DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and CG42668

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001189250.2	Gene:	CG42668 / 42412	FlyBaseID:	FBgn0261550	Length:	990	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	240/525 - (45%)	Gaps:	85/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 DSATENA-TTAPLGLIVPA---TSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTH 340
            :|:|..| |::.:|..:|.   |.:|.::.|:.|.| :|....|...:|....:...:|:.|...
  Fly   365 NSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFND-HDLDADSQNEAPNAVMSGLESESESDPA 428

  Fly   341 EKAPDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYEEE 405
            |.|.|...:.:  .|..|..|.|..|..|                        .|...:.|.||.
  Fly   429 EPAQDDVVDQQ--CVETSYVPFTEEEFGE------------------------QGEQVEELAEEN 467

  Fly   406 EETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDP 470
            :          |:|..::.||:.||||:||||||||||.||.|:..:|.:.|.||..|....||.
  Fly   468 K----------SLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDA 522

  Fly   471 RDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQL 535
            ..|:..|.:||:|:::  :|....||||||||||.|:|:|..|..|:
  Fly   523 FTRMKLVVQWYLSSFY--KKPKGLKKPYNPILGERFRCYWQHPSGSR------------------ 567

  Fly   536 TF-LAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVT 599
            || :|||||||||:||||..:.....:....:..||||.|.|......|...:||:.|.|.|..|
  Fly   568 TFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTAT 632

  Fly   600 FPNGYGRSIL--TVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGG--KRNRVSAEVYAPSEKKP 660
            .|..:.:.||  |:. :||||.:.|:|..:||...:||..|||.||  ..|.|..::  ...|:.
  Fly   633 TPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKI--KLGKET 694

  Fly   661 FVSITGEWSGLMEAKWHDKNKTEVFVDVNRIPIFKKQVR---PIVEQDEYESRRVWKEVTAGLKF 722
            ..:|.|.|......|.....:..|...|:.....|:..|   |:..|:..||:|:|:.|:..:..
  Fly   695 LATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIAN 759

  Fly   723 NDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFKPVGD-----NWIY----AKPLSQRMYLQ 778
            .|...||..|.|:|::||..||.|    |:.:..|...:.:     .|:|    .:|...|..::
  Fly   760 EDQVAATEEKTVLEERQRADAKER----LSSDSVHMPDLFELDSYGQWLYKYADLRPWDSRNDVR 820

  Fly   779 EKEAK 783
            :.|.:
  Fly   821 QYECQ 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444
		PH	25..118	CDD:278594
		Oxysterol_BP	421..767	CDD:279564	126/358 (35%)
CG42668	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		PH	238..356	CDD:278594
		Oxysterol_BP	471..796	CDD:279564	126/351 (36%)
		Prefoldin	<849..943	CDD:238453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460427
Domainoid	1	1.000	145	1.000	Domainoid score	I1472
eggNOG	1	0.900	-	-		E1_KOG2210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22451at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1082
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.880