DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1441 and Far1

DIOPT Version :9

Sequence 1:	NP_610535.1	Gene:	CG1441 / 36029	FlyBaseID:	FBgn0033464	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001011933.1	Gene:	Far1 / 293173	RGDID:	1306647	Length:	515	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	182/519 - (35%)
Similarity:	290/519 - (55%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IAECFKGRSLFITGGTGFLGKVLVEKLLRSCGGLKRIYLLIRPKKGKDPQERIKDIFQNVLFDQV 92
            |.|.::|:::.:||.||||||||:|||||||..:..:|:|:|.|.|:.||||:::|....|||::
  Rat     4 IPEYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEILSGKLFDRL 68

  Fly    93 KQMRGEEHILQQVVAIAGDVLSPGLGISEKDLETLRQEVSIVYHCAATVRFDEPLRNAVFMNTRG 157
            :....:  ..|:::||..::..|.|.:||:|.|.:....::::||||||||:|.||:||.:|...
  Rat    69 RDENPD--FRQKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIA 131

  Fly   158 TKYMLELALTLKHLDFFAYCSTAYCHLHVKTLYEKPYDPPADPHKVMQACEWLTDDEVATIERKV 222
            |:.::.||..:|:|:.|.:.||||.:.:.|.:.|..|.||.||.|::.:.||:.|..|..|..|:
  Rat   132 TRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKL 196

  Fly   223 LGAIPNTYAYTKSLAEALVVEKFEELPAVILRPSIVIPIWKEPIPGWTDNINGPTGLLIGAGKGV 287
            :|..||||.|||:|||.:|.::..:|...|:|||||...||||.|||.||.|||:||.|.||||:
  Rat   197 IGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGI 261

  Fly   288 IRTMYCNSSGYGDFLPVDVAVNGILVASW-------RNITAGTDKTNRVAHMTSSNDIKVSWAEI 345
            :|||..:::...|.:||||.||..|.|:|       |||        .|.:.|:.:.....|.|:
  Rat   262 LRTMRASNNALADLVPVDVVVNTSLAAAWYSGVNRPRNI--------MVYNCTTGSTNPFHWGEV 318

  Fly   346 IELGRWVIENKVPLNGVAWYPGGSMKSNYWVHFICMVLFQW------MPALFVDALLWILRYPPV 404
            .:......:.. |||.|..:|.....||.      ::|..|      :|||.:|..|.:....|.
  Rat   319 GDYLNHSFKTN-PLNQVFRHPYVKFYSNN------LMLHYWKGVKHTVPALLLDLALRLTGQKPW 376

  Fly   405 LCRVQNRIYKGFEVFEYYANN--VWNFDNSEAVKLRKLMNNKERRTYVIEKIELDLIDYFTNCVL 467
            :.:...|::|.....||:.:|  |||.||..  .|...:|.::::|:.|:..:|...:|..|..:
  Rat   377 MMKTITRLHKAMVFLEYFTSNSWVWNTDNVN--MLMNQLNPEDKKTFNIDVRQLHWAEYIENYCM 439

  Fly   468 CARRLILKESDESIPAARRHMK---------------VMWVV----DKVYKGIWIFGILYMLYR 512
            ..::.:|.|....:||||:|:.               ::|.:    .::.:.||.| ::.:.|:
  Rat   440 GTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYF-VVSLCYK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1441	NP_610535.1	PLN02996	24..464	CDD:215538	169/450 (38%)
		FAR-N_SDR_e	35..348	CDD:187547	135/319 (42%)
		Sterile	385..475	CDD:281068	24/97 (25%)
Far1	NP_001011933.1	PLN02996	2..446	CDD:215538	170/460 (37%)
		FAR-N_SDR_e	11..330	CDD:187547	135/329 (41%)
		Sterile	371..447	CDD:281068	18/77 (23%)
		Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000250\|UniProtKB:Q8WVX9	451..507		10/53 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56516
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860