Protein Alignment Sec24AB and Sec24b

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: XP_038958034.1
• Gene: Sec24b / 295461
• RGDID: 1309358
• Length: 1294
• Species: Rattus norvegicus
• Alignment Length: 1329
• Identity: 513/1329 - (38%)
• Similarity: 709/1329 - (53%)
• Gaps: 196/1329 - (14%)

  Fly    11 PAHAPMPLNGNNFVNGVQGSVQ-----QQPGPPPGQQYIPQKQ--PQQFQQPPPAAAFPGAGAPG 68
            ||.:|.|..|......:.|:|.     ||.||...|..:|...  |.|....|......|.|...
  Rat     4 PAGSPHPAAGARMPPKLGGAVSGLAPPQQNGPAQSQMQVPSGYGLPHQNYMAPSGHYSQGPGKMT 68

  Fly    69 NVPPPQQFNSGITNQFLPPTSGAATPLQQLPPST--------LPPHLRP---------------- 109
            ::|...|..:..:..:..||....||.....|..        ..||:..
  Rat    69 SLPLDNQCENYYSRPYTAPTQNVGTPSSANQPGAQLMYGRGPSAPHMGASMPGPFQGAPASASHS 133

  Fly   110 -PAANGPPLTNGSNGASSANSSRTASPRPVGAAPQYAQGPIAAALN--NPPLASGLRPSPQPTHQ 171
             |:|:.|..:.|:..:|.|..|.|||....|.....:..||:...|  .|.::....|:.:|..|
  Rat   134 YPSASQPYSSLGNRYSSPATYSATASVASQGYPSTCSHYPISTVSNVVYPNVSYPSLPASEPYGQ 198

  Fly   172 SLANLTSNLENLNLNTTRANGGTSIL------PQP---QTQQQYAPTVTQKDGRGVASAQTGPPQ 227
            ...:.::......|..:.:...|::.      |.|   |.|||......|:...|.:|.....|.
  Rat   199 MFTSQSAPPPARPLKESYSGPSTAVAYPSRPPPPPSQHQQQQQQQQQQQQQSHSGYSSLPWSGPG 263

  Fly   228 FNDANSLLAASGVAAALVPN---------AMATPFSGQKPPNLAPNPAKMFGSASMAGRPTPAGQ 283
            ...|...|..:.:.:..:||         :::.|.:....|   |.|:.:..:.    .|.|:..
  Rat   264 LPPAQDSLIRNQMGSLAIPNSHPAINVADSLSCPITENVQP---PKPSSVVATV----LPGPSST 321

  Fly   284 RIPYGVPPPTNPEQQSQQNNNLQNAPPPP------------------------RVGAVW------ 318
            |:|   |.|::|.      ..:.:|||||                        |...:|
  Rat   322 RMP---PAPSHPV------GPVPSAPPPPEQMQTKVRFPVPSHAGCGKWRPVNRDPGLWGTYIGR 377

  Fly   319 ----PPS------------LPNVAAPGAQPMMPPAQQTPQ------------------------- 342
                ||.            :.|.|:....|:...:....:
  Rat   378 MRERPPEKFANKGMQYGDYVNNQASSTPTPLSSASDDEEEEDEDEEAGVDSSSTTSSASPLPNSY 442

  Fly   343 ------TYP---YSQVYQPGPQQQPPPPQSAVQPPPPGM-------FG-TQPTGAPLQYQAQAPP 390
                  :||   .|....|.|.:.|.|..:.|..|....       || ..||..|....|.|||
  Rat   443 DALEGGSYPDMHSSSASSPVPDRAPEPNSTLVPTPTAAQPAKVAKPFGYGYPTLQPAYQNAAAPP 507

  Fly   391 -------QAYGQHPQQAPQTAPGGPYGTTAPL-NVAQQGFSRLWGQDTIDLMQNRHIL--TPATL 445
                   .||..:|||.|     |.:..::.| .::.|...:......::|.|.::||  ||...
  Rat   508 TTAHPSGPAYSGYPQQYP-----GVHQLSSGLGGLSLQSSPQPESLRPVNLTQEKNILPATPIWA 567

