DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1513 and kes1

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001342777.1	Gene:	kes1 / 2540206	PomBaseID:	SPBC1271.12	Length:	388	Species:	Schizosaccharomyces pombe

Alignment Length:	419	Identity:	133/419 - (31%)
Similarity:	197/419 - (47%)	Gaps:	68/419 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 SRSASYDNGIDYDALYEEEEETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMY 451
            |::.|.|:..|      .|.:..|......:.::.|.|......||:.:..|:|||...||:| |
pombe     2 SKTTSSDDSRD------GEGDKRLRSTTKSTWLSFLKSIATFSGDLSSLTAPSFILSSTSLIE-Y 59

  Fly   452 ADYFA-HPDLFIKISDLDDPRDRIVQVCRWYMSA---YHAGRKSAVA--KKPYNPILGEVFQCHW 510
            :.|:| ||:|||.:...:.|.:|.:.|.:|:.|.   .:|.|.....  |||.||||||:|...|
pombe    60 SAYWAEHPELFISLPRGETPLERQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKW 124

  Fly   511 DIPGISQDAQEVRDGPVPWCRRDQLTFLAEQVSHHPPISAFYAEHYNKK--ITFAAHVWTKSKFL 573
            : ..|.:|.              :||  :|||||||||:|::.  ||||  :....:...||.|.
pombe   125 N-TDIGEDT--------------ELT--SEQVSHHPPITAYHI--YNKKAGVRLEGYNGHKSGFS 170

  Fly   574 GLSIGVHNIGEGVVTLVDRSEEYIVTFP----NG--YGRSILTVPWIELGGSVEIKCPQSGYYAN 632
            |..|.|..||...:.|...:|.|.:|||    .|  ||.     |:||||....| ...|||...
pombe   171 GPQIHVKQIGHARLILEPHNEVYYITFPLVTLEGLWYGS-----PYIELGKKSYI-ISTSGYLTT 229

  Fly   633 VEFLTKPFYGGKRNRVSAE-VYAPSEKKPFVSITGEWSGLME-AKWHDKNKT--EVFVDVNRIPI 693
            :|:..|.::.||:|...|. |.|.::.:|...|.|.|:|::: ..:.|:.::  |.|:|......
pombe   230 IEYSGKGYFTGKKNTFKATIVNAKTKSEPIYRIEGSWTGMLKYCTFEDQKRSAWEDFLDCGNYKP 294

  Fly   694 FKKQVRPIVEQDEYESRRVWKEVTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHF 758
            ....|.||.||.|||||||||.....|...|...|:..|..:|:.||:..:..:|::..|..|:|
pombe   295 VNISVAPIEEQGEYESRRVWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRKYF 359

  Fly   759 -----------------KPVGDN-WIYAK 769
                             :||.:. |.|.:
pombe   360 EWKDKDEGFEEATKCLRQPVKEGFWYYLR 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444
		PH	25..118	CDD:278594
		Oxysterol_BP	421..767	CDD:279564	126/381 (33%)
kes1	NP_001342777.1	Oxysterol_BP	28..370	CDD:307410	123/367 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940