DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and obr-3

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001379311.1	Gene:	obr-3 / 181495	WormBaseID:	WBGene00014215	Length:	770	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	192/697 - (27%)
Similarity:	296/697 - (42%)	Gaps:	137/697 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 PNHLELVARRVSEADAYLQLMI---------------EQTNLLDKRIAELTDP-----AEQSKCK 197
            |.|.:   ||.|.:.||.:|:.               |:..:.|:.::.|.||     |:..|.:
Worm    25 PAHKQ---RRASLSVAYHRLLSFSSSPIKKQKKEYRDEKKRVNDELLSALRDPTVVVMADTLKIR 86

  Fly   198 ALQDNANAMLDHIKHSIVSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLK- 261
            ......|.....:|..::.|...|.               |........|.:..|..::....|
Worm    87 GALKRWNRYYCVLKPGLLILYKHKK---------------ADRGDWVGTVLLNHCELIERPSKKD 136

  Fly   262 -------VPLEGQVIGKGELVDDEEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTS 319
                   .|::..:.|....:.....|.|.|    ||..........|.:....:.||.:..|..
Worm   137 GFCFKLFHPMDMSIWGNRGPLGQSFGSFTLN----PLNTSFLICRAPSDQAGRCWMDALELSFKC 197

  Fly   320 IGSSPIGCATRGFAETTSPTHEKAPDGFAN-----------------AEPVAVGDSVAPQTLPEI 367
            .|.         ..:|.:...:|..|...|                 ...:||.::.|.:...||
Worm   198 TGL---------LKKTMNELDDKNGDSSMNDGQRDESRMSRDSDGDDTRELAVSETDAEKHFQEI 253

  Fly   368 DESVADAD-TSIKTARTAVSSRSASYDN----------GIDYDALYEEEEETDLSMEAHGSMITH 421
            |: |.|.| ...|.:.|:.:.|.|..::          |.|.....|..||       :.|:|..
Worm   254 DD-VQDEDHEDGKMSETSDTIREAFTESAWIPSPKEVFGPDGSLTEEVGEE-------NKSLIWT 310

  Fly   422 LLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRDRIVQVCRWYMSAYH 486
            ||.|::.||||:||||||||||.||.||..|||:.|.||..:.....||..|||:|.::::|.::
Worm   311 LLKQIRPGMDLSKVVLPTFILEPRSFLEKLADYYYHADLISEAVAEPDPFQRIVKVTKFFLSGFY 375

  Fly   487 AGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQLTFLAEQVSHHPPISAF 551
              :|....||||||||||.|:|.|:.|          ||...:       ::|||||||||:|:.
Worm   376 --KKPKGLKKPYNPILGETFRCKWEHP----------DGSTTF-------YMAEQVSHHPPVSSL 421

  Fly   552 YAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVTFP--NGYGRSILTVPWI 614
            :..:.......:..:..|||:.|.|:.....|:..:||::..|.|||..|  |..|..|.|:. :
Worm   422 FITNRKAGFNISGTILAKSKYYGNSLSAILAGKLRLTLLNLGETYIVNLPYANCKGIMIGTMT-M 485

  Fly   615 ELGGSVEIKCPQSGYYANVEFLTKPFYGGKRNRVSAEVYAPSEKKPFVSITGEWSGLMEAKWHDK 679
            ||||.|.|:|.::||...::|..||..||..|::...:...|::  ..||.|.|.|::..|..|
Worm   486 ELGGEVNIECEKTGYRTTLDFKLKPMLGGAYNQIEGSIKYGSDR--LASIEGAWDGVIRIKGPD- 547

  Fly   680 NKTEVF-----VDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAGLKFNDIERATTAKFVVEQQQ 739
            .|.|::     |...|:|.::..:.   ||.|:||.::|:.||..:...|..:||..|..:|..|
Worm   548 GKKELWNPTPEVIKTRLPRYEINMD---EQGEWESAKLWRHVTEAISNEDQYKATEEKTALENDQ 609

  Fly   740 RDQAKVRKEYDLAWEHKHFKPV-GDNWIYA----KPLSQRMYLQEKE 781
            |.:||    ..:..|.|.||.. ||:::|.    :|......:|:.|
Worm   610 RARAK----SGIPHETKFFKKQHGDDYVYIHADYRPWDNNNDIQQIE 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444
		PH	25..118	CDD:278594
		Oxysterol_BP	421..767	CDD:279564	129/353 (37%)
obr-3	NP_001379311.1	PH_OPR5_ORP8	70..202	CDD:270103	25/159 (16%)
obr-3	NP_001379311.1	Oxysterol_BP	308..631	CDD:395990	129/352 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950