DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1441 and CG4020

DIOPT Version :9

Sequence 1:	NP_610535.1	Gene:	CG1441 / 36029	FlyBaseID:	FBgn0033464	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	178/499 - (35%)
Similarity:	284/499 - (56%)	Gaps:	27/499 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IAECFKGRSLFITGGTGFLGKVLVEKLLRSCGGLKRIYLLIRPKKGKDPQERIKDIFQNVLFDQV 92
            |.|.|:.:.:|:||.:||:||.|:|||||||..|.|||:|:|||||...:||::..:::.|::::
  Fly     3 IPEAFEDQEIFVTGASGFVGKALIEKLLRSCPKLGRIYVLMRPKKGHTIEERLQLQWESRLYERL 67

  Fly    93 KQMRGEEHILQQVVAIAGDVLSPGLGISEKDLETLRQEVSIVYHCAATVRFDEPLRNAVFMNTRG 157
            :  |.:.:...::|||||||...||||...|||.|| .|:||||.||:||||:.|..|:.:||||
  Fly    68 R--REQPNARSKLVAIAGDVEQLGLGIGSADLERLR-NVNIVYHSAASVRFDDALSTAILLNTRG 129

  Fly   158 TKYMLELALTLKHLDFFAYCSTAYCHLHVKTLYEKPYDPPADPHKVMQACEWLTDDEVA-TIERK 221
            |..:::|||....|..|.:.||.|.:..|..:.|:.|.|.||         |.|..::| |.:.:
  Fly   130 THELVKLALEWPKLKAFVHVSTTYSNPGVLEVEERVYPPLAD---------WRTTIKLAETYDAE 185

  Fly   222 VLGAI--------PNTYAYTKSLAEALVVEKFEELPAVILRPSIVIPIWKEPIPGWTDNINGPTG 278
            :|...        ||||.:||||||.:|.|..:.||..|.|||||:...:||:|||.||.|||||
  Fly   186 ILDIFNLKYGNFQPNTYTFTKSLAEQVVNEYRDRLPIFIFRPSIVVSTIEEPVPGWADNFNGPTG 250

  Fly   279 LLIGAGKGVIRTMYCNSSGYGDFLPVDVAVNGILVASWR----NITAGTDKTNRVAHMTSSNDIK 339
            ||:..|.|::|:..|:.:...||:|.|:....::.:.::    :.:...|....|.:..::|...
  Fly   251 LLVACGVGILRSQNCDPNIVADFVPADIVARTLITSVYKFMGESKSRAKDSDLYVVNCATANISP 315

  Fly   340 VSWAEIIELGRWVIENKVPLNGVAWYPGGSMKSNYWVHFICMVLFQWMPALFVDALLWILRYPPV 404
            ::..|:|::|:..| .|.|.....|.|||.|.:...:||:.......:.|:.||.||.:....|.
  Fly   316 ITMGEVIDIGKTFI-RKNPFEKTLWLPGGGMTTCPVLHFVRFCTMHLLMAIVVDTLLRLYNEKPF 379

  Fly   405 LCRVQNRIYKGFEVFEYYANNVWNFDNSEAVKLRKLMNNKERRTY-VIEKIELDLIDYFTNCVLC 468
            |.::|.||:..|...:.:|...|:|.|.....|..::...|...: .::...::..::|.:.:..
  Fly   380 LMKLQRRIFAAFSALQVFAMTEWHFQNDNFRALHDVVPANEVSNFGFMQHANINYTEFFQHGIRG 444

  Fly   469 ARRLILKESDESIPAARRHMKVMWVVDKVYKGIWIFGILYMLYR 512
            |:..:||||.||..|||..:|:.:|:|.:.:||....:|.:::|
  Fly   445 AKEFLLKESPESSSAARFRVKIFYVLDFLCRGIVYSFLLRLIFR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1441	NP_610535.1	PLN02996	24..464	CDD:215538	161/449 (36%)
		FAR-N_SDR_e	35..348	CDD:187547	129/325 (40%)
		Sterile	385..475	CDD:281068	19/90 (21%)
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	132/333 (40%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924	19/90 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466743
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	11	10.850