSEQ 907

Human   118 SEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEAQSSNFLFPKAC 182
            .....|...| ||..| .||..:.|.:..:.|   |.|.||..:..:...:.:.|..        
  Fly   908 KTLSESRTRD-ALTGE-EQLVTSANSKSSSAR---FKKISSNDNLLDLGDEQDMQEQ-------- 959

Human   183 HQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPAGKAAGTSRPTRS 247
                                 |:|            :..:...||.::|:||        :..:|
  Fly   960 ---------------------PLT------------ATITQESSLRERLECP--------QDNQS 983

Human   248 LSTAQLVQPSGGLQASVISNIVLMKGQAKGL----------------GFSIVGGKDSIYGPIGIY 296
            :....|.....|.|.|          :.:||                |..::.||       |.:
  Fly   984 IDRGTLTLSERGKQLS----------EKEGLTTYTECETSEKESYLEGQQVLNGK-------GGF 1031

Human   297 VK------------------TIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ----------- 332
            |.                  ||...|......:|::..||....|..:...|.:           
  Fly  1032 VSQDENSDQPTYEREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGAKLLKKTDEERRLEQEAQKL 1096

Human   333 -DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL--------- 387
             ::.||.|:..:.|..|.                            :..|...|.|         
  Fly  1097 IESYQKVKKEAEKLYKLE----------------------------LADDDQGFDLSAFEQAEEE 1133

Human   388 ESP--SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRL 450
            :.|  |..|...|.:..:.|::.:::|                        ..:|..|.   |.:
  Fly  1134 DKPEVSEEIKEVKDSQPVKVDIQIEEE------------------------VKTPNQVI---GEV 1171

Human   451 RCGD------EIVEISDSPV-------HCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 502
            :..|      |.|::|...:       |..| .|.:......:...:.|:   ..:.:|:.|.|:
  Fly  1172 KVEDVNKEIKETVQVSQQEIKKEVKVSHQET-KETFKSEEKDESNELKIV---KEEVKVTHQDLR 1232

Human   503 EAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLE----KEREKN-SAPPHRRAQKVMIRS- 561
            |.: |.:|..|...:..:...|..|...::.|.:.|.|    ||..|| ||.|.....||.|.| 
  Fly  1233 EQI-QEIEAVKVVHKEVKVIKESAKVTTTTSHKQATKEVIISKEDHKNDSALPAVSTTKVEIISP 1296

Human   562 --SSDSSY------------MSGSPGGSPGSGSAEKPSSDVDISTHSPSLPL------AREPVVL 606
              ..|..|            :..:|...|      ||.....:.|:.|.:|:      :..|.|.
  Fly  1297 PLEDDLGYVLHKHIIFPQEKVKTAPTPLP------KPKPKPPVPTNKPKMPVNLTKPKSAPPPVP 1355

Human   607 SIASSRLPQESPPLPESR-----DSHPPLRLKKSFEILVRKPMSSKPK----------------- 649
            |..|........|.|..|     .:.||..|::....:.::....||:                 
  Fly  1356 SKRSELSGSGGKPTPTQRRGSLETAQPPKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNS 1420

Human   650 -------------PPPRKYFKS-----DSDPQKSLEEREN-----SSCSSGHTPPTCG------- 684
                         ||....|:|     |.:.:|.|.:..|     ||.||..||.|..       
  Fly  1421 KQATVETTPVVEMPPDELQFESHQLPDDGEKEKDLHQESNDLLSGSSSSSVTTPITTPILVSATS 1485

Human   685 -----QEAREL---LPLL---------------------LPQEDTAGRSP--------------- 705
                 |...|:   :|::                     |..|.|....|               
  Fly  1486 SMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAAYDDGMHLEAEGTKDVRPVQEVTTLTLDREHES 1550

Human   706 ------------------SASAGCPGPGIGPQT--KSSTEGEPGWRRASPVTQTSPIKHPLLKRQ 750
                              :||:..|...:...:  |:|||.    ....|.....|.|..||  .
  Fly  1551 DLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTSTEA----ATTKPAAPQIPGKMELL--S 1609

Human   751 ARMDYSFDTTAEDPWVRISDCIKNL-----------------------FSPIMSE---NHGHMPL 789
            :....:..||.....:..:...|.|                       |.|..||   .|.| ||
  Fly  1610 SNTGTTTTTTTATHHLHQATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSH-PL 1673

Human   790 QPNASLNEEEGTQGHPDGTPPKLDTANGTP-----KVYKSADSSTVKKGPPVA------------ 837
            :....|:.|....|..:.:.|.| ...|.|     |||:......|:..|.:.            
  Fly  1674 KVTTELSYEIQKGGKDESSAPPL-PKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTP 1737

