Protein Alignment Sec24AB and SFB3

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_011966.1
• Gene: SFB3 / 856498
• SGDID: S000001140
• Length: 929
• Species: Saccharomyces cerevisiae
• Alignment Length: 914
• Identity: 214/914 - (23%)
• Similarity: 384/914 - (42%)
• Gaps: 156/914 - (17%)

  Fly   374 GTQPTGAPLQYQAQAPPQAYGQHPQQAPQTAPGGPYG---------TTAPLNVAQQGF-----SR 424
            ||.||   |.......||...|...|.||......:|         .:.|:.|:|:.|     |.
Yeast    44 GTVPT---LGNSPYTTPQLNQQDGFQQPQAFTPKQFGGFNNGSGSVMSTPVMVSQERFGASEASS 105

  Fly   425 LWGQDTIDL---MQNRHILTPATLPPPKVVLHNQF---HESI--------------NCSPSIMRC 469
            .:||..:|:   ....||:...........|...|   .:|:              :|.|.:|..
Yeast   106 PYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDSVPPLPTTQFYCVDQGSCDPHLMSL 170

  Fly   470 TLTKIPESNSLLQKSRLPLGIVIHPF-------RDVNSLPVIQCINIVRCRLCRTYINP-FVYFV 526
            ::..||||..|...::||||:.|.||       .:|.::|:......:|||.||.|.|| |.:..
Yeast   171 SMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDGTPLRCRRCRAYANPKFQFTY 235

  Fly   527 DSKMWKCNLCYRVNELPDDFQFDP--ATKTYGDVTRRPEVRSSTIEFIAPSEY---MLRPPQPAM 586
            ||.: .||:|....::|.: .|.|  ......|:..:.|:...|::|:.||.|   ..:...|..
Yeast   236 DSSV-ICNICRVKMQVPGE-HFAPMGPNGQRSDLNEKSELLHGTVDFLVPSIYNAIQEKELLPLH 298

  Fly   587 YLFLFDVSIIAQQSG----YLEAACAVLNRHLDEMPGDARTQVGFICFDSFVHFYSMAEGLNQPH 647
            |:||.|||::|.::|    .:|...:.:....|..|   ..:|..|.:|:.:.|:::...|:...
Yeast   299 YVFLIDVSLLANENGSSLAMVEGVRSCIEYISDFQP---NCEVAIIVYDNKLRFFNLRPDLDNAQ 360

  Fly   648 EMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFA---HTHDPGSALGAALQVAFKLMQ 709
            |..:.:::|.|||..:.|.|......:::.|.|.::....:   ::|.|....|:|||.|...:.
Yeast   361 EYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDKYSHVPQVCYGSALQAAKLALD 425

  Fly   710 ----ASGGRITVFQSCLPNKGPGALEPREDPNNRSAKDVAHLNPATDFYKRFALECSGYQIACDL 770
                ..||:|....:.||..|.|.|..:.|..:     :||:.....|||:.|.:.....|:.||
Yeast   426 TVTGGQGGKIICSLNSLPTIGNGNLSLKRDNAH-----IAHVKCDNGFYKKLASDFLKSYISLDL 485

  Fly   771 FLMNQQYSDMATISGISKHSGGCVHHFPLYQKTKP------HMVESFRSCFKRYLTRKIGFEAVM 829
            ::.|..:.||||:....:.:.|.:.::|.:|:...      .||.:        ::..:|::|::
Yeast   486 YVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVNDMVTN--------VSNIVGYQALL 542

  Fly   830 RIRCTRGLQVHTFHGNFFVRSTDLLS----LPNVNPDAGYGMQISYEESLTDAKTICFQAALLYT 890
            ::||:.||.|.    .::..|:|...    :|.:..|....:.:.|:..:.....:.||.|||||
Yeast   543 KVRCSTGLSVE----QYYCDSSDNTDHDPIIPVLTRDTTLDVLLKYDSKIKTGTDVHFQTALLYT 603

  Fly   891 NSEGERRIRVHTVCLPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVY 955
            :.:|.|::|.......|:.::.|:....:...::.::.|     .|...|.|.....|...||..
Yeast   604 DIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIK-----DVIKTLGDCDFVKIRRLIDDK 663

  Fly   956 NAFKIAQN---LPSGQSGQLIAPRSLALLPLYILALLKHPAFRVGT-STRLDDRVYAMDCMKTLP 1016
            ....:.|.   :.|..|.|||.|.|:..||.|:||..|....:... |||.::|:|.:....:|.
Yeast   664 MVEILTQYRGLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNERIYDLLKYDSLN 728

  Fly  1017 LDQLMKYVYPE-------LYKIDALIYHARNSNISSNQDDDEDEDEPLPELPRLQLSAEHLD--S 1072
            ..||...:||:       |.:.|...|.|.:..:..|..          .:..|.:.|.|.:  :
Yeast   729 SAQLCYKLYPQIVPFHVLLEETDLTFYDANDKLLQINSS----------SINNLSVRASHSNFIN 783

  Fly  1073 RSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISST---AELGDYVYGLP-----------NVVSNE 1123
            ...:|:..|..|.::...|....:|:.:|.:..:   :::..:...||           ||:.|.
Yeast   784 GGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISLFSGTLPETGTSINQKASNVIKNW 848

  Fly  1124 NDVLKR-----FILRLNYDKPYSALVQIIRDTSTAKGQFTERLTDDRSESSLSYYE---FLQHIR 1180
            ..|:.:     .:||.|.|:.||.::             ::.|.:|::.:.:..|:   .:.|.:
Yeast   849 QQVVNKSSLPLVLLRPNVDQYYSNVM-------------SQLLCEDKTVNRIESYDNYLVIMHKK 900

  Fly  1181 AQVK 1184
            .|.|
Yeast   901 IQEK 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	17/65 (26%)
		COG5028	383..1184	CDD:227361	208/903 (23%)
SFB3	NP_011966.1	COG5028	1..903	CDD:227361	212/911 (23%)