DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and osbpl9

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001071273.1	Gene:	osbpl9 / 777767	ZFINID:	ZDB-GENE-061110-103	Length:	733	Species:	Danio rerio

Alignment Length:	799	Identity:	377/799 - (47%)
Similarity:	511/799 - (63%)	Gaps:	119/799 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDALIGIDDQEDNTFT 88
            :||.||||||||||||||:||||.||||||||||||||::|.|||||||:.|:|||||::|:|||
Zfish     5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFT 69

  Fly    89 ITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRRP 153
            ||||.||||||||..:|||:|:..||.||.||..:.   ::::.|.                  |
Zfish    70 ITVDQKTFHFQARDADEREKWIHALEGTILRHTLQQ---EAETGFV------------------P 113

  Fly   154 NHLELVARRVSEADAYLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKHSIVSLQ 218
            : ::...::::|||||||::|:|..|.|::|.:..:...:.|.:.|:|....|::.|||.||.||
Zfish   114 S-VQDFDKKLAEADAYLQILIDQLKLFDEKIKDCKEDESRRKIENLKDTTCNMVESIKHCIVLLQ 177

  Fly   219 IAKNMA-------------HPINGIYNGPPATASTSSST----------------------SGVA 248
            |||:.:             :|::|::...|..|:..|::                      |.:.
Zfish   178 IAKDQSNEQQHANGLISTINPVDGVFQPTPLNAAVVSASAMPTQTTLPTDGAQVCKAEQRPSSLP 242

  Fly   249 MGSCNNVQAGGLKVPLEGQVIGKGELVDDEEDSATENATTAPLGLIVPA-----TSYSSSEGEED 308
            :|....|. |.|:.|..... |.|       .|...::.|:|..:.|||     .|||||  |::
Zfish   243 VGPVVTVM-GSLQTPTPNST-GSG-------PSGPSSSVTSPSHMNVPAHTVPDFSYSSS--EDE 296

  Fly   309 FYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEKAPDGFANAEPVAVGDSVAPQTLPEIDESVAD 373
            ||||  |.|              :..:|||.|...|   :.:..|...||.|.:. |:.:||:
Zfish   297 FYDA--DEF--------------YQNSTSPKHCIDP---SRSSAVNNEDSTALKR-PDTNESI-- 339

  Fly   374 ADTSIKTARTAVSSRSASYDNG-IDYDALYEEEEETD----LSMEAHGSMITHLLSQVKIGMDLT 433
                           ::|..|| .|.|.....:|:.|    .|:|.|.|:|.||||||::|||||
Zfish   340 ---------------NSSMSNGTTDADQFDSHDEKDDDGEGESVEEHKSVIMHLLSQVRLGMDLT 389

  Fly   434 KVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRDRIVQVCRWYMSAYHAGRKSAVAKKPY 498
            ||||||||||||||||||||:|||||||:.|::..|||||:|||.:||:||:|||||.:||||||
Zfish   390 KVVLPTFILERRSLLEMYADFFAHPDLFVSIAEQQDPRDRMVQVVKWYLSAFHAGRKGSVAKKPY 454

  Fly   499 NPILGEVFQCHWDIPGISQD--AQE-VRDGPVPWCRRDQLTFLAEQVSHHPPISAFYAEHYNKKI 560
            ||||||||.||||:|..::|  |.| |.||||||..::.::|:||||||||||||||||.::|||
Zfish   455 NPILGEVFFCHWDLPSETEDPAASECVSDGPVPWSSKNSVSFVAEQVSHHPPISAFYAECFSKKI 519

  Fly   561 TFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVTFPNGYGRSILTVPWIELGGSVEIKCP 625
            .|.||:||||||||:||||||||:|.|:.::..|.||:.||||||||||||||:||||...|.|.
Zfish   520 QFNAHIWTKSKFLGMSIGVHNIGQGCVSCLEYDEHYILNFPNGYGRSILTVPWVELGGECNISCS 584

  Fly   626 QSGYYANVEFLTKPFYGGKRNRVSAEVYAPSEKKPFVSITGEWSGLMEAKWHDKNKTEVFVDVNR 690
            :|||.||:.|.||||||||::|::||::||::||.:.||.|||:|:|.:|. ...:..||:|..:
Zfish   585 KSGYSANIVFHTKPFYGGKKHRITAEIFAPNDKKSYCSIEGEWNGVMYSKL-ATGENAVFIDTKK 648

  Fly   691 IPIFKKQVRPIVEQDEYESRRVWKEVTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEH 755
            :.:.||:||.:.:|.|||||.:||:||..||..||:.||.||..:|::||.:|:.|||.::.||.
Zfish   649 LGLIKKKVRKLEDQLEYESRCLWKDVTMNLKLKDIDAATEAKHRLEEKQRAEARERKEKEMQWET 713

  Fly   756 KHFKPVGDNWIYAKPLSQR 774
            :.|...|:.|:|.|||.:|
Zfish   714 RLFHEDGECWVYDKPLLKR 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	74/100 (74%)
		PH	25..118	CDD:278594	71/92 (77%)
		Oxysterol_BP	421..767	CDD:279564	215/348 (62%)
osbpl9	NP_001071273.1	PH	4..98	CDD:278594	70/92 (76%)
		PH_ORP9	5..106	CDD:241444	74/103 (72%)
		PHA02664	<272..370	CDD:177447	37/136 (27%)
		Oxysterol_BP	377..725	CDD:279564	215/348 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578146
Domainoid	1	1.000	460	1.000	Domainoid score	I464
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69380
Inparanoid	1	1.050	677	1.000	Inparanoid score	I696
OMA	1	1.010	-	-		QHG47954
OrthoDB	1	1.010	-	-		D289732at33208
OrthoFinder	1	1.000	-	-		FOG0001312
OrthoInspector	1	1.000	-	-		oto39125
orthoMCL	1	0.900	-	-		OOG6_106581
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	1	1.000	-	-		X4688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800