DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1441 and FAR1

DIOPT Version :9

Sequence 1:	NP_610535.1	Gene:	CG1441 / 36029	FlyBaseID:	FBgn0033464	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_011518702.1	Gene:	FAR1 / 84188	HGNCID:	26222	Length:	518	Species:	Homo sapiens

Alignment Length:	516	Identity:	174/516 - (33%)
Similarity:	286/516 - (55%)	Gaps:	45/516 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IAECFKGRSLFITGGTGFLGKVLVEKLLRSCGGLKRIYLLIRPKKGKDPQERIKDIFQNVLFDQV 92
            |.|.::|:::.:||.||||||||:|||||||..:..:|:|:|.|.|:.||||::::....|||::
Human     4 IPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRL 68

  Fly    93 KQMRGEEHILQQVVAIAGDVLSPGLGISEKDLETLRQEVSIVYHCAATVRFDEPLRNAVFMNTRG 157
            :....:  ..::::||..::..|.|.:||:|.|.:....:|::||||||||:|.||:||.:|...
Human    69 RDENPD--FREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIA 131

  Fly   158 TKYMLELALTLKHLDFFAYCSTAYCHLHVKTLYEKPYDPPADPHKVMQACEWLTDDEVATIERKV 222
            |:.::.||..:|:|:.|.:.||||.:.:.|.:.|..|.||.||.|::.:.||:.|..|..|..|:
Human   132 TRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKL 196

  Fly   223 LGAIPNTYAYTKSLAEALVVEKFEELPAVILRPSIVIPIWKEPIPGWTDNINGPTGLLIGAGKGV 287
            :|..||||.|||:|||.:|.::..:|...|:|||||...||||.|||.||.|||:||.|.||||:
Human   197 IGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGI 261

  Fly   288 IRTMYCNSSGYGDFLPVDVAVNGILVASW----------RNITAGTDKTNRVAHMTSSNDIKVSW 342
            :||:..:::...|.:||||.||..|.|:|          |||        .|.:.|:.:.....|
Human   262 LRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRYMRPRNI--------MVYNCTTGSTNPFHW 318

  Fly   343 AEIIELGRWVIE--NKVPLNGVAWYPGGSMKSNYWVHFICMVLFQWMPALFVDALLWILRYPPVL 405
            .|:   ...||.  .:.||......|..::.||:.::...:.:....||...|..|.:....|.:
Human   319 GEV---EYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRM 380

  Fly   406 CRVQNRIYKGFEVFEYYANNVWNFDNSEAVKLRKLMNNKERRTYVIEKIELDLIDYFTNCVLCAR 470
            .:...|::|.....||:.:|.|.::......|...:|.::::|:.|:..:|...:|..|..|..:
Human   381 MKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTK 445

  Fly   471 RLILKESDESIPAARRHMK---------------VMWVV----DKVYKGIWIFGILYMLYR 512
            :.:|.|....:||||:|:.               ::|.:    .::.:.||.| ::.:.|:
Human   446 KYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYF-VVSLCYK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1441	NP_610535.1	PLN02996	24..464	CDD:215538	160/447 (36%)
		FAR-N_SDR_e	35..348	CDD:187547	133/322 (41%)
		Sterile	385..475	CDD:281068	19/89 (21%)
FAR1	XP_011518702.1	PLN02996	2..449	CDD:215538	162/457 (35%)
		FAR-N_SDR_e	11..333	CDD:187547	135/334 (40%)
		Sterile	360..450	CDD:281068	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56516
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860