Protein Alignment Sec24AB and sec24c

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: XP_031760998.1
• Gene: sec24c / 733829
• XenbaseID: XB-GENE-1003364
• Length: 1184
• Species: Xenopus tropicalis
• Alignment Length: 1293
• Identity: 332/1293 - (25%)
• Similarity: 547/1293 - (42%)
• Gaps: 247/1293 - (19%)

  Fly     7 NFVPPAHAPMPLNGNNFVNGVQGSVQQQPGPPPGQQYIPQKQPQQFQQPPPAAAFPGAGAPGNVP 71
            ::..|.:|..|::|.....|..||:|......|.|.::            .::.||..|:
 Frog    20 SYQQPVYAGQPISGGPQYPGYNGSLQGYSQHTPTQGFL------------SSSGFPVKGS----- 67

  Fly    72 PPQQFNSG----ITNQFL---------PPTSGAAT------------------------PL---Q 96
             |..|.||    ||:.:|         ||.|.|.|                        |:   .
 Frog    68 -PDSFTSGTSSPITSDYLGHHGNLMGAPPVSAAPTIAGQSLPAEQELYSQYGQGDIHNGPVTNQM 131

  Fly    97 QLPPST---LPPHLRPPAANGPP------------LTNGSNGASSANSSRTASPRPVGAAPQY-A 145
            |.||.:   :.|...|.||:..|            |||...|....|   .|:..|...|..| :
 Frog   132 QRPPVSMRYMQPGTGPQAASFQPYTPSSASAQQQQLTNQMMGMQIGN---IAASTPTSTAMGYGS 193

  Fly   146 QGPIAAALNNPPLA-SGLRPS------PQPTHQSLANLTSNLENLNLNTTRANGGTSILPQPQ-T 202
            |.|:..:..|.|.| ||.:||      |.|                :|.|:....|| |||.| .
 Frog   194 QNPLQPSSGNFPTAGSGFQPSYSNSQGPPP----------------INLTQGMPPTS-LPQSQPP 241

  Fly   203 QQQYAPTVTQKDGRGVASAQTGPPQFNDANSLLAASGV---AAALVPNAMATPFSGQKPPNLAPN 264
            ||::|               :|||..|..:|  .|.|.   :||.:|.:..:|..|.:.|
 Frog   242 QQRFA---------------SGPPPQNLPSS--QAPGFPPPSAAQMPPSYVSPSGGPQQP----- 284

  Fly   265 PAKMFGSASMAGRPTPAGQRIPYGVPPPTNPEQQSQQNNNLQNAPPPPRVGAVWPPSLPNVAAP- 328
                     :...|..:||.:|  .||..:|        ||.:...||..|.   |.:|.:..|
 Frog   285 ---------VTQGPPLSGQALP--APPLAHP--------NLASPTQPPMPGV---PLIPTMTGPQ 327

  Fly   329 GAQPMMPPAQQ------------------TPQTYPYSQVY--QPGPQQQPPPPQSAVQPPPPGMF 373
            |..|.||.:|.                  .|.|||.:..|  |||.|..|.|      |||....
 Frog   328 GPPPHMPSSQDGFSQQNGSFGQVKGPQPGYPVTYPRAPNYGSQPGLQGPPAP------PPPAPQK 386

  Fly   374 GTQPTGAPLQYQAQAPPQAYGQHPQQAPQTAPGGPYGTTAPLNVAQQGFSRLWGQDTIDLMQNRH 438
            ...|...|.....:.|||...:| :..|...|       :|:.|.:...:.. |.:.....|...
 Frog   387 RLDPDSIPSPQANELPPQQKTRH-RIDPDAIP-------SPIQVIEDDKNNR-GSEPFITGQRGQ 442

  Fly   439 ILTPATLPPPKVVLHNQFHESINCSPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDV--NSL 501
            :       ||.:..:....:..|.||..:|||....|.|:.:.::|::||..||.|...:  :.|
 Frog   443 V-------PPLITTNVLVKDQGNTSPRYIRCTSYNFPASSDMAKQSQVPLAAVIKPLATLPPDEL 500

  Fly   502 PVIQC----INIVRCRLCRTYINPFVYFVD-SKMWKCNLCYRVNELPDD-FQFDPATKTYGDVTR 560
            |....    ...:||..|:.|:.||:.|:: .:.::|..|..|.|:|.. ||....|....|...
 Frog   501 PPFLVDHGETGPIRCNRCKAYMCPFMQFIEGGRRFQCCFCSCVTEVPTHYFQHLDHTGRRVDCYE 565

