Protein Alignment Sec24AB and sec-24.1

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_502178.1
• Gene: sec-24.1 / 178078
• WormBaseID: WBGene00004755
• Length: 1126
• Species: Caenorhabditis elegans
• Alignment Length: 1248
• Identity: 332/1248 - (26%)
• Similarity: 539/1248 - (43%)
• Gaps: 193/1248 - (15%)

  Fly     3 TYNPNFVPPAHAPMPLNGNNFVNGVQGSVQQQPGPPPGQQYIPQKQPQQFQQPPPAAAFPGAGAP 67
            :|.|   ||             ||      |.||.|. ||:..|.|.|....|||||....|..|
 Worm     2 SYQP---PP-------------NG------QMPGYPQ-QQFNQQPQFQSNGFPPPAAPQKPAQVP 43

  Fly    68 GNVPPP-QQFNSGITNQFLPPTSGAATPLQQ----------LPPSTLPPHLRPPAANGPPLTNGS 121
            |..||| ||.|....|..|   :|.::.|.|          ..||..||:...||  |.|   |:
 Worm    44 GGFPPPHQQPNGQYQNGGL---NGNSSHLAQSVNNMSIGARSTPSAQPPNPYQPA--GYP---GA 100

  Fly   122 NGASSANSSRTASPRPVGAAPQYAQGPIAAALNNPPLASGLRPSPQPTHQSLANLTSNLENLNLN 186
            .........|..:|:...|.||..|.| :|....|..|....|:|.|                 .
 Worm   101 PPQQLQQVQRQQTPQQFAAVPQSVQAP-SATPAGPLQAMQQAPAPTP-----------------G 147

  Fly   187 TTRANGGTSILPQPQTQQQYAPTVTQ-----KDGRGVASAQTGPPQFNDANSLLAASGVAAALVP 246
            ..:.|.|..:.|||....|..|...|     :.|...:|.|.|.|...:..........|.:..|
 Worm   148 IPQMNQGAHLPPQPHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYP 212

  Fly   247 NAMATPFSGQKPPNLAPNPAKMFGSASMAGRPT----PAGQRIPYGVPPPTNPEQQSQQNNNLQN 307
            .|...|   |.|.:..|.....|    ..|:||    |.|.::|...  |:.|.       ::..
 Worm   213 GAPQVP---QAPNSFIPPGTGGF----PPGQPTAGSFPPGPQVPGSY--PSGPA-------DIPQ 261

  Fly   308 APPPPRVGAVWPPSLPNVAAPGAQPMMPPAQ---QTPQTYPYSQVYQPGPQQQPPPPQSAVQPPP 369
            .|..||   .:||......|||.....||.|   ..|.::|..   .|||.....|...|...|.
 Worm   262 GPGMPR---AFPPGASAPVAPGMPGAFPPGQGGPGMPGSFPPG---APGPGGPGMPGSFAPGAPG 320

  Fly   370 PGMFGTQPTGAPLQYQAQAPPQAYGQHPQQAPQTAPGGPYGTTAPLNVAQQGFSRL-------WG 427
            ||..|..|:|.|      ..|...|.:        ||||         .||...||       ..
 Worm   321 PGGPGGYPSGGP------GMPGMQGGY--------PGGP---------PQQRQQRLDPNMMPSAV 362

  Fly   428 QDTIDLMQNRHILTPATLP----PPKVVLHNQFHESINCSPSIMRCTLTKIPESNSLLQKSRLPL 488
            |...|....|..:.|...|    ||.|..::...:..||:|..||.||...|::|.:|:.|::||
 Worm   363 QVIDDDSSTRSGIFPTGYPNAELPPLVSTNSFAQDQGNCNPKFMRSTLYTAPQTNDILKASQIPL 427

  Fly   489 GIVIHPFRDVNSL----PVIQC--INIVRCRLCRTYINPFVYFVD-SKMWKCNLCYRVNELPDD- 545
            .:||.||..:...    ||:..  ...:||:.|:.||.||:.|.| .:.::|..|:....:.|.
 Worm   428 AVVISPFASLTEYEKEPPVVDLGPQGPIRCQRCKAYICPFMEFQDGGRSFRCPFCHARTSVEDAY 492

