DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and obr-4

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_491691.1	Gene:	obr-4 / 172253	WormBaseID:	WBGene00016331	Length:	676	Species:	Caenorhabditis elegans

Alignment Length:	781	Identity:	308/781 - (39%)
Similarity:	436/781 - (55%)	Gaps:	138/781 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDALIGIDDQEDNTFT 88
            :||.||||||::.|||||:|.: ||..|| ||||::||:||.:||.:||..|::|||.:.::.||
Worm     1 MEGPLSKWTNMVHGWQYRWFKI-ENDTLL-YYTSREKMLKGQQRGQIRLTGAVVGIDGENNSLFT 63

  Fly    89 ITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRRP 153
            |||:.||||.|.|...||.||||.||::||                .:.||.|   ....|....
Worm    64 ITVEGKTFHMQGRDLRERNQWVRILENSIR----------------ASSGYAK---NVSVGTTPS 109

  Fly   154 NHLELVARRVSEADAYLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKHSIVSLQ 218
            .|.:   :|..||:.:|:.::|:...|::..:......|:....:|...:|.:.:::||:|:.||
Worm   110 QHFK---QRTEEANEFLKTLVEKVKALEQLKSGERAVDEKKTIDSLIAASNNLTNNVKHAIIYLQ 171

  Fly   219 IAK-----NM-------AHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGK 271
            :|:     ||       .||   ..|..|::..|..:.|
Worm   172 MAQARLDPNMKTEKLMFTHP---DLNEKPSSRETPGTVS-------------------------- 207

  Fly   272 GELVDDEEDSATENATTAPLGLI--------VPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCA 328
                     .:|:.:|..|:..|        ..|.||:||: ||:|||| |:....:
Worm   208 ---------DSTQTSTDKPISGIQHLDHLKPQRAESYASSD-EEEFYDA-DEELIDL-------- 253

  Fly   329 TRGFAETTSPTHEKAPDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAV-SSRSASY 392
                            |.|                  |.::|..::..|.:|:..|: ||....|
Worm   254 ----------------DNF------------------ESEKSGQESGDSNRTSDAAIMSSDEDGY 284

  Fly   393 DNG---IDYDALYEEEEETDLS--MEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYA 452
            |.|   .|:|.:|...||.|:.  .:.|||::.||||||.:|||||||.||||||||||||||||
Worm   285 DFGDSNEDFDEIYNNAEEHDIGNVQQDHGSVLMHLLSQVSVGMDLTKVTLPTFILERRSLLEMYA 349

  Fly   453 DYFAHPDLFIKISDLDDPRDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQ 517
            |:||||||||..:..|....|::.|.|:|:::::|.|||.|||||||.||||.|:|.:.:|..|.
Worm   350 DFFAHPDLFIATNGNDSAEKRMIAVVRYYLNSFYAARKSGVAKKPYNAILGETFRCRYSVPNSSL 414

  Fly   518 DAQEVRDGPVPWCRRDQLTFLAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNI 582
            ..::...||.|.....||||:||||||||||||||||..::.|:|.||::|||.||||||||.:|
Worm   415 SGKKTESGPWPGSDEKQLTFIAEQVSHHPPISAFYAEMPSEGISFNAHIYTKSSFLGLSIGVASI 479

  Fly   583 GEGVVTLVD-RSEEYIVTFPNGYGRSILTVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKRN 646
            |||::||.: ..|:|.:|||:||||||::.||.|.||.|:::|.::||.|::|||||||:|||.:
Worm   480 GEGILTLHNYGDEQYTITFPSGYGRSIMSTPWFEFGGKVKVECEKTGYRADIEFLTKPFFGGKPH 544

  Fly   647 RVSAEVYAPSEKKPFVSITGEWSGLMEAKWHDKNKTE-VFVDVNRIPIFKKQVRPIVEQDEYESR 710
            |:...:.....|||.:::.|||:|.|.||  .:|..| |||||...|..||:..|:::|.:.|||
Worm   545 RIQGSICRDGAKKPVLTLRGEWNGTMYAK--TQNGEEYVFVDVKAKPEVKKECVPVMQQGKRESR 607

  Fly   711 RVWKEVTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFKPVGDN--WIYAKPLSQ 773
            |:|:.|||.|..|.|:.|||:|..:||:||.:||.|.|....|....|.....:  |:|.:....
Worm   608 RLWRHVTAALLRNRIQTATTSKRFIEQRQRKEAKERLESGEKWTPLLFDTTDKDGEWMYKQKFGV 672

  Fly   774 R 774
            |
Worm   673 R 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	55/100 (55%)
		PH	25..118	CDD:278594	53/92 (58%)
		Oxysterol_BP	421..767	CDD:279564	186/349 (53%)
obr-4	NP_491691.1	PH_ORP9	1..100	CDD:241444	57/116 (49%)
		PH	1..93	CDD:278594	53/93 (57%)
		Oxysterol_BP	318..666	CDD:279564	186/349 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158425
Domainoid	1	1.000	372	1.000	Domainoid score	I474
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69380
Inparanoid	1	1.050	496	1.000	Inparanoid score	I762
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47954
OrthoDB	1	1.010	-	-		D289732at33208
OrthoFinder	1	1.000	-	-		FOG0001312
OrthoInspector	1	1.000	-	-		oto20112
orthoMCL	1	0.900	-	-		OOG6_106581
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	1	1.000	-	-		X4688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940