  Fly   561 RPEVRSSTIEFIAPSEYML--RPPQPAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPGDART 623
            |||:...:.||.|..:|..  :.|.|..::|:.|||..|.:||.:...|..|.:.:|.:|.:...
 Frog   566 RPELSMGSYEFTATVDYCKNNKTPNPPAFIFMIDVSYNAVKSGLVALVCEELKQLVDYLPREGSM 630

  Fly   624 Q-----VGFICFDSFVHFYSMAEGLNQPHEMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQL 683
            :     |||:.::..:|||::...|.||..|.:.|:.|.|:|..|..|||:.|.:.::..||.|:
 Frog   631 EESVIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVSDMFVPLLDGFLVNVNESRTVINSLLDQI 695

  Fly   684 PKRFAHTHDPGSALGAALQVAFKLMQAS--GGRITVFQSCLP-NKGPGALEPREDPN-NRSAKDV 744
            |:.||.|.:..:.....:|...:.::|:  .|::.:|.:.|| .:.||.|:.|:|.. ..:.|:.
 Frog   696 PELFADTRETETVFAPVIQAGLEALKAADCAGKLFIFHTTLPIAEAPGKLKNRDDKKLVNTDKEK 760

  Fly   745 AHLNPATDFYKRFALECSGYQIACDLFLMNQQYSDMATISGISKHSGGCVHHFPLYQKTKPHMVE 809
            ....|.|:||...:.:|.......||||...|:.|:||:..:...:||.|:.:..:|.....  |
 Frog   761 ILFQPQTNFYNNLSKDCVAQGCCVDLFLFPNQFLDVATLGVVPFQTGGSVYKYTFFQPETDK--E 823

  Fly   810 SFRSCFKRYLTRKIGFEAVMRIRCTRGLQVHTFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEES 874
            .|.:..:|.:.::|||:||||:|.:.|::...|.|.|::.:|..:.|..::.|....::..:::.
 Frog   824 RFLNDLRRDVQKEIGFDAVMRVRTSTGIRATDFFGAFYMSNTTDVELAGLDCDKTITVEFKHDDK 888

  Fly   875 LTDAKTICFQAALLYTNSEGERRIRVHTVCLPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASN 939
            |.:......|.|:|||:..|:||:|||.:.|.....|.::..:.:|:.:|...:|.|. |.|.||
 Frog   889 LNEDTGALLQCAILYTSCGGQRRLRVHNMALNCCTQLADLYRNCETDTLINYFAKFAF-RGVLSN 952

  Fly   940 -LSDARDAFINATIDVYNAFKIAQNLPSGQS-GQLIAPRSLALLPLYILALLKHPAFRVGTSTRL 1002
             ....||..||....:...::  :|..|..| ||||.|..:.|||:|:..:||....:.|....:
 Frog   953 PTKTVRDTLINQCAQILACYR--KNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEMTI 1015

  Fly  1003 DDRVYAMDCMKTLPLDQLMKYVYPELYKIDALIYHARNSNISSNQDDDEDEDEPLPELP-RLQLS 1066
            |||.|....:.::.:.....:.||.|..:             |..|...|      .|| .::.|
 Frog  1016 DDRTYIRQLVSSMDVADSNVFFYPRLLPL-------------SKMDPSND------SLPVAIRSS 1061

  Fly  1067 AEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISSTAELGDYVYGLP---NVVSNENDVLK 1128
            .|.|....::|::.|..:.::||.|:...:::.:..:||.:::...:..||   |.:||:   ::
 Frog  1062 EERLSKGEMYLLENGLNLFVWVGANIQQSLIQNLFNVSSFSQIDSSMSALPVLDNPISNK---IR 1123

  Fly  1129 RFILRLNYDKP-YSALVQIIRDTSTAKGQFTERLTDDRS-ESSLSYYEFLQHIRAQVK 1184
            ..|......:| |..|: |::.....:..|...|.:|:: ....||.:||.|:..:::
 Frog  1124 GIITMFRAQRPRYMKLI-IVKQDDKIEMLFKHLLVEDKNLNGGASYVDFLCHMHKEIR 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	109/441 (25%)
		COG5028	383..1184	CDD:227361	218/827 (26%)
sec24c	XP_031760998.1	Atrophin-1	10..>396	CDD:460830	114/463 (25%)
		COG5028	303..1180	CDD:227361	248/937 (26%)