DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1513 and OSBPL8

DIOPT Version :9

Sequence 1:	NP_610534.3	Gene:	CG1513 / 36028	FlyBaseID:	FBgn0033463	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_016874257.1	Gene:	OSBPL8 / 114882	HGNCID:	16396	Length:	912	Species:	Homo sapiens

Alignment Length:	765	Identity:	207/765 - (27%)
Similarity:	318/765 - (41%)	Gaps:	199/765 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDA-LIGIDDQEDNTF 87
            :.|||..||   |.|    .||.... ||.|.|.|:    |...|.|.|... :|....::|.
Human   180 IRGTLKSWT---KLW----CVLKPGV-LLIYKTQKN----GQWVGTVLLNACEIIERPSKKDG-- 230

  Fly    88 TITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRR 152
                    |.|:..|..|:..|..:                         |...|..||.|....
Human   231 --------FCFKLFHPLEQSIWAVK-------------------------GPKGEAVGSITQPLP 262

  Fly   153 PNHLELVARRVSEADA-----YLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKH 212
            .::  |:.|..||:|.     .|:|.:                    ||.:|          :|.
Human   263 SSY--LIIRATSESDGRCWMDALELAL--------------------KCSSL----------LKR 295

  Fly   213 SIVSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDD 277
            ::    |.:...|.:        :.:|.|:..:...:...||:.:|. ...|....|.:....|.
Human   296 TM----IREGKEHDL--------SVSSDSTHVTFYGLLRANNLHSGD-NFQLNDSEIERQHFKDQ 347

  Fly   278 EEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEK 342
            :                    .||....:|:..:..:.....:|.|         .|:.:.|.|:
Human   348 D--------------------MYSDKSDKENDQEHDESDNEVMGKS---------EESDTDTSER 383

  Fly   343 APDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYE--EE 405
            ..|.:...|||        :.|.|                |..:.:|        ::.|.|  |.
Human   384 QDDSYIEPEPV--------EPLKE----------------TTYTEQS--------HEELGEAGEA 416

  Fly   406 EETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDP 470
            .:|:...|.:.|:|..||.||:.||||:||||||||||.||.|:..:||:.|.|...:.:..::|
Human   417 SQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENP 481

  Fly   471 RDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQL 535
            ..|:.:|.:||:|.::  :|....||||||||||.|:|.|..|                 |.:..
Human   482 YFRLKKVVKWYLSGFY--KKPKGLKKPYNPILGETFRCLWIHP-----------------RTNSK 527

  Fly   536 TF-LAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVT 599
            || :||||||||||||||..:.......:..:..||||.|.|:.....||..:|.::|.|:|::|
Human   528 TFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMT 592

  Fly   600 FPNGYGRSIL--TVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKR--NRVSAEVYAPSEKKP 660
            .|..:.:.||  |:. :||||:|.|.|.::||.|.:||..|||.|...  |::|.::  ...|:.
Human   593 MPYAHCKGILYGTMT-LELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKL--KLGKEV 654

  Fly   661 FVSITGEWSGLMEAKWHDK--NKTEVF----VDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAG 719
            ..::.|.|..  |....||  :.:|||    .|:.:..:.:..|: ..||.::||.::|:.||..
Human   655 LATLEGHWDS--EVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVK-FEEQGDFESEKLWQRVTRA 716

  Fly   720 LKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFK--PVGDNWIY 767
            :...|...||..|:|:|:.||..|:.||..:..|..|.|:  |:...|.|
Human   717 INAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHY 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	25/101 (25%)
		PH	25..118	CDD:278594	25/93 (27%)
		Oxysterol_BP	421..767	CDD:279564	132/358 (37%)
OSBPL8	XP_016874257.1	PH_OPR5_ORP8	165..294	CDD:270103	40/192 (21%)
OSBPL8	XP_016874257.1	Oxysterol_BP	430..767	CDD:395990	134/362 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D949920at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820