Protein Alignment Sec24AB and Sec24a

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_780464.2
• Gene: Sec24a / 77371
• MGIID: 1924621
• Length: 1090
• Species: Mus musculus
• Alignment Length: 1177
• Identity: 492/1177 - (41%)
• Similarity: 663/1177 - (56%)
• Gaps: 194/1177 - (16%)

  Fly   108 RPPAANGPPLT-NGSNGASSANSSRTASPRPVGAAPQYAQGPIAAALNNPPLAS---------GL 162
            |.|||.|...: ...|||:||:.|            .|..||:...|.:|.::|         |.
Mouse     5 RIPAARGAAASLQAQNGAASASGS------------PYTNGPVHNTLMSPQVSSSQGYDSQPPGS 57

  Fly   163 RPSPQPTHQSLANLTSNLENLNLNTTRANGGTSILPQPQTQQQYAPTVTQKDGRGVASAQTGPPQ 227
            .|.|.|.           :.||..:.::|.|.|   |...|...:|.||  .|..:.|..:||
Mouse    58 YPRPMPA-----------KTLNPFSAQSNYGGS---QGSGQTLNSPLVT--SGPVLPSLHSGP-- 104

  Fly   228 FNDANSLLAASGVAAALVPNAMATPFSGQKPPNLAPNPAKMFGSASMAGRPTPAGQRIPYGVPPP 292
                             ||. |..|.|        .||         |..|.|:|..:|...|||
Mouse   105 -----------------VPR-MPLPTS--------QNP---------AATPMPSGSFLPGANPPP 134

  Fly   293 T-----NPEQQSQQNNNLQNAPPP--------------------------PRVGAVWP---PSLP 323
            .     |......|.|:..:..||                          .:.|:..|   |.||
Mouse   135 PLNWQYNYPSTGPQTNHFPHVAPPTLPGNPNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLP 199

  Fly   324 NVAAPGAQPMMPPAQQTPQTYPYSQVYQPGPQQQPPPPQSAVQPPP------------------- 369
            ....|||.|..|||...|.:        .||..|..||::|  |||
Mouse   200 PTFQPGAPPGPPPAGGPPPS--------RGPAPQKTPPRAA--PPPSFNSAVNQEGITSNANNGS 254

  Fly   370 ------------------PGMFGTQP----------TGAPLQYQAQAPPQA--------YGQHPQ 398
                              |.:....|          ...|..||..|||.|        |...||
Mouse   255 TAAHNTYDEIEGGGFLATPQLVNQNPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQ 319

  Fly   399 QAPQTAPGGPYGTTAPLNVAQQGFS-RLWGQDTIDLMQNRHILTPATLPPPKVVLHNQFHESINC 462
            ...||..|..:     |..:..|.| ...|...::|:|.|::|....|.||...|.... :.:||
Mouse   320 AFTQTPLGANH-----LTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVPNLLEDI-QKLNC 378

  Fly   463 SPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDVNSLPVIQCINIVRCRLCRTYINPFVYFVD 527
            :|.:.|||||.:|::.:||.|::||||:::|||:|:..|||:....|||||.|||||||||.|:|
Mouse   379 NPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVNFLD 443

  Fly   528 SKMWKCNLCYRVNELPDDFQFDPATKTYGDVTRRPEVRSSTIEFIAPSEYMLRPPQPAMYLFLFD 592
            .:.||||||||||::|::|.::|.|:.||:..:||||:::||||:||||||||||||.:|||:||
Mouse   444 QRRWKCNLCYRVNDVPEEFMYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFD 508

  Fly   593 VSIIAQQSGYLEAACAVLNRHLDEMPGDARTQVGFICFDSFVHFYSMAEGLNQPHEMTLLDIEDP 657
            ||..|.::|||.:.|..|..:||.:||:.||::|||.|||.:||||:.|||:||..:.:.||:|.
Mouse   509 VSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDV 573

  Fly   658 FLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAFKLMQASGGRITVFQSCL 722
            |:|.|::|||||.|.||||:||||.||:.|..|.:..||||.|||.||||:..:|||::|||:.|
Mouse   574 FIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQL 638

  Fly   723 PNKGPGALEPREDPNNRSAKDVAHLNPATDFYKRFALECSGYQIACDLFLMNQQYSDMATISGIS 787
            |..|.|||:|||:||.||:....||.|:|||||:.||:|||.|.|.||||::.||||:|::..||
Mouse   639 PTLGVGALKPREEPNQRSSAKEIHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCIS 703

  Fly   788 KHSGGCVHHFPLY-QKTKPHMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQVHTFHGNFFVRST 851
            ::|.|.|:::|.| .:..|..|:..:....||||||||||||||||||:||.:||||||||||||
Mouse   704 RYSAGSVYYYPSYHHQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRST 768

  Fly   852 DLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTVCLPVTASLPEVMH 916
            ||||||||||||||.:|:|.||||||.:.:.||:|||||:|:|||||||||:||||.::|.||..
Mouse   769 DLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFL 833

  Fly   917 SADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAFKIAQNLPSGQSGQLIAPRSLALL 981
            .||.:||.|||:.|||||||.::|||||||.:||.||..:|::  .::.|||...|:.|.||.|.
Mouse   834 GADVQAISGLLANMAVDRSVTASLSDARDALVNAVIDSLSAYR--SSVLSGQQPGLMVPFSLRLF 896

  Fly   982 PLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYKIDALIYHARNSNISSN 1046
            ||::|||||..:|:.|||.|||:|::||..:|:.||..||...:|.||::|.|          |:
Mouse   897 PLFVLALLKQKSFQTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLYRVDNL----------SD 951

  Fly  1047 QDDDEDEDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISSTAELGD 1111
            :......|..:|:.|.||||.|.|.....||||.|:|:|::||.|...:.|..|||:.:.|.:..
Mouse   952 EGALNINDRTIPQPPILQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLSQVLGVQNYASIPQ 1016

  Fly  1112 YVYGLPNVVSNENDVLKRFILRLNYDKPYSALVQIIRDTSTAKGQFTERLTDDRSESSLSYYEFL 1176
            .:..||.:.:.|:..:..||..|...:|:..::.:||:.|..|..|.:.|.:||:||:|||||||
Mouse  1017 TMTDLPELDTPESARIAAFISWLREQRPFFPVLYVIREESLMKAAFLQSLVEDRTESALSYYEFL 1081

  Fly  1177 QHIRAQV 1183
            .||:.||
Mouse  1082 LHIQQQV 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	95/417 (23%)
		COG5028	383..1184	CDD:227361	412/811 (51%)
Sec24a	NP_780464.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..260		77/329 (23%)
		PHA03247	<5..367	CDD:223021	103/441 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..325		13/52 (25%)
		COG5028	295..1090	CDD:227361	412/812 (51%)
		Zinc finger-like	428..452		17/23 (74%)
		Gelsolin-like. /evidence=ECO:0000255	963..1036		26/72 (36%)