Protein Alignment Sec24AB and Sec24a

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_001099250.1
• Gene: Sec24a / 287275
• RGDID: 1309451
• Length: 1089
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 491/1157 - (42%)
• Similarity: 663/1157 - (57%)
• Gaps: 155/1157 - (13%)

  Fly   108 RPPAANGPPL-TNGSNGASSANSSRTASPRPVGAAPQYAQGPIAAALNNPPLA---------SGL 162
            |.|||.|... ....|||:||:.|            .|..||:...|.:..::         .|.
  Rat     5 RIPAARGAAAGLQAQNGAASASGS------------PYTNGPVQHTLMSSQVSLSQGYDSQLPGS 57

  Fly   163 RPSPQPTHQSLANLTSNLENLNLNTTRANGGTSILPQPQTQQQYAPTVTQKDGRGVASAQTGPPQ 227
            .|.|.|.           :.||..:.::|.|.|   |...|...:|.||         :...||.
  Rat    58 YPHPMPA-----------KTLNPFSAQSNYGGS---QGSGQALNSPLVT---------SSPVPPS 99

  Fly   228 FNDANSLLAASG----VAAALVPNAMATPF-SGQKPPNLAPNPAKMFGSASMAGRPT--PAGQRI 285
            .:        ||    :|.....|..|||. ||..||...|.|...:    ....|:  |.....
  Rat   100 LH--------SGPVPRMALPTSQNPAATPMPSGSFPPGTNPAPPLNW----QYNHPSTGPQTNHF 152

  Fly   286 PYGVPPPTNPEQQ---------SQQNNNLQNAPPPPRVGAVWP---PSLPNVAAPGAQPMMPPAQ 338
            |: |..||.|...         |..:..||.:...|  |:..|   |.||....|||.|..|||.
  Rat   153 PH-VAQPTIPGNTDFTADHPYVSSGDPALQTSFKKP--GSALPLQNPPLPPTFQPGAPPGPPPAG 214

  Fly   339 QTPQTYPYSQVYQPGPQQQPPPPQSAVQPP------PPGMFGTQPTGA----------------- 380
            ..|.:        .||..|..||::|..|.      ..|:.....||:
  Rat   215 GPPPS--------RGPVPQKTPPRAAFPPSLNSAVNQEGITSNANTGSAAHSTYDEIEGGGFLAT 271

  Fly   381 ---------------------PLQYQAQAPPQAYGQHPQQAPQTAPGGPYG-TTAP-----LNVA 418
                                 |..||..|||.| |..|...  ..|.||.. |.||     |..:
  Rat   272 PQLVNQNPKTSRSVGYAYPSLPPGYQNTAPPVA-GMPPSSL--NYPSGPQAFTQAPLGANHLTAS 333

  Fly   419 QQGFS-RLWGQDTIDLMQNRHILTPATLPPPKVVLHNQFHESINCSPSIMRCTLTKIPESNSLLQ 482
            ..|.| ...|...::|:|.|::|....|.||...|.... :.:||:|.:.|||||.:|::.:||.
  Rat   334 MSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVPNLLEDV-QKLNCNPELFRCTLTSVPQTQALLN 397

  Fly   483 KSRLPLGIVIHPFRDVNSLPVIQCINIVRCRLCRTYINPFVYFVDSKMWKCNLCYRVNELPDDFQ 547
            |::||||:::|||:|:..|||:....|||||.|||||||||.|:|.:.||||||||||::|::|.
  Rat   398 KAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVNFLDQRRWKCNLCYRVNDVPEEFM 462

  Fly   548 FDPATKTYGDVTRRPEVRSSTIEFIAPSEYMLRPPQPAMYLFLFDVSIIAQQSGYLEAACAVLNR 612
            ::|.|:.||:..:||||:::||||:||||||||||||.:|||:||||..|.::|||.:.|..|..
  Rat   463 YNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLLD 527

  Fly   613 HLDEMPGDARTQVGFICFDSFVHFYSMAEGLNQPHEMTLLDIEDPFLPRPDSLLVNLKECKELVR 677
            :||.:||:.||::|||.|||.:||||:.|||:||..:.:.||:|.|:|.|::|||||.|.||||:
  Rat   528 NLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPMPENLLVNLNESKELVQ 592

  Fly   678 DLLKQLPKRFAHTHDPGSALGAALQVAFKLMQASGGRITVFQSCLPNKGPGALEPREDPNNRSAK 742
            ||||.||:.|..|.:..||||.|||.||||:..:|||::|||:.||..|.|||:|||:||.||:.
  Rat   593 DLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRSSA 657

  Fly   743 DVAHLNPATDFYKRFALECSGYQIACDLFLMNQQYSDMATISGISKHSGGCVHHFPLY-QKTKPH 806
            ...||.|:|||||:.||:|||.|.|.||||::.||||:|::..||::|.|.|:::|.| .:..|.
  Rat   658 KEIHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPV 722

  Fly   807 MVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQVHTFHGNFFVRSTDLLSLPNVNPDAGYGMQISY 871
            .|:.|:....||||||||||||||||||:||.:||||||||||||||||||||||||||.:|:|.
  Rat   723 QVQKFQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSV 787

  Fly   872 EESLTDAKTICFQAALLYTNSEGERRIRVHTVCLPVTASLPEVMHSADTEAIIGLLSKMAVDRSV 936
            ||||||.:.:.||:|||||:|:|||||||||:||||.::|.||...||.:||.|||:.|||||||
  Rat   788 EESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLANMAVDRSV 852

  Fly   937 ASNLSDARDAFINATIDVYNAFKIAQNLPSGQSGQLIAPRSLALLPLYILALLKHPAFRVGTSTR 1001
            .::|||||||.:||.||..:|::  .::.|.|...|:.|.||.|.||::|||||..:|:.||:.|
  Rat   853 TASLSDARDALVNAVIDSLSAYR--SSVLSSQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNVR 915

  Fly  1002 LDDRVYAMDCMKTLPLDQLMKYVYPELYKIDALIYHARNSNISSNQDDDEDEDEPLPELPRLQLS 1066
            ||:|::||..:|..||..||...:|.||::|.|          |::......|..:|:.|.||||
  Rat   916 LDERIFAMCQVKNQPLVHLMLTTHPSLYRVDNL----------SDEGALNINDRTIPQPPILQLS 970

  Fly  1067 AEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISSTAELGDYVYGLPNVVSNENDVLKRFI 1131
            .|.|.....||||.|:::|::||.|...:.|..|||:.:.|.:...:..||.:.:.|:..:..||
  Rat   971 VEKLSRDGAFLMDAGSVLMLWVGRNCAQNFLSQVLGVQNYASIPQTMTDLPELDTPESARMTAFI 1035

  Fly  1132 LRLNYDKPYSALVQIIRDTSTAKGQFTERLTDDRSESSLSYYEFLQHIRAQV 1183
            ..|...:|:..::.:||:.|..|..|.:.|.:||:||:|||||||.||:.||
  Rat  1036 SWLREQRPFFPILYVIREESLMKAAFLQNLVEDRTESALSYYEFLLHIQQQV 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	96/397 (24%)
		COG5028	383..1184	CDD:227361	412/809 (51%)
Sec24a	NP_001099250.1	PHA03247	<5..366	CDD:223021	104/421 (25%)
		COG5028	257..1089	CDD:227361	413/847 (49%)