Human   838 PKPAWFR---QSLKGLRNRA------SDPRGLPDPALSTQPAPAS--REHLGSHIR------ASS 885
            .||:.:|   :|.|.:|::.      ::...:| ||.:|.|..:|  |:.|.....      :||
  Fly  1738 RKPSDWRKDEKSEKSVRDKIAMFSSNNELDAIP-PAPATAPISSSFTRKPLNRSSENLLDSCSSS 1801

Human   886 SSSSIRQRISSFETFGSSQLPDKGAQRL-------------SLQPSSGEAAKPL----GKHEEG- 932
            |:.|::.|..|.|.....|...:.|::|             :..|:...|:.|.    |.:..| 
  Fly  1802 SAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPTPSYASLPRRSHGGSYSSGV 1866

Human   933 ----RFSGLLG----RGAAPT----------------LVPQQPEQV--------LSSGSPAAS-- 963
                .|||..|    |.||.|                ::|::|:.:        :.|...|||  
  Fly  1867 ERRISFSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGE 1931

Human   964 EARDPGVSE-------------------------------------SPPPGR---------QPNQ 982
            ::.|.|:.|                                     |.||.:         ||..
  Fly  1932 DSTDSGLGESHRSTVNRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRS 1996

Human   983 KTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCE--TKLLDEKTSKLYSISSQV 1045
            ..:||.|.||.:...|.:..|....:..|.::   |.|||:.|.|  |.:....||.|.|.||..
  Fly  1997 MMIPPPPPPLDQESDTDSVFSHTARVATPPEK---FALTRTLSSETNTSIASSNTSTLTSGSSAG 2058

Human  1046 SSAVMKSLLCLP----------------------------SSISC-------------------- 1062
            |.|...||...|                            :|..|                    
  Fly  2059 SQASCSSLGSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEAC 2123

Human  1063 --------------------------------------------------AQTPC---------- 1067
                                                              :.||.          
  Fly  2124 SLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDEE 2188

Human  1068 ----------------------------IPKEGASP-----TSSSNE--DSAANGSAET------ 1091
                                        :|.....|     |:...|  :.:|...|:|      
  Fly  2189 RKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPV 2253

Human  1092 -------------SALDTGFSLNLSELREYTEGLTEAKE--DDDGDHSSLQSGQSVISLLSSEEL 1141
                         |:||: .:.:.|.:...|:.::..:|  .:.|..|||.|.|   ||::::::
  Fly  2254 IHKVTQKPHHERFSSLDS-LASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQ---SLITAQDV 2314

Human  1142 KKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 1206
            ::::||.    :..||..:...:.:..:...:.:|.:||||:|.|.|.||:|::..|..|:::|.
  Fly  2315 QQIVEEA----DPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGR 2375

Human  1207 IQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR--KLTPEAMPDLNSSTDSAAS--- 1266
            ::||:.:|::||.|::|.||.:::::|:..| |...::|||  .|..:|:....||..|.:|   
  Fly  2376 LKKGDRILAVNGMSMRGLTHRESISVLKTPR-PEVVLVVTRSESLVVKALTKKRSSLGSLSSLNE 2439

Human  1267 ---------------ASAASDVSV-------------------------------ESTEATVC-- 1283
                           ||.:.|:.:                               |..|||:.  
  Fly  2440 KPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGI 2504

Human  1284 -------------------------------------------------TVTLEKMSAGLGFSLE 1299
                                                             .|.:.|.|.|||||:|
  Fly  2505 RARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIE 2569

Human  1300 GGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTI 1364
            ||..|..|::||.:.::|.|.|::::..|:.|||||.:.|.:...:||.:|||.:|.||.|||.|
  Fly  2570 GGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKI 2634

Human  1365  1364
              Fly  2635  2634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IL16NP_001339615.1 PDZ_signaling 268..351 CDD:238492 20/128 (16%)
PDZ_signaling 406..488 CDD:238492 12/94 (13%)
COG1615 <911..1006 CDD:332639 35/192 (18%)
PDZ_signaling 1162..1239 CDD:238492 25/76 (33%)
PDZ 1284..1370 CDD:214570 37/81 (46%)
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 3/24 (13%)
PDZ_signaling 2331..2413 CDD:238492 26/82 (32%)
PDZ_signaling 2553..2634 CDD:238492 36/80 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 68 1.000 Domainoid score I9725
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11324
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5666
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.130

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