  Fly   546 FQFDPATKTYGDVTRRPEVRSSTIEFIAPSEYM---LRPPQPAMYLFLFDVSIIAQQSGYLEAAC 607
            |.....|....|:..|||:.....:.:|..:|.   :.|.:|| ::|:.|||..|..:|.|...|
 Worm   493 FAHLDHTGRRTDIEMRPELCLGAYDLVATKQYCKNGIAPKEPA-FIFMIDVSYNAISNGMLPILC 556

  Fly   608 AVLNRHLDEMPG-----DARTQVGFICFDSFVHFYSMAEGLNQPHEMTLLDIEDPFLPRPDSLLV 667
            ..|.:.|..:|.     ::..::|...||..|||:.::..  .|..:.:.|:::||:|..|.||:
 Worm   557 QNLEKVLRNLPRESGQLESSMRIGLATFDQAVHFFDISSA--SPKMLVMSDVQEPFVPMVDGLLL 619

  Fly   668 NLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAFKLMQAS--GGRITVFQSCLPN-KGPGA 729
            ...|....:|..|.::||.|:.:....:.|...:|.....::.:  .|::.:|.:.||. ..||.
 Worm   620 PYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKCADRAGKVILFSTVLPTYDAPGK 684

  Fly   730 LEPREDPNNRSA----KDVAHLNPATDFYKRFALECSGYQIACDLFLMNQQYSDMATISGISKHS 790
            |:.:   |:||.    |:...|.|..|.|.:...:|....:..||||....:.|:|||..:|..:
 Worm   685 LKSK---NDRSLLGTDKEKNALVPQEDSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVT 746

  Fly   791 GGCVHHFPLYQKTKP--HMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQVHTFHGNFFVRSTDL 853
            ||.:..|..:...|.  .|:..    .:|::::||.|:.:.|:|.:.|::..||.|:|::.::..
 Worm   747 GGSIFKFQYFSADKDGVRMLNE----LERHVSKKIAFDCMARVRTSTGIRPITFTGSFYMENSTD 807

  Fly   854 LSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTVCLPVTASLPEVMHSA 918
            |.|..::....:..:|.:::||.|..:. .|.|:|||:..|:||:|:..:||||||...:|...|
 Worm   808 LELATLDESKAFITEIKHDDSLKDPASF-IQTAVLYTSMTGQRRLRILNLCLPVTADYNQVYRLA 871

  Fly   919 DTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAF--KIAQNLPSGQSGQLIAPRSLALL 981
            |.||:...:.|.||..:.....|:.|::..:........:  |.::..|   .||||.|.||.|:
 Worm   872 DPEALTAFMLKQAVQLNRDKGSSEMRESLSSRCAQFLATYREKCSEGAP---LGQLILPESLKLM 933

  Fly   982 PLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYKIDALIYHARNSNISSN 1046
            |||:.::||:.|...|:...:||:|:.|:.::.|..:.:|..:||.:..|         |::..|
 Worm   934 PLYVNSILKNDAISGGSEMTVDDKVWQMELIRGLRTENVMPLIYPRVMPI---------SDLQIN 989

  Fly  1047 QDDDEDEDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAVLGISSTAELGD 1111
             |.:|.:|.|.|    ::.|:|.|::...:::|.|.::.::||...|...::.|.|:.:|.::..
 Worm   990 -DTEEMKDLPKP----VRASSEFLENSKAYIIDNGVILFVWVGSACPQTWVQDVFGVGATNQIDT 1049

  Fly  1112 YVYGLPNVVSNENDVLKRFILRL----NYDKPYSALVQIIRDTSTAKGQFTERLTDDRS-ESSLS 1171
            ....:|...:..:..|:|.|..|    ...|.:     ::.:.|..:....:.|.:|:: .:::|
 Worm  1050 ESGTIPEKDNGHSRALRRAIQLLPRGIRERKTF-----VVVEKSGLEPWMKKFLVEDKAGPANMS 1109

  Fly  1172 YYEFLQHIRAQVK 1184
            |.::|..|..:::
 Worm  1110 YVDYLVDIHRKIR 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	96/383 (25%)
		COG5028	383..1184	CDD:227361	222/843 (26%)
sec-24.1	NP_502178.1	PRK07764	<92..279	CDD:236090	52/228 (23%)
		COG5028	381..1123	CDD:227361	208/775 (27%)