DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1513 and Osbpl5

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_077251.1	Gene:	Osbpl5 / 79196	MGIID:	1930265	Length:	898	Species:	Mus musculus

Alignment Length:	685	Identity:	193/685 - (28%)
Similarity:	295/685 - (43%)	Gaps:	149/685 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 RVSEADA-------YLQLMIEQTNLLDKRIAELTDP-----AEQSKCKALQDNANAMLDHIKHSI 214
            |||:.||       |.|   |:.....:..:.||||     |:..|.:....:...:...:|..:
Mouse   116 RVSKKDALKAQKENYRQ---EKKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGV 177

  Fly   215 VSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLK--------VPLEGQVIG- 270
            :.             ||..|    ........|.:..|..::....|        .||:..|..
Mouse   178 LL-------------IYKTP----KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAV 225

  Fly   271 ---KGELVDDEEDSATENATTAPLGLIVPATSY------SSSEGEEDFYDAYDDPFTSIGSSPIG 326
               |||.|         .:.|.||     .:||      |.|:| ..:.||.:
Mouse   226 KGPKGESV---------GSITQPL-----PSSYLIFRAASESDG-RCWLDALE------------ 263

  Fly   327 CATRGFAETTSPTHEKAPDGFANAEPVAVGDSV----APQTLPEID------------------- 368
            .|.|..:.....|.::..||...:.|.|...|:    ...|:|:.|
Mouse   264 LALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLYGLPTSATIPDQDLFPLNGSALENDAFSDKSE 328

  Fly   369 -ESVADADTSIKT-ARTAVSSRSASYDN------GIDYDALYEEE----EET---DLSMEAHGSM 418
             |:..|:|...:. :|....|.|...|:      |..|....:||    :||   :...|.:.|:
Mouse   329 RENAEDSDAETQDHSRKTNESGSDLLDSPGGPWRGTTYVEQVQEELGELDETSQVETVSEENKSL 393

  Fly   419 ITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRDRIVQVCRWYMS 483
            :..||.|::.||||::||||||:||.||.|...:||:.|.||..:.:..|||..|:..|.|||:|
Mouse   394 MWVLLRQLRPGMDLSRVVLPTFVLEPRSFLGKLSDYYYHGDLLSRAAAEDDPYCRMKLVLRWYLS 458

  Fly   484 AYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQLTF-LAEQVSHHPP 547
            .::  :|....||||||||||.|:|.|..|                 :.:..|| :|||||||||
Mouse   459 GFY--KKPKGIKKPYNPILGETFRCRWLHP-----------------QTNSHTFYIAEQVSHHPP 504

  Fly   548 ISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVTFPNGYGRSIL--T 610
            :||||..:.......:..:..||||.|.|:.....|:..:|.::|.|||.:|.|..:.|.||  |
Mouse   505 VSAFYVSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGILYGT 569

  Fly   611 VPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKR--NRVSAEVYAPSEKKPFVSITGEWSGLME 673
            :. :||||.|.|:|.::...|.::|..|||:|...  |::|.::.  |.::....:||.|...:.
Mouse   570 MT-MELGGKVNIECEKNNLQAELDFKLKPFFGSSANINQISGKIM--SGEEVLARLTGHWDRDVF 631

  Fly   674 AKWHDKNKTEVF----VDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAGLKFNDIERATTAKFV 734
            .|......||:|    .:|.|..: |:....:.||.|.||.|:|:.||..::..|..:||..|.|
Mouse   632 IKEESSGGTELFWTPSEEVRRQRL-KRHTVLLEEQSELESERLWQHVTRAIREGDQHKATQEKSV 695

  Fly   735 VEQQQRDQAKVRKEYDLAWEHKHF--KPVGDNWIY 767
            :|:.||.:|:..::....|:.:.|  .|:...|.|
Mouse   696 LEEAQRQRAREHQQSLTPWKPQLFLLDPLTQEWRY 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444
		PH	25..118	CDD:278594
		Oxysterol_BP	421..767	CDD:279564	128/356 (36%)
Osbpl5	NP_077251.1	PH_OPR5_ORP8	144..272	CDD:270103	32/171 (19%)
		PH	151..267	CDD:278594	27/159 (17%)
		Oxysterol_BP	397..730	CDD:279564	128/355 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850