Protein Alignment Sec24AB and sec24

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_594731.1
• Gene: sec24 / 2541601
• PomBaseID: SPAC22F8.08
• Length: 926
• Species: Schizosaccharomyces pombe
• Alignment Length: 940
• Identity: 300/940 - (31%)
• Similarity: 474/940 - (50%)
• Gaps: 114/940 - (12%)

  Fly   324 NVAAPGAQPMMPPAQQTPQTYPYSQVYQPGP--------------------------QQQPPPPQ 362
            |:...|.||:.|.|.|...|.||......|.                          .||||...
pombe    21 NIPPQGFQPVYPVAGQLDNTAPYVGAVAEGTAEGIVSNGEYAVGAMGAAPTNIIGSVDQQPPVSH 85

  Fly   363 S-------------------AVQPPPPGMFGTQPTGAPLQYQAQAPPQAYGQHPQQAPQTAPGGP 408
            :                   |..|.||.:              ..|.....:.|..:|.......
pombe    86 TSHKSRRQYPAEVFELTNTLAASPAPPSL--------------SEPSYVMARTPSSSPYPHDRAE 136

  Fly   409 YGTTAPLNVAQQGFSRLWGQD-----------TIDLMQNRHILTPATLPPPKVVLHNQFH----E 458
            .||.: |:....|.|  .|.|           ::||......::..|.|||.:.|...:.    .
pombe   137 VGTKS-LSAQFGGMS--LGADGAAAMPTNELVSVDLYNQTPEISDLTSPPPPINLPLSYSATGAA 198

  Fly   459 SINCSPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDV----NSLPVIQCINIVRCRLCRTYI 519
            :.||.|..:|.|:..:|.:||||:||::|..:||.|:..:    :.:||:....|.|||.||.||
pombe   199 TSNCPPKYVRSTINCVPTTNSLLKKSKIPFALVIRPYTSLVEEDDPVPVVTDTIISRCRRCRMYI 263

  Fly   520 NPFVYFVDS-KMWKCNLCYRVNELPDDFQFDPATKTYGDVTRRPEVRSSTIEFIAPSEYMLRPPQ 583
            |||..|:|: ..::||.|..|||:|..:.:|.......|..:|||:..:.::||||.|||:|.||
pombe   264 NPFSIFIDNGHRYRCNSCGIVNEVPQSYDWDSFRNVQRDRWQRPELNYAVVDFIAPQEYMVRAPQ 328

  Fly   584 PAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPG-DARTQVGFICFDSFVHFYSMAEGLNQPH 647
            |.:|:||.|:|.::..||.:..|...:...||.:|. :.|.:|.||..||.:||:|::.|..:..
pombe   329 PLVYVFLIDISFVSISSGMVGTASRAILESLDRIPNKEGRAKVAFIGVDSALHFFSVSPGAEEAT 393

  Fly   648 EMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAFKLMQASG 712
            ::.:.|:|:|||||...||:||:||::.:.:||::....||.|.|..:|||..|:.|.:|::..|
pombe   394 QLVVSDLEEPFLPRNQDLLLNLRECRQGIENLLERFQSMFATTRDSSNALGPGLKAAHRLIENIG 458

  Fly   713 GRITVFQSCLPNKGPGALEPREDP----NNRSAKDVAHLNPATDFYKRFALECSGYQIACDLFLM 773
            |:|....|.|||.|.|.||.||||    .||.:   :.|:|...|||.||:|||..|::.|:||.
pombe   459 GKICCLISSLPNVGVGKLELREDPKLLGTNRES---SLLHPNDSFYKSFAVECSTSQVSVDMFLF 520

  Fly   774 NQQYSDMATISGISKHSGGCVHHFPLYQKTKPHMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQ 838
            :.||.|:||:|.:.:::.|....:..:..::......|.|....||:.:|..|||||:|.:.||:
pombe   521 SSQYQDVATLSCLPRYTSGKTQFYHRWNASRSEDALKFASELTNYLSMEIELEAVMRVRGSNGLR 585

  Fly   839 VHTFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTV 903
            :.:|:||||.||:||.:.|:...|..|.:::..|:::| ...:.||.|:|:|...|||||||.|:
pombe   586 MSSFYGNFFNRSSDLCAFPSFPRDQSYVVEVVIEDTIT-KPFVSFQTAMLHTTCNGERRIRVLTI 649

  Fly   904 CLPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAFKIAQNLPSGQ 968
            .||.|.|:.::..|||..||...|:..|.:::::|.|::|||:.|:..:::...:|  :||....
pombe   650 SLPTTNSMTDLYASADQVAIAQYLTVRASEKALSSTLNEARDSIISKLVEILEVYK--KNLAGQN 712

  Fly   969 SGQLI---APRSLALLPLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYK 1030
            :|..|   ...:|.||||..|||.||..||..:....|.|..|:..:.|||...||:|:||.||.
pombe   713 TGAAIPLQISTNLRLLPLLCLALTKHTGFRRSSHISSDLRSIALCYLSTLPTPLLMRYIYPTLYS 777

  Fly  1031 IDALIYHARNSNISSNQDDDEDEDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPPD 1095
            :..:...|....         ::...||.  .|.|::..|.|..::|:|......:|:|.:..|.
pombe   778 LHDMPIEAGTVT---------EQGVVLPS--ALNLTSALLQSFGLYLVDTHIHQFLYIGKDAVPQ 831

  Fly  1096 VLEAVLGISSTAELGDYVYGLPNVVSNENDVLKRFIL-RL-NYDKPYSAL--VQIIRDTS--TAK 1154
            :|....|::|.|:|....:.:| |:.|..:|....|| :| :.||..:.:  :.::|...  ..:
pombe   832 LLIDAFGVNSLADLKAGRFTMP-VIDNPLNVRINAILGKLRSLDKGSTIMPSLYLVRGDGDPQLR 895

  Fly  1155 GQFTERLTDDRSESSLSYYEFLQHIRAQVK 1184
            ..|.....:||||:|.||.:|||.::.:|:
pombe   896 SWFFSHFVEDRSENSPSYLQFLQTLKEKVR 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	27/146 (18%)
		COG5028	383..1184	CDD:227361	280/834 (34%)
sec24	NP_594731.1	COG5028	1..926	CDD:227361	300/940 (32%)