  Fly   446 PPPKVVLHNQFHESINCSPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDVNSLPVIQCINIV 510
            |.|.:   :.....:||||...|||||.||::.:||.|::||||:::|||||:..||||....||
  Rat   568 PVPNL---SAELSKLNCSPDSFRCTLTSIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIV 629

  Fly   511 RCRLCRTYINPFVYFVDSKMWKCNLCYRVNELPDDFQFDPATKTYGDVTRRPEVRSSTIEFIAPS 575
            |||.|||||||||.|:|.:.||||||||||::|::|.::|.|::||:..:||||::||:||||.|
  Rat   630 RCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFLYNPLTRSYGEPHKRPEVQNSTVEFIASS 694

  Fly   576 EYMLRPPQPAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPGDARTQVGFICFDSFVHFYSMA 640
            :|||||||||:|||:.|||..|.::|||...|..|..:||::|||:||::||:.|||.:|||::.
  Rat   695 DYMLRPPQPAVYLFVLDVSHNAVEAGYLTVLCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQ 759

  Fly   641 EGLNQPHEMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAF 705
            |||:||..:.:.||:|.|||.||||||||.|.|||::|||..||..|.:|.:..||||.|||.||
  Rat   760 EGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFINTRETHSALGPALQAAF 824

  Fly   706 KLMQASGGRITVFQSCLPNKGPGALEPREDPNNRSA-KDVAHLNPATDFYKRFALECSGYQIACD 769
            |||..:|||::|||:.||:.|.|.|:.|||||.||: |.|.||.|||||||:.||:|||.|.|.|
  Rat   825 KLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVHHLGPATDFYKKLALDCSGQQTAVD 889

  Fly   770 LFLMNQQYSDMATISGISKHSGGCVHHFPLYQKT-KPHMVESFRSCFKRYLTRKIGFEAVMRIRC 833
            |||::.||||:|:::.:||:|.||:.::|.:..| .|...|..:...||||||||||||||||||
  Rat   890 LFLLSSQYSDLASLACMSKYSAGCIFYYPSFHSTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRC 954

  Fly   834 TRGLQVHTFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRI 898
            |:||.:|||||||||||||||||.|:|||||:.:|:|.||||.|...:|||.|||||:|:|||||
  Rat   955 TKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLADTSLVCFQTALLYTSSKGERRI 1019

  Fly   899 RVHTVCLPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAFKIAQN 963
            ||||:||||.:||.:|....|.:|.|.||:.|||||||:|:|||||||.:||.:|..:|:..|
  Rat  1020 RVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDPLSAYSSA-- 1082

  Fly   964 LPSGQSGQLIAPRSLALLPLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPEL 1028
            :.|.....|.||.||.|||||:|||||..|||.|||||||||||||..||:.||..|||.::|.|
  Rat  1083 VSSVPRSTLTAPSSLKLLPLYVLALLKQKAFRTGTSTRLDDRVYAMCQMKSQPLVHLMKMIHPNL 1147

  Fly  1029 YKIDALIYHARNSNISSNQDDDED----EDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVG 1089
            |:||.|              .||.    .|..:|:.|..:||||.|.....||||||::..|::|
  Rat  1148 YRIDRL--------------TDEGAIHVNDRVVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWIG 1198

  Fly  1090 LNVPPDVLEAVLGISSTAELGDYVYGLPNVVSNENDVLKRFILRLNYDKPYSALVQIIRDTSTAK 1154
            .....:.:|.|||......:...:..||.:.:..::..:.|:..|...:|.|.::.:::|.|.|:
  Rat  1199 KGCDSNFIENVLGYPDFGSIPQKMTHLPELDTLPSERTRSFVTWLRDSRPLSPVLHVVKDESPAR 1263

  Fly  1155 GQFTERLTDDRSESSLSYYEFLQHIRAQV 1183
            ..|.:.|.:||:|::|||||||.|::.||
  Rat  1264 TDFFQHLVEDRTEAALSYYEFLIHVQQQV 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	92/494 (19%)
		COG5028	383..1184	CDD:227361	415/817 (51%)
Sec24b	XP_038958034.1	PHA03247	<2..483	CDD:223021	93/494 (19%)
		COG5028	448..1285	CDD:227361	424/860 (49%)