DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1513 and Osbpl8

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001296384.1	Gene:	Osbpl8 / 314824	RGDID:	1561474	Length:	888	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	207/772 - (26%)
Similarity:	321/772 - (41%)	Gaps:	213/772 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDA-LIGIDDQEDNTF 87
            :.|||..||   |.|    .||.... ||.|.|.|:    |...|.|.|... :|....::|.
  Rat   156 IRGTLKSWT---KLW----CVLKPGV-LLIYKTQKN----GQWVGTVLLNACEIIERPSKKDG-- 206

  Fly    88 TITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRR 152
                    |.|:..|..|:..|..:                         |...|..||.|....
  Rat   207 --------FCFKLFHPLEQSIWAVK-------------------------GPKGEAVGSITQPLP 238

  Fly   153 PNHLELVARRVSEADA-----YLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKH 212
            .::  |:.|..||:|.     .|:|.::.:.||.:.:                     |.|..:|
  Rat   239 SSY--LIIRATSESDGRCWMDALELALKCSGLLKRTM---------------------MRDGKEH 280

  Fly   213 SIVSLQIAKNMAH-------PINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIG 270
               .|.|:.:..|       ..|.:::|                   :|.|....::  |.|...
  Rat   281 ---DLSISSDSTHVTLYGLLRANNLHSG-------------------DNFQLNDSEI--ERQHFK 321

  Fly   271 KGELVDDEEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAET 335
            ..::..|:.|...:.             .:..|:.|            .:|.|         .|:
  Rat   322 DQDMYSDKSDKENDQ-------------EHDESDNE------------VLGKS---------EES 352

  Fly   336 TSPTHEKAPDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDA 400
            .:.|.|:..|.:.:.|||        :.|.|                |....:|        ::.
  Rat   353 DTDTSERQDDSYIDPEPV--------EPLKE----------------TTYMEQS--------HEE 385

  Fly   401 LYE--EEEETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIK 463
            |.|  |..:|:...|.:.|:|..||.||:.||||::|||||||||.||.|:..:||:.|.|...:
  Rat   386 LGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSE 450

  Fly   464 ISDLDDPRDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVP 528
            .:..::|..|:.:|.:||:|.::  :|....||||||||||.|:|.|..|
  Rat   451 AALEENPYFRLKRVVKWYLSGFY--KKPKGLKKPYNPILGETFRCLWIHP--------------- 498

  Fly   529 WCRRDQLTF-LAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDR 592
              |.:..|| :||||||||||||||..:.......:..:..||||.|.|:.....||..:|.::|
  Rat   499 --RTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNR 561

  Fly   593 SEEYIVTFPNGYGRSIL--TVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKR--NRVSAEVY 653
            .|:|::|.|..:.:.||  |:. :||||:|.|.|.::||.|.:||..|||.|...  |::|.::
  Rat   562 GEDYVMTMPYAHCKGILYGTMT-LELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKL- 624

  Fly   654 APSEKKPFVSITGEWSGLMEAKWHDK--NKTEVF----VDVNRIPIFKKQVRPIVEQDEYESRRV 712
             ...|:...::.|.|..  |...:||  :.:|:|    .|:.:..:.:..|: ..|||::||.::
  Rat   625 -KLGKEVLATLEGHWDS--EVFINDKKTDNSEIFWNPTPDIKQWRLIRHTVK-FEEQDDFESEKL 685

  Fly   713 WKEVTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFK--PVGDNWIY 767
            |:.||..:...|...||..|:|:|:.||..|:.||..:..|..|.|:  |:...|.|
  Rat   686 WQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWACKLFELDPLTGEWHY 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	25/101 (25%)
		PH	25..118	CDD:278594	25/93 (27%)
		Oxysterol_BP	421..767	CDD:279564	131/358 (37%)
Osbpl8	NP_001296384.1	PH_OPR5_ORP8	141..270	CDD:270103	38/162 (23%)
		PH	148..264	CDD:278594	37/156 (24%)
		Oxysterol_BP	406..744	CDD:279564	133/362 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920