Protein Alignment Sec24AB and SFB2

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_014349.1
• Gene: SFB2 / 855678
• SGDID: S000004994
• Length: 876
• Species: Saccharomyces cerevisiae
• Alignment Length: 997
• Identity: 288/997 - (28%)
• Similarity: 453/997 - (45%)
• Gaps: 219/997 - (21%)

  Fly   277 RPTPAGQRIPYGVPPPTNPEQQSQQNNNLQNAPPPPRVGAVWPPSLPNVAAPGAQPMMPPAQQTP 341
            |..|..| :||....|...|||..|....|.|      .|:....|.|.|....|  :...||.|
Yeast     7 RVYPQAQ-VPYIASMPIVAEQQQSQQQIDQTA------YAMGNLQLNNRANSFTQ--LAQNQQFP 62

  Fly   342 -------QTYPYSQVYQPGPQQQPPPPQSAVQPPPPGMFGTQPTGAPLQYQAQAPPQAYGQHPQQ 399
                   |.||....     .:.|||.:....||
Yeast    63 GSGKVVNQLYPVDLF-----TELPPPIRDLSLPP------------------------------- 91

  Fly   400 APQTAPGGPYGTTAPLNVAQQGFSRLWGQDTIDLMQNRHILTPATLPPPKVVLHNQFHESINCSP 464
                         .|:.::|.                 :|:||:              |..|...
Yeast    92 -------------LPITISQD-----------------NIVTPS--------------EYSNVPY 112

  Fly   465 SIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDV----NSLPVIQCINIVRCRLCRTYINPFVYF 525
            ..:|.||..:|::||||:|::||..|||.|:..:    |.:|:.....|||||.||:|:||||.|
Yeast   113 QYVRSTLKAVPKTNSLLKKTKLPFAIVIRPYLHLQDSDNQVPLNTDGVIVRCRRCRSYMNPFVVF 177

  Fly   526 VD-SKMWKCNLCYRVNELPDDFQFD------PATKTYGDVTRRPEVRSSTIEFIAPSEYMLRPPQ 583
            :: .:.|:||:|...|::|  |.||      |..:     ..|.|:::|.::::||.||.:|.|.
Yeast   178 INQGRKWQCNICRFKNDVP--FGFDQNLQGAPINR-----YERNEIKNSVVDYLAPVEYSVREPP 235

  Fly   584 PAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPG-DARTQVGFICFDSFVHFYSMAEGLNQPH 647
            |::|:||.|||..|.::|.|..:...:..:::.:|. |.||::..||.|..:|::.:.  |:..:
Yeast   236 PSVYVFLLDVSQNAVKNGLLATSARTILENIEFLPNHDGRTRIAIICVDHSLHYFYVP--LDDDY 298

  Fly   648 EMT-------------------------------LLDIEDPFLPRP-DSLLVNLKECKELVRDLL 680
            |::                               :.|:::||||.| |.|:|.||.||..:..||
Yeast   299 EVSDEDDEESDGEEEDEDEEEEDVDNSETIQMFDIGDLDEPFLPMPSDELVVPLKYCKNNLETLL 363

  Fly   681 KQLPKRFAHTHDPGSALGAALQVAFKLMQASGGRITVFQSCLPNKGPGALE----------PRED 735
            |::|:.|..||....|||.||:.|..|::::||::.|..|.|||.|.|.|:          |:|.
Yeast   364 KKIPEIFQDTHSSKFALGPALKAASNLIKSTGGKVEVISSTLPNTGIGKLKKRSEQGILNTPKES 428

  Fly   736 PNNRSAKDVAHLNPATDFYKRFALECSGYQIACDLFLMNQQYSDMATISGISKHSGGCVHHFPLY 800
            ....|.||        .|||.|.:||:..||..|:||.::.|.|:||:|.:.:.|||..|.:|.:
Yeast   429 SQLLSCKD--------SFYKTFTIECNKLQITVDMFLASEDYMDVATLSHLGRFSGGQTHFYPGF 485

  Fly   801 QKTKPHMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQVHTFHGNFFVRSTDLLSLPNVNPDAGY 865
            ..|..:.|..|.....|:|:..|..|||||:||:.||:..:|.|:||.||:||.:...:..|..|
Yeast   486 NATSLNDVTKFTRELSRHLSMDISMEAVMRVRCSTGLRATSFFGHFFNRSSDLCAFSTMPRDQSY 550

  Fly   866 GMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTVCLPVTASLPEVMHSADTEAIIGLLSKM 930
            ...||.|:||. |:....|.:.|.|.:.|||||||.|:.||.:.|..||..|||..||...:::.
Yeast   551 LFGISIEDSLM-AEYCYLQVSTLLTLNTGERRIRVMTLALPTSESAREVFASADQLAITDFMTQN 614

  Fly   931 AVDRSVASNLSDARDAFINATIDVYNAFK---IAQNLPSGQSGQLIAPRSLALLPLYILALLKHP 992
            ||.:::.|::..|||....:..|:.||:|   ...|:.|..|..|.|  :|.:|||.:..|.||.
Yeast   615 AVTKALNSSMYSARDFITKSLEDILNAYKKEISMSNINSVTSLNLCA--NLRMLPLLMNGLSKHI 677

  Fly   993 AFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYKIDALIYHARNSNISSNQDDDEDEDEPL 1057
            |.|.|. ...|.|..|::.::|.||..|:|.:||.:|.:                 .|..::..|
Yeast   678 ALRPGV-VPSDYRASALNRLETEPLHYLIKSIYPTVYSL-----------------HDMPDEVGL 724

  Fly  1058 PE------LPR-LQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISSTAELGDYVYG 1115
            |:      ||. :..:....:...::|:|....:.::||.:..|::|..|....:.:::......
Yeast   725 PDFEGKTVLPEPINATISLFERYGLYLIDNSAELFLWVGGDAVPELLIDVFNTDTISQIPVGKSE 789

  Fly  1116 LPNVVSNE---NDVLKRFI--LRLNYDKPYSALVQIIR--------------DTSTAKGQFTERL 1161
            ||  :.|:   |:.|:|.|  :|.|.|......:.|||              |.::.:......|
Yeast   790 LP--LLNDSPFNERLRRIIGRIRENNDTITFQSLYIIRGPSINEPANLNSEKDMASLRLWVLSTL 852

  Fly  1162 TDDRSESSLSYYEFLQHIRAQV 1183
            .:|:..:..||.|:||.::..:
Yeast   853 VEDKVLNCASYREYLQSMKTSI 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	30/155 (19%)
		COG5028	383..1184	CDD:227361	260/884 (29%)
SFB2	NP_014349.1	COG5028	1..876	CDD:227361	288/997 (29%)