DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and OSBPL10

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_005264900.1	Gene:	OSBPL10 / 114884	HGNCID:	16395	Length:	769	Species:	Homo sapiens

Alignment Length:	823	Identity:	271/823 - (32%)
Similarity:	406/823 - (49%)	Gaps:	165/823 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASTTGSAPS----------------LG----------PPQSGSGGSG-----TLEGTLSKWTNVM 35
            |::.||:||                ||          ...|.|||.|     .|||.|||:||::
Human    24 ATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLL 88

  Fly    36 KGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDALIGIDDQEDNTFTI-TVDHKTFHFQ 99
            :|||.|:||||..||:|.|:.::....: ..||.:.|..|::.:.|:..:...: :.:.:.|..:
Human    89 QGWQNRYFVLDFEAGILQYFVNEQSKHQ-KPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLR 152

  Fly   100 ARHNEEREQWVRRLEDTIRRH-------ANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRRPNHLE 157
            |...:|::.||.:|....:.|       |..||   |:|...:..|             .||...
Human   153 AADAKEKQFWVTQLRACAKYHMEMNSKSAPSSR---SRSLTLLPHG-------------TPNSAS 201

  Fly   158 LVARRVSEADAYLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKHSIVSLQIAKN 222
            ..::|        .|.:....::  .|.....||...:.|:........:..:.:.:...|  ||
Human   202 PCSQR--------HLSVGAPGVV--TITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQ--KN 254

  Fly   223 MAHPINGIYNGPPATA---------STSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDDE 278
            :.|.|..:....|.||         :||::|.. .:|.|.|:        |:..|...|:  ..:
Human   255 LVHAIESLPGSGPLTALDQDLLLLKATSAATLS-CLGECLNL--------LQQSVHQAGQ--PSQ 308

  Fly   279 EDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEKA 343
            :..|:||         :.....|.|...|...:.      ::||.|...|...:|
Human   309 KPGASEN---------ILGWHGSKSHSTEQLKNG------TLGSLPSASANITWA---------- 348

  Fly   344 PDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYEEEEET 408
                           :.|.:..  ||..:..:....:....|.|.....||        |::|||
Human   349 ---------------ILPNSAE--DEQTSQPEPEPNSGSELVLSEDEKSDN--------EDKEET 388

  Fly   409 DLS-MEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDPRD 472
            :|. ||...|:|.||:||:|:|||||||||||||||:|||||||||:.|||||.:.|:....|.:
Human   389 ELGVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEE 453

  Fly   473 RIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIP-------------GISQDAQEVRD 524
            |::....:|::|:|.|||.|:||||||||:||.|.|.|::|             ..|.....:.|
Human   454 RVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMAD 518

  Fly   525 GPVPWCRRDQLTFLAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTL 589
            .|   .:..:|.|:|||||||||||.||.|...|::....||||||||:|:|:||..|||||:.|
Human   519 DP---SKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRL 580

  Fly   590 VDRSEEYIVTFPNGYGRSILTVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKRNRVSAEVYA 654
            ::..|||:.|.|:.|.|||||:||:||||.|.|.|.::||.|.|.|.||||||||.:||:|||
Human   581 LEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV-- 643

  Fly   655 PSEKKPFVSIT----GEWSGLMEAKWHDKNKTEVFVDVNRIPIFKKQVRPIVEQDEYESRRVWKE 715
              :..|..:|.    |||:|.:|..::: .:|:| :|...:|::.|::||:.:|...|||.:|:|
Human   644 --KHNPTNTIVCKAHGEWNGTLEFTYNN-GETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLWRE 704

  Fly   716 VTAGLKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHF 758
            ||..|:..||:.||..|..:|::||.:.:.|:.....|:.|:|
Human   705 VTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	33/108 (31%)
		PH	25..118	CDD:278594	30/93 (32%)
		Oxysterol_BP	421..767	CDD:279564	169/355 (48%)
OSBPL10	XP_005264900.1	PH_ORP10_ORP11	77..183	CDD:270106	33/106 (31%)
		PH	78..171	CDD:278594	30/93 (32%)
		Oxysterol_BP	402..750	CDD:279564	169/355 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289732at33208
OrthoFinder	1	1.000	-	-		FOG0001312
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R635
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850